Two New Lines of Genetically Altered Mice Developed to Study Cancer
NIEHS researchers produced two lines of genetically altered mice that have a significant impact on the study of cancer development. Research with these mice showed that removal of two genes, COX-1 and COX-2, lead to a significant decrease in development of colon, skin, and intestinal cancers in laboratory animals.
Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, Dunson DB, Rogan EG, Morham SG, Smart RC, Langenbach R. 2002. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 62(12):3395-3401. [Abstract] [Full Text]
- National Toxicology Program (NTP)
- NTP Interagency Center for the Evaluation of Alternative Toxicological Methods
- 2007: Mouse Genome Will Help Identify Causes of Environmental Disease