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Your Environment. Your Health.

PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS) IN MARINE FISH AND SHELLFISH: A BIOMONITORING TOOL FOR PFAS REMEDIATION AND A METRIC FOR POTENTIAL HUMAN EXPOSURE THROUGH SEAFOOD CONSUMPTION

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Principal Investigator: Chen, Celia Y
Institute Receiving Award Dartmouth College
Location Hanover, NH
Grant Number R21ES032187
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 11 Sep 2020 to 31 Aug 2022
DESCRIPTION (provided by applicant): PROJECT SUMMARY With concerns about human exposure to per- and polyfluoroalkyl substances (PFASs) on the rise, regional data about PFASs in various environmental media are needed to inform enforceable and protective standards for common routes of exposure, including seafood consumption. PFASs are persistent environmental contaminants of particular concern for vulnerable and sensitive populations, including children and pregnant women. Four PFASs are commonly detected in blood from United States (US) residents: perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS). Animal and epidemiologic studies support a role for PFAS effects on the thyroid, liver, cholesterol, and even cancer risk. Human exposure to PFASs occurs primarily through ingestion, notably via PFAS contaminated drinking water and diet. These contaminants pose a regional as well as national threat to surface water and drinking water supplies with detections occurring in 49 states. PFASs in fish and shellfish, particularly in freshwater ecosystems, are recognized as an important dietary source of exposure, but data regarding exposures from marine sourced seafood are limited, hindering the development of health protective standards. In the northeastern United States (US), where an abundance of PFAS contamination sites have been identified and seafood consumption rates tend to be high relative to other regions of the US, marine species comprise a considerable share of the market. In New Hampshire (NH), the PFAS landscape is rapidly evolving with implementation of regulatory limits on drinking water supplies, investigation and remediation efforts at affected sites, and ongoing efforts to monitor exposed communities. As regulations of PFAS use evolve and remediation commences at contaminated sites, seafood monitoring will be integral to evaluating effectiveness of policies and remediation activities. There is an urgent need to collect human exposure data in order to provide critical information to understand the PFAS exposure-health outcome relationship. The proposed research encompasses both measurements of PFASs in regionally sourced, commonly consumed marine seafood species, and an assessment of local seafood consumption habits to help meet this need. The research will be conducted by a highly interdisciplinary team of scientists (marine biologists, epidemiologists, toxicologists, environmental chemists) involving a collaboration between the NH Department of Environmental Services and Dartmouth College. The project will leverage a unique archive of existing fish and shellfish tissue samples harvested throughout the Gulf of Maine (GOM), as well as new samples collected in Great Bay (GB) adjacent to a PFAS contamination site at the Pease Air Force Base. Furthermore, the proposed research will take advantage of the start of active PFAS remediation at the Pease Air Force Base to evaluate remedial effectiveness based on PFAS concentrations in the neighboring GB. The research project is proposed to provide time critical data to support timely action to protect public health in the GOM region.
Science Code(s)/Area of Science(s) Primary: 25 - Superfund Basic Research (non- P42 center grants)
Secondary: 03 - Carcinogenesis/Cell Transformation
Publications No publications associated with this grant
Program Officer Heather Henry
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