Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.


Export to Word (
Principal Investigator: Miranda, Marie Lynn
Institute Receiving Award University Of Notre Dame
Location Notre Dame, IN
Grant Number R01ES028819
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 30 Sep 2020 to 31 Jan 2022
DESCRIPTION (provided by applicant): Project Summary: Bringing Modern Data Science Tools to Bear on Environmental Mixtures Environmental exposures often cumulate in particular geographies, and the nature of the complex mixtures that characterize these exposures remains understudied. In addition, adverse environmental exposures often occur in communities facing multiple social stressors such as deteriorating housing, inadequate access to health care, poor schools, high unemployment, crime, and poverty – all of which may compound the effects of environmental exposures. Our central objective is to develop new data architecture, statistical, and machine learning methods to assess how exposure to environmental mixtures shapes educational outcomes in the presence or absence of social stress. We focus on air pollution mixtures, childhood lead exposure, and social stressors. We will implement our proposed work in North Carolina (NC), a state characterized by diverse environmental features, industrial activities, and airsheds typified by varying pollution emission sources and resulting pollutant mixtures. To accomplish this central objective, we will first develop, document, and disseminate methods for building space-time environmental and social data architectures. We will implement this for all of NC, incorporating data on air pollution, lead exposure risk, and social exposures from 1990-2015+ (dataset 1). Second, we will refine methods for linking unrelated datasets to build a space-time child movement and outcome data architecture (dataset 2). Third, we will connect exposures (dataset 1) and outcomes (dataset 2) data via shared geography and temporality into a single, comprehensive geodatabase. Fourth, we will implement increasingly complex methods to assess the effect of environmental mixtures in the presence or absence of social stressors on early childhood educational outcomes. We will document and disseminate all of the underlying methodological work via public website. The proposed work leverages a rich array of data resources already available to the investigators (with some significantly post-processed) and allows tracking of children across space and time. Our team brings tools from modern data science (hierarchical Bayesian methods with variable selection, spatial point process models, machine learning) to bear on the critical question of how environmental mixtures shape child outcomes directly and differentially in the presence of social stress.
Science Code(s)/Area of Science(s) Primary: 16 - Mixtures
Publications No publications associated with this grant
Program Officer Bonnie Joubert
to Top