Agency Guidelines/Regulations

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1 77 FR 52333 - International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward 08-29-2012 2012-21368 PDF
2 77 FR 61610 - ICCVAM Evaluation Report and Recommendations for Identifying Chemical Eye Hazards With Fewer Animals; Availability of Report; Notice of Transmittal to Federal Agencies 10-10-2012 2012-24868 PDF
3 OECD Series on Testing and Assessment No. 203: New Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Skin Corrosion and Irritation 07-11-2014 OECD GD 203 PDF
4 OECD Guidance Document 211: Guidance Document for Describing Non-Guideline In Vitro Test Methods 12-15-2014 OECD GD 211 PDF
5 OECD Test Guideline 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method 09-26-2014 OECD TG 431 PDF
6 OECD Test Guideline 442C: In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay 02-04-2015 OECD TG 442C PDF
7 OECD Test Guideline 442D: In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method 02-04-2015 OECD TG 442D PDF
8 OECD Test Guideline 456: H295R Steroidogenesis Assay 07-28-2011 OECD TG456 PDF
9 OECD Test Guideline 473: In Vitro Mammalian Chromosomal Aberration Test 09-26-2014 OECD TG 473 PDF
10 OECD Test Guideline 487: In Vitro Mammalian Cell Micronucleus Test 09-28-2014 OECD TG 487 PDF
11 OECD Test Guideline 489: In Vivo Mammalian Alkaline Comet Assay 09-26-2014 OECD TG 489 PDF
12 Use of Humane Endpoints and Methods in Animal Testing of Biological Products 05-25-2012 USDA CVB 12-12 PDF
13 Changes to the Rabies Virus NIH Potency Test Validity Requirements 07-26-2013 USDA CVB 13-10 PDF
14 Exemption from Leptospira Bacterin Testing Under 9 CFR 113.101-104 and the Associated References and Studies 12-12-2013 VS 800.102 PDF
15 Guidelines for Validation of In Vitro Potency Assays 04-10-2015 VS 800.112 PDF
16 Alternative Test Procedure for Tuberculin, PPD Bovis, Intradermic 04-13-2012 VS 800.114 PDF
17 Animal Safety Testing Exemption 07-31-2013 VS 800.116 PDF
18 79 FR 35176 - NICEATM Requests Data and Information on Devices and/or Technologies Used for Identifying Potential Inhalation Hazards 06-19-2014 2014-14300 PDF
19 79 FR 36079 - Adverse Outcome Pathways: From Research to Regulation Workshop; Notice of Public Meeting and Registration Information 06-25-2014 2014-14738 PDF
20 79 FR 40764 - SACATM: Announcement of Meeting; Request for Comments 07-14-2014 2014-16452 PDF
21 79 FR 73603 - ICCVAM Communities of Practice Webinar on Reverse Toxicokinetics; Notice of Public Webinar and Registration Information 12-11-2014 2014-29018 PDF
22 79 FR 20217 - Collaborative Workshop on Aquatic Models and 21st Century Toxicology 04-11-2014 2014-08082 PDF
23 79 FR 25136 - ICCVAM Notice of Public Meeting; Request for Public Input 05-02-2014 2014-10015 PDF
24 79 FR 27323 - NICEATM Requests the Nomination of Reference Chemicals 05-13-2014 2014-10892 PDF
25 80 FR 47501 - Workshop on Alternative Approaches for Identifying Acute Systemic Toxicity: Moving From Research to Regulatory Testing 08-07-2015 2015-19379 PDF
26 80 FR 20001 - ICCVAM Notice of Public Meeting; Request for Public Input 04-14-2015 2015-08528 PDF
27 OECD Test Guideline 223: Avian Acute Oral Toxicity Test 07-22-2010 OECD TG 223 PDF
28 OECD Guidance Document 33: Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures 08-14-2001 OECD GD 33 PDF
29 77 FR 73289 - Hazardous Substances and Articles; Administration and Enforcement Regulations: Revisions to Animal Testing Regulations 12-10-2012 2012-29258 PDF
30 77 FR 73286 - Codification of Animal Testing Policy 12-10-2012 2012-29260 PDF
31 16 CFR 1500.3: CPSC - Hazardous Substances - Definitions 01-01-2010 16 CFR 1500.3 PDF
32 16 CFR 1500.4: CPSC - Human Experience with Hazardous Substances 01-01-2000 16 CFR 1500.4 PDF
33 16 CFR 1500.41: CPSC - Method of Testing Primary Irritant Substances 01-01-2000 16 CFR 1500.41 PDF
34 16 CFR 1500.42: CPSC - Test for Eye Irritants 01-01-2000 16 CFR 1500.42 PDF
35 49 CFR 173.132: DOT Class 6 - Definitions 10-01-1998 49 CFR 173.132 PDF
36 49 CFR 172.442: DOT - Corrosive Label (appearance and placement) 10-01-2000 49 CFR 172.442 PDF
37 49 CFR 172.558: DOT - Corrosive Placard (appearance) 10-01-2000 49 CFR 172.558 PDF
38 DOT Research and Special Programs Administration: Shippers - General Requirements for Shipments and Packaging 10-01-1998 DOT 49.173 PDF
39 49 CFR 173.133: DOT Assignment of packing group and hazard zones for Division 6.1 materials 10-01-1999 49 CFR 173.133 PDF
40 49 CFR 173.136: DOT Class 8 Definitions 10-01-2000 49 CFR 173.136 PDF
41 49 CFR 173.137: DOT Class 8 - Assignment of Packing Group 10-01-2000 49 CFR 173.137 PDF
42 DOT Pipeline and Hazardous Materials Safety Administration: Special permit authorizing the use of alternative test method for corrosivity testing 05-03-2006 DOT-SP 10904 PDF
