More Than 8 Million Genetic Variations, or Single Nucleotide Polymorphisms (SNPs), Identified in 15 Mouse Strains
Researchers announce they have successfully sequenced the DNA of 15 mouse strains most commonly used in biomedical research. More than 8.3 million genetic variations, or single nucleotide polymorphisms (SNPs), were discovered among the genomes of the 15 mouse strains, and the data are now available on a public website.
Tags: genes, polymorphisms
Frazer KA, Eskin E., Kang HM, Bogue MA, Hinds DA, Beilharz EJ, Gupta RV, Montgomery J, Morenzoni MM, Nilsen GB, Pethiyagoda CL, Stuve LL, Johnson FM, Daly MJ, Wade CM, Cox DR. 2007. A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448(7157):1050-1053.
NIEHS Funded Research:
- 2007: Mouse Genome Will Help Identify Causes of Environmental Disease
- 2006: Mouse DNA to Aid Biomedical Research
- 2006: Two NIH Initiatives Launch Intensive Efforts to Determine Genetic and Environmental Roots of Common Diseases
Environmental Health Perspectives article: