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Toll-like Receptor 4 (TLR4) Important in Immune Function

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NIEHS researchers discovered a gene that plays an important role in immune function, known as toll-like receptor 4 (TLR4). It may also play a critical role in suppressing chronic lung inflammation and tumor development in mice.

Tags: genes, inflammation, lung


Bauer AK, Dixon D, DeGraff LM, Cho HY, Walker CR, Malkinson AM, Kleeberger SR. 2005. Toll-Like Receptor 4 in Butylated Hydroxytoluene-Induced Mouse Pulmonary Inflammation and Tumorigenesis. J Natl Cancer Inst 97(23):1778-1781. [Abstract] [Full Text]

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News Release:

  • 2005: TLR4 Gene Found to Protect against Tumor Development

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