43 EPA Health Effects Test Guidelines: Acute Dermal Toxicity 06-01-1996 OPPTS 870.1200 PDF
44 EPA Health Effects Test Guidelines: Acute Inhalation Toxicity 08-01-1998 OPPTS 870.1300 PDF
45 EPA Health Effects Test Guidelines: 21/28-Day Dermal Toxicity 08-01-1998 OPPTS 870.3200 PDF
46 EPA Health Effects Text Guidelines: Dermal Penetration 08-01-1998 OPPTS 870.7600 PDF
47 EPA Health Effects Test Guidelines: Dermal Penetration 08-01-1998 NA PDF
48 EPA Health Effects Test Guidelines: Estrogen Receptor Transcriptional Activation (Human Cell Line (HeLa- 9903)) 10-01-2009 OPPTS 890.1300 PDF
49 EPA Office of Pesticide Programs: Guidance for Waiving or Bridging of Mammalian Acute Toxicity Tests 03-01-2012 NA PDF
50 EPA Guidelines for Developmental Toxicity Risk Assessment 12-05-1991 EPA 56FR63798 PDF
51 EPA Office of Pesticide Programs: Use of an Alternate Testing Framework for Classification of Eye Irritation Potential of EPA Pesticide Products 05-31-2013 NA PDF
52 EPA Update on the Use of the Local Lymph Node Assay for End Use Pesticide Products and Adoption of the Reduced Dose Protocol for LLNA 04-01-2011 NA PDF
53 Environmental Protection Agency: Revised Final Health Effects Test Guideline; Skin Sensitization; Notice of Availability 03-25-2003 EPA FR 03-7057 PDF
54 EPA Method 1120 - Dermal Corrosion 12-01-1996 EPA 1120 PDF
55 40 CFR 152: EPA Pesticide Registration and Classification Procedures 07-01-1999 40 CFR 152 PDF
56 40 CFR 152.170 EPA Criteria for Restriction to use by Certified Applicators 07-01-2000 40 CFR 152.170 PDF
57 40 CFR 156: EPA Labeling Requirements for Pesticides and Devices 07-01-1999 40 CFR 156 PDF
58 40 CFR 157.22: EPA - Child-Resistant Packaging; When Required 07-01-2000 40 CFR 157.22 PDF
59 40 CFR 158.70: EPA Acceptable Protocols 07-01-2000 EPA 40.158.70 PDF
60 EPA Health Effects Test Guidelines: Acute Eye Irritation 08-01-1998 OPPTS 870.2400 PDF
61 EPA Health Effects Test Guidelines; Acute Dermal Irritation 08-01-1998 OPPTS 870.2500 PDF
62 EPA Health Effects Test Guidelines: Repeated Dose 28-Day Oral Toxicity Study in Rodents 07-01-2000 OPPTS 870.3050 PDF
63 EPA Health Effects Test Guidelines: Reproduction/Developmental Toxicity Screening Test 07-01-2000 OPPTS 870.3550 PDF
64 EPA Health Effects Test Guideline: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test 07-01-2000 OPPTS 870.3650 PDF
65 EPA Health Effects Test Guidelines: Prenatal Developmental Toxicity Study 08-01-1998 OPPTS 870.3700 PDF
66 EPA Health Effects Test Guidelines: Reproduction and Fertility Effects 08-01-1998 OPPTS 870.3800 PDF
67 EPA Health Effects Test Guidelines: Acute Toxicity Testing - Background 12-01-2002 OPPTS 870.1000 PDF
68 EPA Health Effect Test Guidelines: Acute Oral Toxicity 12-01-2002 OPPTS 870.1100 PDF
69 EPA Health Effects Test Guidelines: Skin Sensitization 03-01-2003 OPPTS 870.2600 PDF
70 EPA Method 9040B - pH Electrometric Measurement 01-01-1995 EPA 9040B PDF
71 EPA Report of the FIFRA Scientific Advisory Panel Meeting (Dec. 2001) 02-25-2002 NA PDF
72 40 CFR 160: EPA Good Laboratory Practice Standards 07-01-1997 40 CFR 160 PDF
73 Environmental Protection Agency: Food Quality Protection Act of 1996 08-03-1996 PL 104-170 PDF
74 Environmental Protection Agency: Safe Drinking Water Act Amendments of 1996 08-06-1996 PL 104-182 PDF
75 European Pharmacopoeia: Newcastle Disease Vaccine (Inactivated) 01-01-2008 NA PDF
76 European Pharmacopoeia: Botulinum Toxin Type A for Injection 01-01-2005 NA PDF
77 European Pharmacopoeia: Botulinum Antitoxin 01-01-2005 NA PDF
78 FDA Guidance: Photosafety Testing 05-01-2003 3640 PDF
79 21 CFR 58: FDA Good Laboratory Practice for Nonclinical Laboratory Studies 04-01-2002 21 CFR 58 PDF
80 21 CFR 211.167: FDA Good Manufacturing Practice for Finished Pharmaceuticals: Special Testing Requirements 04-01-2005 21 CFR 211.167 PDF
81 21 CFR 610.13: FDA General Biological Products Standards: Purity 04-01-2005 21 CFR 610.13 PDF
82 21 CFR 610.9: FDA General Provisions: Equivalent methods and processes 04-01-2005 21 CFR 610.9 PDF
83 21 CFR 600.3: FDA Definitions 04-01-2005 21 CFR 600.3 PDF
84 21 CFR 610.10: FDA Potency 04-01-2005 21 CFR 610.10 PDF
85 FDA Guidance: Instructions and Template for Chemistry, Manufacturing, and Control (CMC) Reviewers of Human Somatic Cell Therapy Investigational New Drug Applications (INDs) 08-01-2003 NA PDF
86 FDA Guidance: Content and Review of Chemistry, Manufacturing, and Control (CMC) Information for Human Gene Therapy Investigational New Drug Applications (INDs) 11-01-2004 NA PDF
87 FDA Guidance: Considerations for Plasmid DNA Vaccines for Infectious Disease Indications 02-01-2005 NA PDF
88 FDA Guidance: Preparation of a Premarket Notification Application for a Surgical Mesh 03-01-1999 NA PDF
89 74 FR 33444 - Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and Approaches: Notice of Availability and Request for Public Comments 07-13-2009 E9-16388 PDF
