Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.


Back to List


Toll-like Receptor 4 (TLR4) Important in Immune Function

hand blocking germs and viruses

NIEHS researchers discovered a gene that plays an important role in immune function, known as toll-like receptor 4 (TLR4). It may also play a critical role in suppressing chronic lung inflammation and tumor development in mice.

Tags: genes, inflammation, lung


Bauer AK, Dixon D, DeGraff LM, Cho HY, Walker CR, Malkinson AM, Kleeberger SR. 2005. Toll-Like Receptor 4 in Butylated Hydroxytoluene-Induced Mouse Pulmonary Inflammation and Tumorigenesis. J Natl Cancer Inst 97(23):1778-1781. [Abstract] [Full Text]

More Information:

NIEHS Research Funding:

News Release:

  • 2005: TLR4 Gene Found to Protect against Tumor Development

to Top