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Your Environment. Your Health.

NRF1-DEPENDENT REGULATION OF CELLULAR STRESS RESPONSE YOUR TITLE

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Principal Investigator: Chan, Jefferson Y
Institute Receiving Award University Of California-Irvine
Location Irvine, CA
Grant Number R01ES029481
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 01 Aug 2019 to 30 Apr 2024
DESCRIPTION (provided by applicant): Project abstract The goal of this project is to understand the role Nrf1 in cellular stress response pathway. We hypothesize that depending on the type of stimuli, different Nrf1 isoforms regulate different adaptive responses (oxidative, ER, proteotoxic) to cellular stress. We will first determine stress-activated genes that are controlled by Nrf1 and its isoforms. Next, we will use genome-wide approaches that will permit comprehensive, and quantitative analyses to investigate redundancy and specificity between Nrf1 and Nrf2 in mediating cellular stress responses. Third, we will delineate mechanisms by which Nrf1 is regulated. Our findings should have broad and significant impact on our understanding of cellular stress response pathways.
Science Code(s)/Area of Science(s) Primary: 01 - Basic Cellular or Molecular processes
Publications No publications associated with this grant
Program Officer Daniel Shaughnessy
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