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1994

Former Scientific Director Rodbell awarded Nobel Prize in Medicine

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Martin Rodbell, Ph.D.

In 1994, Martin Rodbell, Ph.D., an NIEHS scientist emeritus and former scientific director, was bestowed with the highest honor a scientist can receive, the Nobel Prize in Medicine. Pioneering studies by Rodbell and his colleagues at the NIH, laid the ground work for the discovery of “G-proteins” and their role in signal transduction, which regulates the human body's cellular “communication” activities. This discovery informed us about hormone function. It also played a role in demonstrating how light and odors are perceived, how signals travel between neurons in the brain, and how some diseases affect the function of our vital organs.


Tags: nobel, rodbell


Citation:

Birnbaumer L, Pohl SL, Rodbell M. 1971. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. II. Comparison between glucagon- and fluoride-stimulated activities. J Biol Chem 246(6):1857-1860. [Full Text]  

Cooper DM, Schlegel W, Lin MC, Rodbell M. 1979. The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP. J Biol Chem 254(18):8927-8931. [Full Text]  

Londos C, Salomon Y, Lin MC, Harwood JP, Schramm M, Wolff J, Rodbell M. 1974. 5'-Guanylylimidodiphosphate, a potent activator of adenylate cyclase systems in eukaryotic cells. I. Properties. Proc Natl Acad Sci USA 71(8):3087-3090. [Abstract]   [PDF]  

Pohl SL, Birnbaumer L, Rodbell M. 1971. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties. J Biol Chem 246(6):1849-1856. [Full Text]   

Rodbell M, Krans HM, Pohl SL, Birnbaumer L. 1971. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon. J Biol Chem 246(6):1872-1876. [Full Text]  

Rodbell M, Birnbaumer L, Pohl SL, Krans HM. 1971. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. J Biol Chem 246(6):1877-1882. [Full Text]  

Rodbell M, Krans HM, Pohl SL, Birnbaumer L. 1971. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. 3. Binding of glucagon: method of assay and specificity. J Biol Chem 246(6):1861-1871. [Full Text]  

Yamamura H, Lad PM, Rodbell M. 1977. GTP stimulates and inhibits adenylate cyclase in fat cell membranes through distinct regulatory processes. J Biol Chem 252(22):7964-7966. [Abstract]   [Full Text]  

Rodbell M. 1980. The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature 284(5751):17-22. [Abstract]


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