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Two New Lines of Genetically Altered Mice Developed to Study Cancer

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NIEHS researchers produced two lines of genetically altered mice that have a significant impact on the study of cancer development. Research with these mice showed that removal of two genes, COX-1 and COX-2, lead to a significant decrease in development of colon, skin, and intestinal cancers in laboratory animals.

Tags: cancer, genes


Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, Dunson DB, Rogan EG, Morham SG, Smart RC, Langenbach R. 2002. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 62(12):3395-3401. [Abstract] [Full Text]

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