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2004

Protein May Block Progression of Alzheimer's Disease

elderly woman

NIEHS-funded researchers identified a brain protein known as transthyretin that may block the progression of Alzheimer's disease by inhibiting the effects of another protein, beta-amyloid peptide.

Tags: DNA, genes, polymorphisms

Citation:

Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA. 2004. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: Support for the amyloid hypothesis. J Neurosci. 24(35):7707-7717. [Abstract] [Full Text]

More Information:

NIEHS Research Funding:

News Releases:

  • 2010: Targeting the Blood-Brain Barrier May Delay Progression of Alzheimer’s Disease
  • 2001: Environmental Health Institute Scientists Begin to Unravel Cause of Blocked Memory in Alzheimer's

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