Researchers identify first breast, ovarian cancer gene: BRCA1
NIEHS and collaborators at the University of Utah isolated a tumor-suppressor gene known to play a critical role in the development of hereditary breast and ovarian cancer. BRCA1 was the first breast cancer gene to be identified.
Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, , Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Narod S, Bristow PK, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A, Skolnick MH. 1994. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266(5182):66-71. [Abstract] [PDF]
NIEHS Research Funding:
Environmental Health Perspectives articles:
- Fifty Thousand Strong: The Sister Study, with Dale Sandler
- Community-Initiated Breast Cancer and Environment Studies and the Precautionary Principle