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Principal Investigator: Rosen, Barry P.
Institute Receiving Award Florida International University
Location Miami, FL
Grant Number R01ES023779
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 11 Dec 2014 to 30 Nov 2021
DESCRIPTION (provided by applicant): : The Environmental Protection Agency calls arsenic the most prevalent environmental toxin and carcinogen in the United States (:// Arsenic causes cardiovascular and peripheral vascular diseases, neurological disorders, diabetes mellitus and various forms of cancer such as skin and bladder cancer. Arsenic is biomethylated by the liver enzyme As (III) S-adenosylmethionine (SAM) methyltransferase (AS3MT) to mono- and dimethylated species. Because the trivalent products methylarsenite (MAs(III)) and dimethylarsenite (DMAs(III)) are more toxic than inorganic arsenite, they have been proposed to be associated with arsenic carcinogenesis and other diseases in humans. Individuals with AS3MT polymorphisms produce increased amounts of methylated species. How methylation contributes to disease depends on the mechanism of human AS3MT and differences between wild type and polymorphic enzymes. The uncertainty over the consequences of methylation makes it imperative to understand how this enzyme works. The overall goal of this study is elucidation of the structure and function of hAS3MT and its polymorphic forms.
Science Code(s)/Area of Science(s) Primary: 10 - Epigenetics
Publications See publications associated with this Grant.
Program Officer Frederick Tyson
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