Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

THE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTER

Export to Word (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantdetail/grant_number/U24ES026699/format/word)
Principal Investigator: Wang, Ting
Institute Receiving Award Washington University
Location St. Louis, MO
Grant Number U24ES026699
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 01 Jul 2016 to 30 Jun 2021
DESCRIPTION (provided by applicant):  : The goals of the WashU TaRGET Environmental Epigenomics Data Coordination Center (TaRGET T2C DCC) component to the TaRGET Consortium are to collect, store, curate, and display all data, metadata, and analysis tools generated by the TaRGET. The DCC will also assist in the development and dissemination of metadata and standards to be adopted by the community at large, approaches for integrative analysis of a wide-range of data types, and visualization and analysis tools to facilitate access and understanding of complex datasets to non-expert users. Ultimately, the TaRGET Consortium will produce tools, analysis, models, and data that form the reference maps of the environmental exposure related epigenomes of different cells and tissues, and we will develop the DCC into a substantial service organization allowing scientific research to take full advantage of the TaRGET reference maps. To support the TaRGET Consortium, we will establish databases with an application framework to facilitate complex data loading including detailed experimental descriptions and metadata; we will define and establish pipelines that connect all Consortium members to the data, and create avenues of access that distribute the data to the greater biological research community; we will establish metadata requirements, controlled vocabularies, standardized data formats, and quality control metrics for all TaRGET data; we will bring together laboratories that generate complex data types via experimental assays with laboratories that integrate these data using computational tools to define the epigenomic programs in the context of environmental exposure. Through the creation of structures data flow pipelines for the verification and validation of all data, and providing processes for the documentation of metadata, the DCC will enhance the TaRGET data production. The DCC will also coordinate integrative data analysis by creating and adapting analysis pipelines, and by developing advanced Genome Browser functions for the visual integration of TaRGET data. In addition, we will create TaRGET Data Portal that will be the primary entry point to the wealth of experimental data as well as computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Finally, the DCC will provide documentation, training, and outreach via many media including written documentation, video tutorials, online books, webinars, and meeting workshops and presentations.
Science Code(s)/Area of Science(s) Primary: 10 - Epigenetics
Publications See publications associated with this Grant.
Program Officer Christopher Duncan
Back
to Top