NTP Studies Show Hexavalent Chromium in Drinking Water Causes Cancer in Lab Animals
The National Toxicology Program announced that hexavalent chromium in drinking water causes cancer in lab animals. The announcement came at the conclusion of a two-year study in which lab animals given the chemical in drinking water developed tumors. Hexavalent chromium is used in electroplating, leather tanning, and textile manufacturing. It has also been found in drinking water sources.
Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Abdo KM, Malarkey DE, Hooth MJ. 2009. Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. Environ Health Perspect 117(5):716-722. [Article] [Full Text]
Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Walden R, Abdo K, Pritchard JB, Fernando RA, Burka LT, Hooth MJ. 2006. Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice. Toxicol Sci. 118(2):368:379.
NIEHS Programs that support the NTP:
- Cellular & Molecular Pathology Branch
- Epigenetics & Stem Cell Biology Laboratory
- Program Operations Branch
- Toxicology Branch
- 2007: Hexavalant Chromium in Drinking Water Causes Cancer in Lab Animals
Environmental Health Perspectives articles: