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Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: ITERATIVE POLYKETIDE SYNTHASE FUNCTION, STRUCTURE AND PATHWAYS
PI: Townsend, Craig Arthur
Institution: Johns Hopkins University
Grant Number: R01ES001670

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 55 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES001670/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis.   Cohen, Douglas R; Townsend, Craig A R01ES001670 Nat Chem (2018 02) 29359752 Exiting the NIEHS site 2018 
Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis.   Cohen, Douglas R; Townsend, Craig A R01ES001670 Angew Chem Int Ed Engl (2018 05 14) 29512267 Exiting the NIEHS site 2018 
Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacety ...   Saraiva, Raúl G; Huitt-Roehl, Callie R; Tripathi, Abhai; Cheng, Yi-Qiang; Bosch, Jürgen; Townse ... R01ES001670 Sci Rep (2018 04 18) 29670144 Exiting the NIEHS site 2018 
Exploring Fungal Polyketide C-Methylation through Combinatorial Domain Swaps.   Storm, Philip A; Pal, Paramita; Huitt-Roehl, Callie R; Townsend, Craig A R01ES001670 ACS Chem Biol (2018 11 16) 30350943 Exiting the NIEHS site 2018 
Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to t ...   de Jonge, Ronnie; Ebert, Malaika K; Huitt-Roehl, Callie R; Pal, Paramita; Suttle, Jeffrey C; Sp ... R01ES001670 Proc Natl Acad Sci U S A (2018 06 12) 29844193 Exiting the NIEHS site 2018 
The architectures of iterative type I PKS and FAS.   Herbst, Dominik A; Townsend, Craig A; Maier, Timm R01ES001670 Nat Prod Rep (2018 10 17) 30137093 Exiting the NIEHS site 2018 
The structural organization of substrate loading in iterative polyketide synthases.   Herbst, Dominik A; Huitt-Roehl, Callie R; Jakob, Roman P; Kravetz, Jacob M; Storm, Philip A; Al ... R01ES001670 Nat Chem Biol (2018 05) 29610486 Exiting the NIEHS site 2018 
Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Pol ...   Storm, Philip A; Herbst, Dominik A; Maier, Timm; Townsend, Craig A R01ES001670 Cell Chem Biol (2017 Mar 16) 28238725 Exiting the NIEHS site 2017 
In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis ...   Storm, Philip A; Townsend, Craig A R01ES001670 Chem Commun (Camb) (2017 Dec 19) 29189834 Exiting the NIEHS site 2017 
Polyketide mimetics yield structural and mechanistic insights into product template domain function ...   Barajas, Jesus F; Shakya, Gaurav; Moreno, Gabriel; Rivera Jr, Heriberto; Jackson, David R; Topp ... R01ES001670 Proc Natl Acad Sci U S A (2017 05 23) 28484029 Exiting the NIEHS site 2017 
Molecular Characterization of the Cercosporin Biosynthetic Pathway in the Fungal Plant Pathogen Cerc ...   Newman, Adam G; Townsend, Craig A R01ES001670 J Am Chem Soc (2016 Mar 30) 26938470 Exiting the NIEHS site 2016 
Quenching of pH-Responsive Luminescence of a Benzoindolizine Sensor by an Ultrafast Hydrogen Shift.   Zhou, Jiawang; Outlaw, Victor K; Townsend, Craig A; Bragg, Arthur E R01ES001670 Chemistry (2016 Oct 17) 27549912 Exiting the NIEHS site 2016 
Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein ...   Barajas, Jesus F; Finzel, Kara; Valentic, Timothy R; Shakya, Gaurav; Gamarra, Nathan; Martinez, ... R01ES001670 Angew Chem Int Ed Engl (2016 10 10) 27653519 Exiting the NIEHS site 2016 
Unusual Blue-Shifted Acid-Responsive Photoluminescence Behavior in 6-Amino-8-cyanobenzo[1,2-b]indoli ...   Outlaw, Victor K; Zhou, Jiawang; Bragg, Arthur E; Townsend, Craig A R01ES001670 RSC Adv (2016 Jul 08) 28580137 Exiting the NIEHS site 2016 
New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1.   Conradt, David; Schätzle, Michael A; Haas, Julian; Townsend, Craig A; Müller, Michael R01ES001670 J Am Chem Soc (2015 Sep 02) 26266881 Exiting the NIEHS site 2015 
One-pot synthesis of highly substituted N-fused heteroaromatic bicycles from azole aldehydes.   Outlaw, Victor K; d'Andrea, Felipe B; Townsend, Craig A R01ES001670 Org Lett (2015 Apr 17) 25815402 Exiting the NIEHS site 2015 
Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase Pks ...   Huitt-Roehl, Callie R; Hill, Eric A; Adams, Martina M; Vagstad, Anna L; Li, Jesse W; Townsend, ... R01ES001670 ACS Chem Biol (2015 Jun 19) 25714897 Exiting the NIEHS site 2015 
A practical route to substituted 7-aminoindoles from pyrrole-3-carboxaldehydes.   Outlaw, Victor K; Townsend, Craig A R01ES001670 Org Lett (2014 Dec 19) 25479249 Exiting the NIEHS site 2014 
Aflatoxin and deconstruction of type I, iterative polyketide synthase function.   Townsend, Craig A R01ES001670 Nat Prod Rep (2014 Oct) 25079257 Exiting the NIEHS site 2014 
Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic underst ...   Newman, Adam G; Vagstad, Anna L; Storm, Philip A; Townsend, Craig A R01ES001670 J Am Chem Soc (2014 May 21) 24815013 Exiting the NIEHS site 2014 
