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1994

Researchers Identify First Breast, Ovarian Cancer Gene: BRCA1

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two puzzle pieces connecting the word Breast Cancer to Genetics

NIEHS and collaborators at the University of Utah isolated a tumor-suppressor gene known to play a critical role in the development of hereditary breast and ovarian cancer. BRCA1 was the first breast cancer gene to be identified.


Tags: breast cancer, genes, women's health


Citation:

Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, , Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Narod S, Bristow PK, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A, Skolnick MH. 1994. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266(5182):66-71. [Abstract] [PDF]


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