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| Principal Investigator: Wondrak, Georg T | |
|---|---|
| Institute Receiving Award | University Of Arizona |
| Location | Tucson, AZ |
| Grant Number | R21ES029579 |
| Funding Organization | National Institute of Environmental Health Sciences |
| Award Funding Period | 01 Apr 2019 to 31 Mar 2021 |
| DESCRIPTION (provided by applicant): | PROJECT SUMMARY Hypochlorous acid (HOCl) is the active oxidizing principle released by standard swimming pool disinfectants used on a global scale, but the health consequences of human exposure inflicted by HOCl remain largely unknown, posing a major public health concern relevant to populations around the world. Environmental exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis, and immune suppression is a key mechanism underlying detrimental effects of acute and chronic UV exposure. Based on our prototype experiments, the proposed research will explore the molecular potentiation of UV-induced cutaneous and systemic damage by co-exposure to HOCl-based swimming pool disinfectants, examined in cell culture, skin tissue models, and mouse models of UV-induced skin damage and cancer. First, we will define the specific molecular mechanisms underlying HOCl-potentiation of solar UV-induced oxidative insult and genotoxic stress, examined in cultured skin cells and human epidermal tissue reconstructs (aim #1). Next, we will explore the potentiating role of HOCl co-exposure in established murine models of UV-induced acute photodamage (sunburn), systemic photoimmunosuppression, and photocarcinogenesis (aim #2). The |
| Science Code(s)/Area of Science(s) | Primary: 58 - Skin |
| Publications | See publications associated with this Grant. |
| Program Officer | Michael Humble |