90 74 FR 14556 - Announcement of an Independent Scientific Peer Review Panel on Alternative Ocular Safety Testing Methods; Availability of Draft Background Review Documents (BRD); Request for Comments 03-31-2009 E9-7220 PDF
91 66 FR 36294 - Peer Review Panel for the Up-and-Down Procedure (UDP): Notice of Meeting 07-11-2001 01-17288 PDF
92 75 FR 25866 - Federal Agency Responses to ICCVAM Recommendations on the Murine Local Lymph Node Assay, An Alternative Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products: Notice of Availability 05-10-2010 2010-10954 PDF
93 75 FR 25867 - International Workshop on Alternative Methods To Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the Science and Future Directions 05-10-2010 2010-10958 PDF
94 75 FR 26757 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 05-12-2010 2010-11318 PDF
95 75 FR 32942 - Availability of the ICCVAM Biennial Progress Report 06-10-2010 2010-13952 PDF
96 75 FR 37443 - Availability of ICCVAM Test Method Evaluation Reports on Two Nonradioactive Versions of the Murine Local Lymph Node Assay for Assessing Allergic Contact Dermatitis Hazard Potential of Chemicals and Products, and Expanded Uses of the Local Lymph Node Assay for Pesticide Formulations and Other Products; Notice of Transmittal to Federal Agencies 06-29-2010 2010-15777 PDF
97 75 FR 57027 - Availability of Test Method Evaluation Reports: In Vitro Ocular Safety Testing Methods and Strategies, and Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints for Ocular Safety Testing; Notice of Transmittal to Federal Agencies 09-17-2010 2010-23262 PDF
98 75 FR 62845 - Workshop Series on Best Practices for Regulatory Safety Testing: Assessing the Potential for Chemically Induced Eye Injuries and Chemically Induced Allergic Contact Dermatitis (ACD) 10-13-2010 2010-25676 PDF
99 76 FR 23323 - Meeting of SACATM 04-26-2011 2011-10020 PDF
100 76 FR 28781 - Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of an In Vitro Estrogen Receptor Transcriptional Activation Test Method for Endocrine Disruptor Chemical Screening: Notice of Availability and Request for Public Comments 05-18-2011 2011-12264 PDF
101 76 FR 29752 - Nomination of In Vitro Test Methods for Detection and Quantification of Botulinum Neurotoxins and Detection of Non-Endotoxin Pyrogens; Data Request for Substances Evaluated by These Test Methods 05-23-2011 2011-12627 PDF
102 76 FR 4113 - Announcement of an Independent Scientific Peer Review Panel Meeting on an In Vitro Estrogen Receptor Transcriptional Activation Test Method for Endocrine Disruptor Chemical Screening; Availability of Draft Background Review Document (BRD); Request for Comments 01-24-2011 2011-1329 PDF
103 76 FR 45254 - Report and Recommendations on the Usefulness and Limitations of the Murine Local Lymph Node Assay for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans 07-28-2011 2011-18639 PDF
104 76 FR 50220 - Availability of Draft ICCVAM Recommendations on Using Fewer Animals to Identify Chemical Eye Hazards: Revised Criteria Necessary to Maintain Equivalent Hazard Classification; Request for Comments 08-12-2011 2011-20537 PDF
105 76 FR 50221 - International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward 08-12-2011 2011-20540 PDF
106 76 FR 71977 - Update of the NICEATM-ICCVAM Five-Year Plan: Request for Comments 11-21-2011 2011-30001 PDF
107 76 FR 2388 - Federal Agency Responses to ICCVAM Recommendations on Two Nonradioactive Versions of the LLNA for Assessing ACD Hazard Potential of Chemicals and Products, and Expanded Uses of the LLNA for Pesticide Formulations and Other Products; Notice of Availability 01-13-2011 2011-669 PDF
108 76 FR 20672 - Recommendations on In Vitro Ocular Safety Testing Methods and Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints for Ocular Safety Testing 04-13-2011 2011-8398 PDF
109 77 FR 35395 - Draft Five-Year Plan (2013-2017) for NICEATM and ICCVAM 06-13-2012 2012-14435 PDF
110 77 FR 35393 - Availability of ICCVAM Biennial Progress Report 06-13-2012 2012-14436 PDF
111 77 FR 40358 - Meeting of SACATM 07-09-2012 2012-16675 PDF
112 77 FR 41406 - Evaluation of In Vitro Tests for Identifying Eye Injury Hazard Potential of Chemicals and Products: Request for Nominations for an Independent Expert Panel and Submission of Relevant Data 07-13-2012 2012-17118 PDF
113 77 FR 43089 - Evaluation of an Up-and-Down Procedure for Acute Dermal Systemic Toxicity Testing: Request for Nominations for an Independent Expert Panel and Submission of Relevant Data 07-23-2012 2012-17787 PDF
114 77 FR 43087 - Nomination of an In Vitro Test Method for the Identification of Contact Allergens: Request for Comments and Data 07-23-2012 2012-17788 PDF
115 77 FR 43827 - International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward 07-26-2012 2012-18294 PDF
