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Who We Fund: Publication Detail

Project Title: ITERATIVE POLYKETIDE SYNTHASE FUNCTION, STRUCTURE AND PATHWAYS
PI: Townsend, Craig Arthur
Institution: Johns Hopkins University
Grant Number: R01ES001670

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Viewing 57 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Examining Heterodimerization by Aryl C-N Coupling in Dynemicin Biosynthesis.   Pal, Paramita; Alley, Jamie R; Townsend, Craig A R01ES001670, R01ES001670 ACS Chem Biol (2023 Feb 17) 36696117 Exiting the NIEHS site 2023 
C-N-Coupled Metabolites Yield Insights into Dynemicin A Biosynthesis.   Cohen, Douglas R; Townsend, Craig A R01ES001670, R01ES001670 Chembiochem (2020 08 03) 32198800 Exiting the NIEHS site 2020 
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis.   Cohen, Douglas R; Townsend, Craig A R01ES001670, R01ES001670 Nat Chem (2018 Feb) 29359752 Exiting the NIEHS site 2018 
Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis.   Cohen, Douglas R; Townsend, Craig A R01ES001670, R01ES001670 Angew Chem Int Ed Engl (2018 May 14) 29512267 Exiting the NIEHS site 2018 
Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacety ...   Saraiva, Raúl G; Huitt-Roehl, Callie R; Tripathi, Abhai; Cheng, Yi-Qiang; Bosch, Jürgen; Townse ... R01ES001670, R01ES001670 Sci Rep (2018 04 18) 29670144 Exiting the NIEHS site 2018 
Exploring Fungal Polyketide C-Methylation through Combinatorial Domain Swaps.   Storm, Philip A; Pal, Paramita; Huitt-Roehl, Callie R; Townsend, Craig A R01ES001670, R01ES001670 ACS Chem Biol (2018 11 16) 30350943 Exiting the NIEHS site 2018 
Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to t ...   de Jonge, Ronnie; Ebert, Malaika K; Huitt-Roehl, Callie R; Pal, Paramita; Suttle, Jeffrey C; Sp ... R01ES001670, R01ES001670 Proc Natl Acad Sci U S A (2018 06 12) 29844193 Exiting the NIEHS site 2018 
The architectures of iterative type I PKS and FAS.   Herbst, Dominik A; Townsend, Craig A; Maier, Timm R01ES001670, R01ES001670 Nat Prod Rep (2018 Oct 17) 30137093 Exiting the NIEHS site 2018 
The structural organization of substrate loading in iterative polyketide synthases.   Herbst, Dominik A; Huitt-Roehl, Callie R; Jakob, Roman P; Kravetz, Jacob M; Storm, Philip A; Al ... R01ES001670, R01ES001670 Nat Chem Biol (2018 05) 29610486 Exiting the NIEHS site 2018 
Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Pol ...   Storm, Philip A; Herbst, Dominik A; Maier, Timm; Townsend, Craig A R01ES001670, R01ES001670 Cell Chem Biol (2017 Mar 16) 28238725 Exiting the NIEHS site 2017 
In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis ...   Storm, Philip A; Townsend, Craig A R01ES001670, R01ES001670 Chem Commun (Camb) (2017 Dec 19) 29189834 Exiting the NIEHS site 2017 
Polyketide mimetics yield structural and mechanistic insights into product template domain function ...   Barajas, Jesus F; Shakya, Gaurav; Moreno, Gabriel; Rivera Jr, Heriberto; Jackson, David R; Topp ... R01ES001670, R01ES001670 Proc Natl Acad Sci U S A (2017 May 23) 28484029 Exiting the NIEHS site 2017 
Molecular Characterization of the Cercosporin Biosynthetic Pathway in the Fungal Plant Pathogen Cerc ...   Newman, Adam G; Townsend, Craig A R01ES001670, R01ES001670 J Am Chem Soc (2016 Mar 30) 26938470 Exiting the NIEHS site 2016 
Quenching of pH-Responsive Luminescence of a Benzoindolizine Sensor by an Ultrafast Hydrogen Shift.   Zhou, Jiawang; Outlaw, Victor K; Townsend, Craig A; Bragg, Arthur E R01ES001670, R01ES001670 Chemistry (2016 Oct 17) 27549912 Exiting the NIEHS site 2016 
Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein ...   Barajas, Jesus F; Finzel, Kara; Valentic, Timothy R; Shakya, Gaurav; Gamarra, Nathan; Martinez, ... R01ES001670, R01ES001670 Angew Chem Int Ed Engl (2016 Oct 10) 27653519 Exiting the NIEHS site 2016 
Unusual Blue-Shifted Acid-Responsive Photoluminescence Behavior in 6-Amino-8-cyanobenzo[1,2-b]indoli ...   Outlaw, Victor K; Zhou, Jiawang; Bragg, Arthur E; Townsend, Craig A R01ES001670, R01ES001670 RSC Adv (2016 Jul 08) 28580137 Exiting the NIEHS site 2016 
New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1.   Conradt, David; Schätzle, Michael A; Haas, Julian; Townsend, Craig A; Müller, Michael R01ES001670, R01ES001670 J Am Chem Soc (2015 Sep 02) 26266881 Exiting the NIEHS site 2015 
