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Your Environment. Your Health.

Understanding the Combined Effects of Environmental Chemical and Non-Chemical Stressors: Atherosclerosis as a Model Workshop

April 3-4, 2018
NIEHS, Research Triangle Park, North Carolina

Meeting Sponsorship

This meeting is co-sponsored by the National Institute of Environmental Health Sciences (NIEHS) and the National Heart, Lung, and Blood Institute (NHLBI).

Meeting Purpose

A critical research area that requires further exploration is the biological mechanisms and effects of exposure to both environmental chemicals (e.g., air pollution, polycyclic aromatic hydrocarbons, metals, pesticides) and non-chemical stressors (e.g., psychosocial, lifestyle, quality of life, poor nutrition, infectious agents, physical stressors) over time and the roles they may play in the development of disease (e.g., cancer, cardiac, metabolic, neurological). The goal of this workshop is to identify key biological mechanisms/pathways of the combined effects of chemical and non-chemical stressors associated with atherosclerosis, a disease known to be initiated by both types of stressors. This workshop will bring together experts to discuss the state of the science pertaining to underlying biological pathways associated with, when combined, chemical and non-chemical stressors in relation to this disease.

The workshop will utilize the Adverse Outcome Pathway (AOP) framework to assist in the discussion of key biological mechanisms/pathways associated with this disease. For more information about the AOP framework and its use in the workshop, we ask that all registered participants watch the following webinars before participating in the workshop:

Additional Information

The NIEHS Division of Extramural Research and Training (DERT) and the NHLBI Division of Cardiovascular Sciences (DCVS) released a Request for Information (RFI) on December 5, 2016 to identify key biological mechanisms/pathways of the combined effects of chemical and non-chemical stressors associated with atherosclerosis. Information provided will be used in planning of this workshop and to help inform the development of intramural and extramural research efforts that address the combined health effects of environmental chemical and non-chemical stressors associated with atherosclerosis, a known multi-factorial disease. Input from all interested parties was welcome including the lay public, environmental health researchers, health professionals, educators, policy makers, industry, and others. The RFI closed January 31, 2017.

Meeting Location

Building 101, Rodbell Auditorium
111 TW Alexander Drive
Research Triangle Park, NC 27709


Online registration is now closed. Please contact Suzanne France ( for assistance.


Day one of this workshop, Tuesday, April 3, will be webcast. Please click here for the live broadcast.

Meeting Agenda and Breakout Group Information

A draft agenda is now available. Day 1 of the meeting will consist of oral presentations from research experts, and Day 2 will consist of breakout group discussions to address key knowledge gaps (list of Breakout Group Active Participants). The meeting will tentatively begin Tuesday, April 3 at 8:30 a.m. and end at 3:30 p.m. on the following day (Wednesday).

Hotel Accommodations

We have secured a limited block of rooms at a nearby hotel. Please go to the Accommodations page for additional information.

American Disabilities Act Accommodations Requests

Individuals with disabilities who need accommodation to participate in these events should contact Suzanne France at voice telephone: 919-794-4700 or email: TTY users should contact the Federal TTY Relay Service at 800-877-8339. Requests should be made at least 5 days in advance of the event.


For questions that can't be answered by the content of this website, please contact Danielle Carlin (, 984-287-3244). For logistical questions, please contact Suzanne France (, 919-794-4700).