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Glucocorticoids and Tumor Necrosis Factor Alpha Play Unique Role in Regulating Inflammation

inflammation inside human body

Researchers identified a unique cooperative role for certain hormones and proteins in the body, specifically glucocorticoids and tumor necrosis factor alpha, in regulating adaptive immunity and inflammation. Inflammation has been implicated as a contributing factor in several human cancers, including lung cancer. These results have important implications for immune responses to agents like bacterial lipopolysaccharides and numerous other environmental agents.

Tags: cancer, immune, inflammation, lung


Hermoso MA, Matsuguchi T, Smoak K, Cidlowski JA. 2004. Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression. Mol Cell Biol. 24(11):4743-4756.

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