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Estrogen Receptor Beta Assists in Fertility

male sperm traveling toward female egg

New research suggests that medications commonly referred to as fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta. The study showed that fertility drugs did not improve ovulation rates in mice that were genetically engineered to lack estrogen receptor beta. The estrogen receptor beta is one of two estrogen receptor proteins which mediate the effects of estrogen hormones and are present throughout the female reproductive tissues. These new data indicate that this receptor plays a critical role in ovulation, and suggests that women who do not have this receptor may benefit more from alternative infertility treatments.

Tags: women's health


Couse JF, Yates MM, Deroo BJ, Korach KS. Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins. Endocrinology. 2005 Aug;146(8):3247-62. [Abstract]

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  • New Discovery May Help Doctors Treat Infertility

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