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Your Environment. Your Health.

IMPACTS OF BENZO[A]PYRENE ON MICROBIOME DEVELOPMENT ACROSS LIFESPAN AND GENERATIONS AND THE BEHAVIORAL CONSEQUENCES

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Principal Investigator: Sharpton, Thomas Jefferson
Institute Receiving Award Oregon State University
Location Corvallis, OR
Grant Number R01ES030226
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 01 Feb 2019 to 31 Jan 2024
DESCRIPTION (provided by applicant): Project Summary / Abstract This project will test the innovative hypothesis that developmental exposure to environmental toxicants can alter gut microbiome assembly and succession to consequently result in impaired behavior and cognition. The alarming rise in behavioral and cognitive disorders is linked to early life exposure to environmental chemicals, such as benzo[a]pyrene (BAP), the globally ubiquitous pollutant on which this project focuses. While the mechanisms underlying these impairments remain poorly defined, prior work implicates a dysbiotic gut microbiome. This project will define how early life exposure to BAP alters the development of gut microbiome structure and function and how these alterations relate to behavior. It will also couple high-throughput culturing with a scalable, germ-free animal model (zebrafish) to comprehensively measure the behavioral impacts of BAP-sensitive gut microbes and their metabolites. This project also quantifies how developmental BAP exposure alters the microbiome-behavior axis in subsequent generations. Consequently, the proposed research holds great potential to transform our understanding of the causes of behavior impairment and reveal new candidates, in the forms of gut microbes and metabolites, for normalizing behavior development.
Science Code(s)/Area of Science(s) Primary: 68 - Microbiome
Secondary: 03 - Carcinogenesis/Cell Transformation
Publications See publications associated with this Grant.
Program Officer Anika Dzierlenga
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