One-pot synthesis of highly substituted N-fused heteroaromatic bicycles from azole aldehydes.   Outlaw, Victor K; d'Andrea, Felipe B; Townsend, Craig A R01ES001670, R01ES001670 Org Lett (2015 Apr 17) 25815402 Exiting the NIEHS site 2015 
Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase Pks ...   Huitt-Roehl, Callie R; Hill, Eric A; Adams, Martina M; Vagstad, Anna L; Li, Jesse W; Townsend, ... R01ES001670, R01ES001670 ACS Chem Biol (2015 Jun 19) 25714897 Exiting the NIEHS site 2015 
A practical route to substituted 7-aminoindoles from pyrrole-3-carboxaldehydes.   Outlaw, Victor K; Townsend, Craig A R01ES001670, R01ES001670 Org Lett (2014 Dec 19) 25479249 Exiting the NIEHS site 2014 
Aflatoxin and deconstruction of type I, iterative polyketide synthase function.   Townsend, Craig A R01ES001670, R01ES001670 Nat Prod Rep (2014 Oct) 25079257 Exiting the NIEHS site 2014 
Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic underst ...   Newman, Adam G; Vagstad, Anna L; Storm, Philip A; Townsend, Craig A R01ES001670, R01ES001670 J Am Chem Soc (2014 May 21) 24815013 Exiting the NIEHS site 2014 
Active site comparisons and catalytic mechanisms of the hot dog superfamily.   Labonte, Jason W; Townsend, Craig A R01ES001670, R01ES001670 Chem Rev (2013 Mar 13) 23205964 Exiting the NIEHS site 2013 
Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed oct ...   Belecki, Katherine; Townsend, Craig A R01ES001670, R01ES001670 J Am Chem Soc (2013 Sep 25) 24041368 Exiting the NIEHS site 2013 
Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming ...   Vagstad, Anna L; Newman, Adam G; Storm, Philip A; Belecki, Katherine; Crawford, Jason M; Townse ... R01ES001670, R01ES001670 Angew Chem Int Ed Engl (2013 Feb 04) 23283670 Exiting the NIEHS site 2013 
Enzymology: Modular biosynthesis branches out.   Townsend, Craig A R01ES001670, R01ES001670 Nature (2013 Oct 03) 24048474 Exiting the NIEHS site 2013 
Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase ...   Bruegger, Joel; Haushalter, Robert W; Haushalter, Bob; Vagstad, Anna L; Vagstad, Anna; Shakya, ... R01ES001670, R01ES001670 Chem Biol (2013 Sep 19) 23993461 Exiting the NIEHS site 2013 
Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.   Newman, Adam G; Vagstad, Anna L; Belecki, Katherine; Scheerer, Jonathan R; Townsend, Craig A R01ES001670, R01ES001670 Chem Commun (Camb) (2012 Dec 14) 23108075 Exiting the NIEHS site 2012 
Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melan ...   Vagstad, Anna L; Hill, Eric A; Labonte, Jason W; Townsend, Craig A R01ES001670, R01ES001670 Chem Biol (2012 Dec 21) 23261597 Exiting the NIEHS site 2012 
Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, non ...   Foulke-Abel, Jennifer; Townsend, Craig A R01ES001670, R01ES001670 Chembiochem (2012 Sep 03) 22807303 Exiting the NIEHS site 2012 
Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed oc ...   Belecki, Katherine; Townsend, Craig A R01ES001670, R01ES001670 Angew Chem Int Ed Engl (2012 Nov 5) 23042574 Exiting the NIEHS site 2012 
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals stra ...   Vagstad, Anna L; Bumpus, Stefanie B; Belecki, Katherine; Kelleher, Neil L; Townsend, Craig A R01ES001670, R01ES001670 J Am Chem Soc (2012 Apr 18) 22452347 Exiting the NIEHS site 2012 
Polyketide proofreading by an acyltransferase-like enzyme.   Jensen, Katja; Niederkrüger, Holger; Zimmermann, Katrin; Vagstad, Anna L; Moldenhauer, Jana; Br ... R01ES001670, R01ES001670 Chem Biol (2012 Mar 23) 22444588 Exiting the NIEHS site 2012 
A "diels-alderase" at last.   Townsend, Craig A R01ES001670, R01ES001670 Chembiochem (2011 Oct 17) 21796752 Exiting the NIEHS site 2011 
Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Asperg ...   Ehrlich, Kenneth C; Chang, Perng-Kuang; Scharfenstein Jr, Leslie L; Cary, Jeffrey W; Crawford, ... R01ES001670, R01ES001670 FEMS Microbiol Lett (2010 Apr) 20158523 Exiting the NIEHS site 2010 
New insights into the formation of fungal aromatic polyketides.   Crawford, Jason M; Townsend, Craig A R01ES001670, R01ES001670 Nat Rev Microbiol (2010 Dec) 21079635 Exiting the NIEHS site 2010 
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cy ...   Korman, Tyler Paz; Crawford, Jason M; Labonte, Jason W; Newman, Adam G; Wong, Justin; Townsend, ... R01ES001670, R01ES001670 Proc Natl Acad Sci U S A (2010 Apr 06) 20332208 Exiting the NIEHS site 2010 
Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for t ...   Belecki, Katherine; Crawford, Jason M; Townsend, Craig A R01ES001670, R01ES001670 J Am Chem Soc (2009 Sep 9) 19689130 Exiting the NIEHS site 2009 
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.   Crawford, Jason M; Korman, Tyler P; Labonte, Jason W; Vagstad, Anna L; Hill, Eric A; Kamari-Bid ... R01ES001670, R01ES001670 Nature (2009 Oct 22) 19847268 Exiting the NIEHS site 2009 
Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases.   Crawford, Jason M; Vagstad, Anna L; Ehrlich, Kenneth C; Udwary, Daniel W; Townsend, Craig A R01ES001670, R01ES001670 Chembiochem (2008 Jul 02) 18551496 Exiting the NIEHS site 2008 
Deconstruction of iterative multidomain polyketide synthase function.   Crawford, Jason M; Thomas, Paul M; Scheerer, Jonathan R; Vagstad, Anna L; Kelleher, Neil L; Tow ... R01ES001670, R01ES001670 Science (2008 Apr 11) 18403714 Exiting the NIEHS site 2008 
Starter unit specificity directs genome mining of polyketide synthase pathways in fungi.   Crawford, Jason M; Vagstad, Anna L; Ehrlich, Kenneth C; Townsend, Craig A R01ES001670, R01ES001670 Bioorg Chem (2008 Feb) 18215412 Exiting the NIEHS site 2008 
Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "st ...   Crawford, Jason M; Vagstad, Anna L; Whitworth, Karen P; Ehrlich, Kenneth C; Townsend, Craig A R01ES001670, R01ES001670 Chembiochem (2008 May 05) 18338425 Exiting the NIEHS site 2008 
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I pol ...   Crawford, Jason M; Dancy, Blair C R; Hill, Eric A; Udwary, Daniel W; Townsend, Craig A R01ES001670, R01ES001670 Proc Natl Acad Sci U S A (2006 Nov 07) 17071746 Exiting the NIEHS site 2006 
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yie ...   Henry, Kevin M; Townsend, Craig A R01ES001670, R01ES001670 J Am Chem Soc (2005 Mar 23) 15771506 Exiting the NIEHS site 2005 
Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin.   Henry, Kevin M; Townsend, Craig A R01ES001670, R01ES001670 J Am Chem Soc (2005 Mar 16) 15755146 Exiting the NIEHS site 2005 
A method for prediction of the locations of linker regions within large multifunctional proteins, an ...   Udwary, Daniel W; Merski, Matthew; Townsend, Craig A R01ES001670, R01ES001670 J Mol Biol (2002 Oct 25) 12381311 Exiting the NIEHS site 2002 
Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex ...   Watanabe, Coran M H; Townsend, Craig A R01ES001670, R01ES001670 Chem Biol (2002 Sep) 12323372 Exiting the NIEHS site 2002 
Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulan ...   Keller, N P; Watanabe, C M; Kelkar, H S; Adams, T H; Townsend, C A R01ES001670, R01ES001670 Appl Environ Microbiol (2000 Jan) 10618248 Exiting the NIEHS site 2000 
Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus ...   Silva, J C; Townsend, C A R01ES001670, R01ES001670 J Biol Chem (1997 Jan 10) 8995367 Exiting the NIEHS site 1997 
Structural studies of natural product biosynthetic proteins.   Townsend, C A R01ES001670, R01ES001670 Chem Biol (1997 Oct) 9375250 Exiting the NIEHS site 1997 
Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid ...   Watanabe, C M; Wilson, D; Linz, J E; Townsend, C A R01ES001670, R01ES001670 Chem Biol (1996 Jun) 8807876 Exiting the NIEHS site 1996 
Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Exp ...   Silva, J C; Minto, R E; Barry 3rd, C E; Holland, K A; Townsend, C A R01ES001670, R01ES001670 J Biol Chem (1996 Jun 07) 8662689 Exiting the NIEHS site 1996 
Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis ...   McGuire, S M; Silva, J C; Casillas, E G; Townsend, C A R01ES001670, R01ES001670 Biochemistry (1996 Sep 3) 8784203 Exiting the NIEHS site 1996 
Sterigmatocystin production on complex and defined substrates.   Bennett, J W; Henderberg, A; Grossman, K R01ES001670, R01ES001670 Mycopathologia (1989 Jan) 2662007 Exiting the NIEHS site 1989 
Biosynthetic origin of aflatoxin G1: confirmation of sterigmatocystin and lack of confirmation of af ...   Henderberg, A; Bennett, J W; Lee, L S R01ES001670, R01ES001670 J Gen Microbiol (1988 Mar) 3141572 Exiting the NIEHS site 1988 
New perspectives on aflatoxin biosynthesis.   Bennett, J W; Christensen, S B R01ES001670, R01ES001670 Adv Appl Microbiol (1983) 6650265 Exiting the NIEHS site 1983 
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