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Your Environment. Your Health.

MECHANISM OF GENE ENVIRONMENT INTERACTIONS IN ALZHEIMER'S DISEASE

Export to Word (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantdetail/grant_number/R01ES026057/format/word)
Principal Investigator: Richardson, Jason R
Institute Receiving Award Florida International University
Location Miami, FL
Grant Number R01ES026057
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 27 Oct 2018 to 30 Jun 2021
DESCRIPTION (provided by applicant): Using well-characterized clinical cohorts, we recently reported that serum levels of DDE, the metabolite of the organochlorine pesticide DDT is significantly higher in the serum of Alzheimer Disease (AD) cases and is associated with increased risk of AD diagnosis. Further, individuals harboring a polymorphism in APOE and having high serum levels of DDE performed worse on a cognitive task than either those with just the polymorphism or high DDE levels. Finally, we identified that DDT and DDE increase levels of amyloid precursor protein (APP), suggesting a possible mechanism by which DDT exposure may contribute to ADBased on our initial findings, the goals of this project include: (1) identifying the mechanism by which DDT exposure increases APP levels; (2) determining the effect of APOE genetic status on the effects of DDT on Aβ accumulation and oligomerization; and (3) assessing the effects of DDT exposure on AD pathology and behavioral dysfunction in transgenic mouse models humanized for APOE polymorphisms. We will achieve these goals using a combination of cutting edge techniques including epigenetic analysis, patient-specific stem cells, and transgenic mice harboring human polymorphisms.
Science Code(s)/Area of Science(s) Primary: 63 - Neurodegenerative
Publications See publications associated with this Grant.
Program Officer Jonathan Hollander
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