Cadmium Inactivates Cell Repair System
A heavy metal environmental toxicant, cadmium, can inactivate an important cellular repair system, NIEHS researchers showed. Cadmium was found to cause mutations in DNA by inhibiting DNA mismatch repair. This mismatch repair system is important for keeping mutations from occurring during DNA synthesis.
Jin YH, Clark AB, Slebos RJ, Al-Refai H, Taylor JA, Kunkel TA, Resnick MA, Gordenin DA. 2003. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet 34(3):326-329. Abstract [Full Text]
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