116 77 FR 50510 - Federal Agency Responses to ICCVAM Recommendations on the Usefulness and Limitations of the LUMI-CELL (reg) ER (BG1Luc ER TA) Test Method, an In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals 08-21-2012 2012-20549 PDF
117 77 FR 8258 - Availability of ICCVAM Evaluation Report and Recommendations on the Usefulness and Limitations of the LUMI-CELL (reg) ER (BG1Luc ER TA) Test Method, An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals 02-14-2012 2012-3437 PDF
118 77 FR 11536 - ICCVAM Recommendations on Use of LLNA for Potency Categorization of Chemicals Causing ACD: Availability of Federal Agency Responses 02-27-2012 2012-4541 PDF
119 77 FR 2064 - Availability of the Report on the International Workshop on Alternative Methods To Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the Science and Future Directions 01-13-2012 2012-563 PDF
120 77 FR 22321 - NICEATM Call for Nominations of High Throughput Screening (HTS) Assays for the Tox21 Initiative 04-13-2012 2012-8942 PDF
121 78 FR 45253 - SACATM: Announcement of Meeting; Request for Comments 07-26-2013 2013-17919 PDF
122 78 FR 68076 - Request for Information on Alternative Skin Sensitization Test Methods and Testing Strategies and for Comment on ICCVAM's Proposed Activities 11-13-2013 2013-27095 PDF
123 62 FR 55649 - Notice of Meeting to Discuss the Procedures and Activities of the National Toxicology Program (NTP) Center for the Evaluation of Alternative Toxicological Methods and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 10-24-1997 97-28373 PDF
124 73 FR 25754 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 05-07-2008 E8-10010 PDF
125 73 FR 29136 - Peer Review Panel Report on the Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay (LLNA): A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products: Notice of Availability and Request for Public Comments 05-20-2008 E8-11195 PDF
126 73 FR 63150 - Availability of the Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): NIH Publication No. 086529 10-23-2008 E8-25223 PDF
127 73 FR 71003 - Availability of the ICCVAM Test Method Evaluation Report and Final Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products; Notice of Transmittal of ICCVAM Test Method Recommendations to Federal Agencies 11-24-2008 E8-27790 PDF
128 73 FR 18535 - Non-Animal Methods and Approach for Evaluating Eye Irritation Potential for Antimicrobial Cleaning Products (AMCPs): Request for Nominations for an Independent Expert Panel and Submission of Relevant Data 04-04-2008 E8-6969 PDF
129 74 FR 26242 - Independent Scientific Peer Review Panel Report: Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products: Notice of Availability and Request for Public Comments 06-01-2009 E9-12360 PDF
130 74 FR 29214 - Meeting of SACATM: Amended Notice 06-19-2009 E9-14502 PDF
131 74 FR 50212 - Availability of the ICCVAM Test Method Evaluation Report on the Reduced Murine Local Lymph Node Assay (rLLNA); Availability of ICCVAM Recommended Murine Local Lymph Node Assay (LLNA) Performance Standards; Notice of Transmittal to Federal Agencies of ICCVAM Recommendations for the rLLNA, Updated LLNA Test Method Protocol, and LLNA Test Method Performance Standards 09-30-2009 E9-23534 PDF
132 74 FR 62317 - Evaluation of In Vitro Estrogen Receptor Transcriptional Activation and In Vitro Cell Proliferation Assays for Endocrine Disruptor Chemical Screening: Request for Nominations for an Independent Expert Peer Review Panel and Submission of Relevant In Vitro and In Vivo Data 11-27-2009 E9-28278 PDF
133 74 FR 8974 - Announcement of a Second Meeting of the Independent Scientific Peer Review Panel on the Murine Local Lymph Node Assay; Availability of Draft Background Review Documents (BRD); Request for Comments 02-27-2009 E9-4280 PDF
134 74 FR 19562 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 04-29-2009 E9-9845 PDF
135 65 FR 35109 - Notice of Peer Review Meeting on the Revised Up-and-Down Procedure (UDP) as an Alternative Test Method for Assessing Acute Oral Toxicity; Request for Comments 05-31-2000 00-13734 PDF
136 65 FR 37400 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Request for Data and Suggested Expert Scientists 06-13-2000 00-14968 PDF
137 65 FR 57203 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Workshop Agenda and Registration Information 09-20-2000 00-24244 PDF
138 65 FR 66549 - Meeting of the Advisory Committee on Alternative Toxicological Methods 11-03-2000 00-28342 PDF
139 65 FR 7878 - Meeting of the Advisory Committee on Alternative Toxicological Methods 02-15-2000 00-3590 PDF
140 65 FR 8385 - Request for Data and Nomination of Expert Scientists To Participate in the Independent Peer Review Evaluation of the Revised Up-and-Down Procedure for Assessing Acute Oral Toxicity; Evaluation of the Up-and-Down Procedure 02-17-2000 00-4010 PDF
