Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC. Get the latest research information from NIH.

Your Environment. Your Health.

Details

Back to List

2010

Federal agencies collaborate in Tox21 to reduce animal testing

Robotic arm

Testing the safety of chemicals is becoming more efficient and less reliant on animals thanks to a federal collaboration known as Tox 21. Tox 21 brings together scientists from the National Institutes of Health (NIH), NIEHS, the National Toxicology Program (NTP), the Environmental Protection Agency (EPA), and most recently the Food and Drug Administration (FDA) to test the safety of chemicals using state-of-the-art robotic technology that will reduce the reliance on animal testing.

The goal of this partnership is to test at the NIH Chemical Genomics Center (NCGC) approximately 10,000 compounds of toxicological concern using quantitative high-throughput screening assays that provide information on the ability of these compounds to affect key cellular pathways associated with the induction and/or progression of human disease.

The agencies signed a five-year memorandum of understanding that builds on the experimental toxicology expertise at the National Toxicology Program headquartered at NIEHS; the high-throughput technology at the NCGC; and the computational toxicology capabilities at the EPA National Center for Computational Toxicology. The agreement provides for sample and information sharing necessary to more rapidly and effectively identify chemicals that might pose risks to the health of humans and animals or to the environment. It identifies opportunities for coordination in four basic areas related to testing goals: identification of toxicity pathways, selection of chemicals for testing, analysis and interpretation of data, and outreach to scientific and regulatory communities.


Tags: National Toxicology Program, Report on Carcinogens, notable NIEHS program, toxicity


Citation:


Back
to Top