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Your Environment. Your Health.

EXPLORING THE ROLE OF HOCI IN SKIN PHOTODAMAGE, IMMUNOSUPPRESSION, AND CARCINOGENESIS

Export to Word (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantdetail/grant_number/R21ES029579/format/word)
Principal Investigator: Wondrak, Georg T
Institute Receiving Award University Of Arizona
Location Tucson, AZ
Grant Number R21ES029579
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 01 Apr 2019 to 31 Mar 2021
DESCRIPTION (provided by applicant): PROJECT SUMMARY Hypochlorous acid (HOCl) is the active oxidizing principle released by standard swimming pool disinfectants used on a global scale, but the health consequences of human exposure inflicted by HOCl remain largely unknown, posing a major public health concern relevant to populations around the world. Environmental exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis, and immune suppression is a key mechanism underlying detrimental effects of acute and chronic UV exposure. Based on our prototype experiments, the proposed research will explore the molecular potentiation of UV-induced cutaneous and systemic damage by co-exposure to HOCl-based swimming pool disinfectants, examined in cell culture, skin tissue models, and mouse models of UV-induced skin damage and cancer. First, we will define the specific molecular mechanisms underlying HOCl-potentiation of solar UV-induced oxidative insult and genotoxic stress, examined in cultured skin cells and human epidermal tissue reconstructs (aim #1). Next, we will explore the potentiating role of HOCl co-exposure in established murine models of UV-induced acute photodamage (sunburn), systemic photoimmunosuppression, and photocarcinogenesis (aim #2). The
Science Code(s)/Area of Science(s) Primary: 58 - Skin
Publications See publications associated with this Grant.
Program Officer Michael Humble
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