141 65 FR 13289 - Notice of Expert Panel Meeting on the Frog Embryo Teratogenesis -- Xenopus 03-10-2000 00-6013 PDF
142 66 FR 33550 - The Revised Draft Up-and-Down Procedure for Assessing Acute Oral Toxicity: Notice of Availability and Requests for Public Comments 06-21-2001 01-15770 PDF
143 66 FR 46020 - Meeting of the Advisory Committee on Alternative Toxicological Methods 08-30-2001 01-21987 PDF
144 66 FR 49196 - Amended Notice of Meeting 09-25-2001 01-24034 PDF
145 66 FR 49686 - Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity; Notice of Availability and Request for Public Comment 09-27-2001 01-24370 PDF
146 66 FR 49685 - EPISKIN(TM), EPIDERM(TM), and Rat Skin Transcutaneous Electrical Resistance Methods: In Vitro Test methods Proposed for Assessing the Dermal Corrosivity Potential of Chemicals; Notice of Availability of a Background Review Document and Proposed ICCVAM Test Method Recommendations and Request for Public Comment 09-27-2001 01-24371 PDF
147 66 FR 16278 - Request for Data and Nominations of Expert Scientists for an Independent Peer Review Evaluation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays for Endocrint Disruptor Screening 03-22-2001 01-7228 PDF
148 67 FR 49706 - Availability of the Report, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of EPISKIN(TM), EPIDERM(TM) (EPI-200), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals 07-30-2002 02-19261 PDF
149 67 FR 64902 - Notice of Availability of an Expert Panel Report on the Current Validation Status of In Vitro Endocrine Disruptor Screening Methods and a Proposed List of Substances for Validation of In Vitro Endocrine Disruptor Screening Methods; Request for Comments 10-21-2002 02-26733 PDF
150 67 FR 67203 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 11-01-2002 02-27902 PDF
151 67 FR 5842 - Report on the Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals; Notice of Availability and Request for Public Comments 02-06-2002 02-2905 PDF
152 67 FR 5845 - Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Notice of Availability 02-06-2002 02-2907 PDF
153 67 FR 77064 - Environmental Protection Agency: Revised Final Health Effects Test Guidelines; Acute Toxicity Testing - Background and Acute Oral Toxicity; Notice of Availability 12-12-2002 02-31612 PDF
154 67 FR 11358 - Notice of Establishment; Scientific Advisory Committee on Alternative Toxicological Methods 03-12-2002 02-5932 PDF
155 67 FR 16415 - Notice of an Expert Panel Meeting to Assess the Current Validation Status of In Vitro Endocrine Disruptor Screening Methods; Request for Comments 04-04-2002 02-8328 PDF
156 68 FR 33171 - Notice of Availability of the Report: "Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays" 06-02-2003 03-13839 PDF
157 68 FR 39104 - Notice of Availability of Proposed Minimum Performance Standards (MPS) for Three Types of In Vitro Methods for Assessing the Dermal Corrosivity Hazard Potential of Chemicals; Request for Comments 06-30-2003 03-16506 PDF
158 68 FR 42067 - Request for Existing Dermal and Ocular Irritancy Chemical Test Data from Animal and Human Studies Using Standardized Testing Methods 07-15-2003 03-18011 PDF
159 68 FR 42066 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 07-15-2003 03-18012 PDF
160 68 FR 64636 - Request for Nominations and Submissions fo Alternative Test Methods for Evaluation by ICCVAM; Notice of the Availability of the Updated Document, "ICCVAM Guidelines for Nomination and Submission of New, Revised, and Alternative Test Methods" 11-13-2003 03-28560 PDF
161 69 FR 30693 - Notice of Availability of Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion 05-27-2004 04-12126 PDF
162 69 FR 54298 - Notice of Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 09-07-2004 04-20292 PDF
163 69 FR 61504 - Availability of Updated Standardized In Vitro Cytotoxicity Test Method Protocols for Estimating Acute Oral Systemic Toxicity; Request for Existing In Vivo and In Vitro Acute Toxicity Data 10-18-2004 04-23335 PDF
164 69 FR 64081 - Notice of an Expert Panel Meeting to Assess the Current validation Status of In Vitro Testing Methods for Identifying Potential Ocular Irritants; Request for Comments 11-02-2004 04-24481 PDF
165 69 FR 70268 - Notice of Additional Data and Analyses for the Assessment of the Current Validation Status of In Vitro Testing Methods for Identifying Potential Ocular Irritants 12-02-2004 04-26594 PDF
166 69 FR 6674 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 02-10-2004 04-2931 PDF
167 69 FR 7777 - Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Notice of Availability 02-18-2004 04-3528 PDF
168 69 FR 11448 - Notice of Availability of Agency Responses to ICCVAM Test Recommendations for the Revised Up-and-Down Procedure for Determining Acute Oral Toxicity and In Vitro Methods for Assessing Acute Systemic Toxicity 03-09-2004 04-5321 PDF
169 69 FR 13859 - Request for Public Comment on the Nomination for Ocular Toxicity Test Methods and Related Activities and Request for Data on Chemicals Evaluated by In Vitro or In Vivo Ocular Irritancy Test Methods 03-23-2004 04-6487 PDF
170 69 FR 21564 - In Vitro Endocrine Disruptor Test Methods: Request for Comments and Nominations 04-20-2004 04-8980 PDF
171 69 FR 21565 - Request for Nominations of Scientific Experts for Independent Expert Panel Evaluations and/or Other Reviews of In Vitro Testing Methods for Identifying Potential Ocular Irritants 04-20-2004 04-9032 PDF
172 70 FR 35687 - National Institute of Environmental Health Sciences 2006 Strategic Plan; Request for Comments and Nominations 06-20-2005 05-12129 PDF
173 70 FR 43149 - Availability of Revised Analyses and Proposed Reference Substances for In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 07-25-2005 05-14707 PDF
174 70 FR 53676 - Announcement of Expert Panel Meeting to Evaluate Revised Analyses and Proposed Reference Substances for In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 09-08-2005 05-17939 PDF
175 70 FR 66451 - Second Expert Panel Report on In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 11-01-2005 05-21830 PDF
176 70 FR 68069 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 11-08-2005 05-22320 PDF
177 70 FR 9661 - Second Request for Data on Chemicals Evaluated by In Vitro or In Vivo Ocular Irritancy Test Methods 02-25-2005 05-3831 PDF
178 70 FR 13512 - Request for Data on Non-Animal Methods and Approaches for Determining Skin and Eye Irritation Potential of Antimicrobial Cleaning Product Formulations; Request for Nominations for an Independent Expert Panel 03-21-2005 05-5471 PDF
179 70 FR 13513 - Availability of Expert Panel Report on the Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 03-21-2005 05-5473 PDF
180 70 FR 14473 - Request for Nominations for an Independent Peer Review Panel to Evaluate In Vitro Testing Methods for Estimating Acute Oral Systemic Toxicity and Request for In Vivo and In Vitro Data 03-22-2005 05-5564 PDF
181 70 FR 18037 - Ocular Toxicity Scientific Symposia: Mechanisms of Chemically-Induced Ocular Injury and Recovery and Minimizing Pain and Distress in Ocular Toxicity Testing 04-07-2005 05-7002 PDF
182 64 FR 6111 - Meeting of the Advisory Committee on Alternative Toxicological Methods 02-08-1999 99-24121 PDF
183 Validation and Acceptance of Alternative Testing Methods; Request for Comments 12-07-1994 94-30023 PDF
184 62 FR 48290 - Notice of Establishment 09-12-1997 97-24273 PDF
185 62 FR 11901 - Validation and Regulatory Acceptance of Toxicological Test methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods, Now Available 03-12-1997 97-6288 PDF
186 63 FR 37405 - Notice of Meeting to Review the Murine Local Lymph Node Assay (LLNA) as an Alternative Test Method for Contact Hypersensitivity; Request for Comments 07-09-1998 98-18320 PDF
187 63 FR 40303 - Request for Comments on Test Methods Undergoing Review by the Interagency Coordinating Committee on the Validation fo Alternative Methods (ICCVAM) and the National Toxicology Program Interagency Center for the Evaluation of Alternative Methods 07-27-1998 98-20040 PDF
188 63 FR 57303 - Notice of Meeting to Review the Corrositex(R) Assay as an Alternative Test Method for Assessing the Skin Corrosivity Potential of Chemicals; Request for Comments 10-26-1998 98-28713 PDF
189 64 FR 33109 - Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential fo Chemicals, Report Now Available 06-18-1999 99-15725 PDF
190 64 FR 48662 - Request for Data and Suggested Expert Panelists for Evaluation of the Current Status of the Frog Embryo Teratogenesis Assay--Xenopus (FETAX) 09-03-1999 99-23219 PDF
191 64 FR 50297 - Meeting of the Advisory Committee on Alternative Toxicological Methods 09-15-1999 99-24121 PDF
192 64 FR 67579 - Availability and Request for Comments on the Revised Guidance Document: Evaluation of the Validation Status of Toxicological Methods: General Guidelines for Submissions to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 12-01-1999 99-31342 PDF
193 64 FR 14006 - The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds, Report Now Available 03-22-1999 99-6953 PDF
194 64 FR 18040 - National Toxicology Program Special Emphasis Panel; Notice of Meeting 04-12-1999 99-9099 PDF
195 66 FR 46066 - The Revised Draft Up-and-Down Procedure for Assessing Acute Oral Toxicity; Notice of Availability and Request for Public Comments: CORRECTION 08-30-2001 C1-15770 PDF
196 70 FR 74833 - Peer Panel Evaluation of In Vitro Pyrogenicity Testing Methods: Request for Comments, Nominations of Experts, and Submission of In Vivo and In Vitro Data 12-15-2005 E5-7410 PDF
197 71 FR 4603 - Nomination to Hold a Workshop on Alternative Methods to Replace the Mouse LD50 Assay for Botulinum Toxin Potency Testing: Request for Comments, Nominations of Experts, and Submission of In Vivo and In Vitro Data 01-26-2006 E6-1019 PDF
198 71 FR 39122 - Availability of Peer Review Panel Report on the Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing and Request for Comments 07-10-2006 E6-10789 PDF
199 71 FR 39121 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 07-10-2006 E6-10790 PDF
200 71 FR 47505 - Scientific Workshop on Alternative Methods to Refine, Reduce, or Replace the Mouse LD50 Assay for Botulinum Toxin Testing; Request for In Vivo and In Vitro Data 08-16-2006 E6-13525 PDF
201 71 FR 56997 - Notice of Availability of a Revised List of Recommended Reference Substances for Validation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays 09-27-2006 E6-15972 PDF
202 71 FR 60748 - Notice of Availability of the NICEATM Pre-Screen Evaluation of a Cell Proliferation Assay to Detect Estrogenic Activity: Request for Comments and Nominations of Other In Vitro Endocrine Disruptor Test Methods 10-13-2006 E6-17134 PDF
203 71 FR 62480 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 10-25-2006 E6-17889 PDF
204 71 FR 66172 - Development of a NICEATM/ICCVAM 5-Year Plan to Research, Develop, Translate, and Validate New and Revised Non-animal and Other Alternative Assays for Integration of Relevant and Reliable Methods into Federal Agency Testing Programs: Request for Public Comments 11-09-2006 E6-19094 PDF
205 71 FR 66959 - Availability of Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 11-16-2006 E6-19487 PDF
206 71 FR 74533 - Announcement of an Independent Scientific Peer Review Meeting on the Use of In Vitro Pyrogenicity Testing Methods; Request for Comments 12-11-2006 E6-21038 PDF
207 71 FR 13597 - Notice of Availability of a Revised List of Recommended Reference Substances for Validation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays: Request for Comments and Submission of In Vivo and In Vitro Data 03-15-2006 E6-3763 PDF
208 71 FR 14229 - Announcement of an Independent Scientific Peer Review Meeting on the Use of In Vitro Testing Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests and Request for Comments 03-20-2006 E6-4075 PDF
209 72 FR 31582 - Request for Ocular Irritancy Test Data From Human, Rabbit, and In Vitro Studies Using Standardized Testing Methods 06-07-2007 E7-10966 PDF
210 72 FR 52130 - Draft Performance Standards for the Murine Local Lymph Node Assay: Request for Comments 09-12-2007 E7-18011 PDF
211 72 FR 65964 - Availability of TMER and Final BRDs on In Vitro Ocular Test Methods; Recommendations to Federal Agencies 11-26-2007 E7-22906 PDF
212 72 FR 72727 - Ten-Year Anniversary Symposium and Five-Year Plan 12-21-2007 E7-24799 PDF
213 73 FR 493 - Workshop on Acute Chemical Safety Testing 01-03-2008 E7-25536 PDF
214 73 FR 1360 - Announcement of an Independent Scientific Peer Review Panel Meeting on the Murine Local Lymph Node Assay; Availability of Draft Background Review Documents; Request for Comments 01-08-2008 E7-25553 PDF
215 72 FR 23831 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 05-01-2007 E7-8289 PDF
216 72 FR 23832 - Availability of Draft NICEATM-ICCVAM 5-Year Plan and Request for Public Comments; Announcement of a Town Meeting on the Draft NICEATM-ICCVAM 5-Year Plan 05-01-2007 E7-8290 PDF
217 72 FR 26395 - Peer Review Panel Report on Five In Vitro Pyrogen Test Methods: Availability and Request for Public Comments 05-09-2007 E7-8896 PDF
218 72 FR 26396 - Request for Data on the Use of Topical Anesthetics and Systemic Analgesics for In Vivo Eye Irritation Testing 05-09-2007 E7-8898 PDF
219 72 FR 27815 - The Murine Local Lymph Node Assay: Request for Comments, Nominations of Scientific Experts, and Submission of Data 05-17-2007 E7-9544 PDF
220 73 FR 15757 - Availability of the ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests and the Final Background Review Document for In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity; Notice of Transmittal of ICCVAM Test Method Recommendations to Federal Agencies 03-25-2008 E8-5936 PDF
221 OECD Guidance Document 125: Histopathology for Subacute and Subchronic Inhalation Toxicity Studies 06-01-2010 OECD GD 125 PDF
222 OECD Series on Testing and Assessment No. 126: Short Guidance on the Threshold Approach for Acute Fish Toxicity 05-31-2010 OECD GD 126 PDF
223 OECD Guidance Document 160: The BCOP and ICE Test Methods: Collection of Tissues for Histological Evaluation and Collection of Data on Non-severe Irritants 10-25-2011 OECD GD 160 PDF
224 OECD Guidance Document 24: Acute Oral Toxicity Testing 07-23-2001 OECD GD 24 PDF
225 OECD Guidance Document 34: Validation and International Acceptance of New or Updated Internationally Acceptable Test Methods for Hazard Assessment 08-18-2005 OECD GD 34 PDF
226 OECD Guidance Document 39: Acute Inhalation Toxicity Testing 07-21-2009 OECD GD 39 PDF
227 OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring Number 14 - The Application of the Principles of GLP to in vitro Studies 11-30-2004 OECD GLP14 PDF
228 OECD Test Guideline 403: Acute Inhalation Toxicity 09-07-2009 OECD TG 403 PDF
229 OECD Test Guideline 405: Acute Eye Irritation/Corrosion (updated 2012) 04-24-2002 OECD TG 405 PDF
230 OECD Test Guideline 412: Subacute Inhalation Toxicity: 28-day Study 09-07-2009 OECD TG 412 PDF
231 OECD Test Guideline 413: Subchronic Inhalation Toxicity: 90-day Study 09-07-2009 OECD TG 413 PDF
232 OECD Test Guideline 429: Skin Sensitisation: Local Lymph Node Assay 07-22-2010 OECD TG 429 PDF
233 OECD Test Guideline 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER) 07-26-2013 OECD TG 430 PDF
234 OECD Test Guideline 436: Acute Inhalation Toxicity - Acute Toxic Class Method 09-07-2009 OECD TG 436 PDF
235 OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage 07-26-2013 OECD TG 437 PDF
236 OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage 07-26-2013 OECD TG 438 PDF
237 OECD Test Guideline 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method 07-26-2013 OECD TG 439 PDF
238 OECD Test Guideline 441: Hershberger Bioassay in Rats: A Short-term Screening Assay for (Anti)Androgenic Properties 09-07-2009 OECD TG 441 PDF
239 OECD Test Guideline 442A: Skin Sensitization: Local Lymph Node Assay: DA 07-22-2010 OECD TG 442A PDF
240 OECD Test Guideline 442B: Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA 07-22-2010 OECD TG 442B PDF
241 OECD Test Guideline 443: Extended One-Generation Reproductive Toxicity Study 10-02-2012 OECD TG 443 PDF
242 OECD Test Guideline 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists (updated 2012) 09-07-2009 OECD TG 455 PDF
243 OECD Test Guideline 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists 10-02-2012 OECD TG 457 PDF
244 OECD Test Guideline 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants 10-02-2012 OECD TG 460 PDF
245 OECD Guidance Document 19: Recognition, Assessment and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation 11-01-2000 OECD GD 19 PDF
246 OECD Test Guideline 414: Prenatal Development Toxicity Study 01-22-2001 OECD TG 414 PDF
247 OECD Test Guideline 420: Acute Oral Toxicity - Fixed Dose Procedure 12-17-2001 OECD TG 420 PDF
248 OECD Test Guideline 421: Reproduction/Developmental Toxicity Screening Test 07-27-1995 OECD TG 421 PDF
249 OECD Test Guideline 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test 03-22-1996 OECD TG 422 PDF
250 OECD Test Guideline 423: Acute Oral toxicity - Acute Toxic Class Method 12-17-2001 OECD TG 423 PDF
251 OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring Number 1: OECD Principles on GLP 01-26-1998 OECD GD 1 PDF
252 Final Report of the OECD Workshop on Harmonisation of Validation and Acceptance Criteria for Alternative to Toxicological Test Methods 10-01-1994 NA PDF
253 OECD Test Guideline 404: Acute Dermal Irritation/Corrosion 04-24-2002 OECD TG 404 PDF
254 OECD Test Guideline 406: Skin Sensitization 07-17-1992 OECD TG 406 PDF
255 OECD Test Guideline 407: Repeated 28-day Oral Toxicity Study in Rodents 10-03-2008 OECD TG 407 PDF
256 OECD Test Guideline 425: Acute Oral Toxicity - Up-and-Down Procedure (UDP) 03-23-2006 OECD TG 425 PDF
257 OECD Test Guideline 428: Skin Absorption In Vitro Method 04-13-2004 OECD TG 428 PDF
258 OECD Test Guideline 432: In Vitro 3T3 NRU Phototoxicity Test 04-13-2004 OECD TG 432 PDF
259 OECD Test Guideline 435: In Vitro Membrane Barrier Test Method for Skin Corrosion 07-19-2006 OECD TG 435 PDF
260 OECD Test Guideline 440: Uterotrophic Bioassay in Rodents: A short-term screening test for oestrogenic properties 10-16-2007 OECD TG 440 PDF
261 USDA, Center for Veterinary Biologics Notice: Use of Humane Endpoints in Animal Testing of Biological Products 04-01-2004 USDA CVB 04-09 PDF
262 Supplemental Assay Method 613: In Vitro Potency Testing of Erysipelothrix rhusiopathie Bacterins 02-12-2010 SAM 613 PDF
263 Supplemental Assay Method 624: In Vitro Potency Testing of Leptospira interrogans Serovar pomona Bacterins 06-03-2009 SAM 624 PDF
264 Supplemental Assay Method 625: In Vitro Potency Testing of Leptospira interrogans Serovar canicola Bacterins 06-03-2009 SAM 625 PDF
265 Supplemental Assay Method 626: In Vitro Potency Testing of Leptospira kirschneri Serogroup grippotyphosa Bacterins 07-28-2011 SAM 626 PDF
266 Supplemental Assay Method 627: In Vitro Potency Testing of Leptospira interrogans Serovar icterohaemorrhagiae Bacterins 06-03-2009 SAM 627 PDF
267 9 CFR 113.110: Animal and Plant Health Inspection Service, USDA: Clostridium Botulinum Type C Bacterin-Toxoid 01-01-2003 9 CFR 113.110 PDF
268 Veterinary Services Memo No. 800.211: Guidelines for Master Reference Qualification and Requalification 06-28-2011 VS 800.211 PDF



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