Active site comparisons and catalytic mechanisms of the hot dog superfamily.   Labonte, Jason W; Townsend, Craig A R01ES001670 Chem Rev (2013 Mar 13) 23205964 Exiting the NIEHS site 2013 
Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed oct ...   Belecki, Katherine; Townsend, Craig A R01ES001670 J Am Chem Soc (2013 Sep 25) 24041368 Exiting the NIEHS site 2013 
Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming ...   Vagstad, Anna L; Newman, Adam G; Storm, Philip A; Belecki, Katherine; Crawford, Jason M; Townse ... R01ES001670 Angew Chem Int Ed Engl (2013 Feb 04) 23283670 Exiting the NIEHS site 2013 
Enzymology: Modular biosynthesis branches out.   Townsend, Craig A R01ES001670 Nature (2013 Oct 03) 24048474 Exiting the NIEHS site 2013 
Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase ...   Bruegger, Joel; Haushalter, Robert W; Haushalter, Bob; Vagstad, Anna L; Vagstad, Anna; Shakya, ... R01ES001670 Chem Biol (2013 Sep 19) 23993461 Exiting the NIEHS site 2013 
Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.   Newman, Adam G; Vagstad, Anna L; Belecki, Katherine; Scheerer, Jonathan R; Townsend, Craig A R01ES001670 Chem Commun (Camb) (2012 Dec 14) 23108075 Exiting the NIEHS site 2012 
Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melan ...   Vagstad, Anna L; Hill, Eric A; Labonte, Jason W; Townsend, Craig A R01ES001670 Chem Biol (2012 Dec 21) 23261597 Exiting the NIEHS site 2012 
Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, non ...   Foulke-Abel, Jennifer; Townsend, Craig A R01ES001670 Chembiochem (2012 Sep 03) 22807303 Exiting the NIEHS site 2012 
Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed oc ...   Belecki, Katherine; Townsend, Craig A R01ES001670 Angew Chem Int Ed Engl (2012 Nov 5) 23042574 Exiting the NIEHS site 2012 
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals stra ...   Vagstad, Anna L; Bumpus, Stefanie B; Belecki, Katherine; Kelleher, Neil L; Townsend, Craig A R01ES001670 J Am Chem Soc (2012 Apr 18) 22452347 Exiting the NIEHS site 2012 
Polyketide proofreading by an acyltransferase-like enzyme.   Jensen, Katja; Niederkrüger, Holger; Zimmermann, Katrin; Vagstad, Anna L; Moldenhauer, Jana; Br ... R01ES001670 Chem Biol (2012 Mar 23) 22444588 Exiting the NIEHS site 2012 
A "diels-alderase" at last.   Townsend, Craig A R01ES001670 Chembiochem (2011 Oct 17) 21796752 Exiting the NIEHS site 2011 
Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Asperg ...   Ehrlich, Kenneth C; Chang, Perng-Kuang; Scharfenstein Jr, Leslie L; Cary, Jeffrey W; Crawford, ... R01ES001670 FEMS Microbiol Lett (2010 Apr) 20158523 Exiting the NIEHS site 2010 
New insights into the formation of fungal aromatic polyketides.   Crawford, Jason M; Townsend, Craig A R01ES001670 Nat Rev Microbiol (2010 Dec) 21079635 Exiting the NIEHS site 2010 
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cy ...   Korman, Tyler Paz; Crawford, Jason M; Labonte, Jason W; Newman, Adam G; Wong, Justin; Townsend, ... R01ES001670 Proc Natl Acad Sci U S A (2010 Apr 06) 20332208 Exiting the NIEHS site 2010 
Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for t ...   Belecki, Katherine; Crawford, Jason M; Townsend, Craig A R01ES001670 J Am Chem Soc (2009 Sep 9) 19689130 Exiting the NIEHS site 2009 
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.   Crawford, Jason M; Korman, Tyler P; Labonte, Jason W; Vagstad, Anna L; Hill, Eric A; Kamari-Bid ... R01ES001670 Nature (2009 Oct 22) 19847268 Exiting the NIEHS site 2009 
Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases.   Crawford, Jason M; Vagstad, Anna L; Ehrlich, Kenneth C; Udwary, Daniel W; Townsend, Craig A R01ES001670 Chembiochem (2008 Jul 02) 18551496 Exiting the NIEHS site 2008 
Deconstruction of iterative multidomain polyketide synthase function.   Crawford, Jason M; Thomas, Paul M; Scheerer, Jonathan R; Vagstad, Anna L; Kelleher, Neil L; Tow ... R01ES001670 Science (2008 Apr 11) 18403714 Exiting the NIEHS site 2008 
Starter unit specificity directs genome mining of polyketide synthase pathways in fungi.   Crawford, Jason M; Vagstad, Anna L; Ehrlich, Kenneth C; Townsend, Craig A R01ES001670 Bioorg Chem (2008 Feb) 18215412 Exiting the NIEHS site 2008 
Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "st ...   Crawford, Jason M; Vagstad, Anna L; Whitworth, Karen P; Ehrlich, Kenneth C; Townsend, Craig A R01ES001670 Chembiochem (2008 May 05) 18338425 Exiting the NIEHS site 2008 
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I pol ...   Crawford, Jason M; Dancy, Blair C R; Hill, Eric A; Udwary, Daniel W; Townsend, Craig A R01ES001670 Proc Natl Acad Sci U S A (2006 Nov 7) 17071746 Exiting the NIEHS site 2006 
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yie ...   Henry, Kevin M; Townsend, Craig A R01ES001670 J Am Chem Soc (2005 Mar 23) 15771506 Exiting the NIEHS site 2005 
Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin.   Henry, Kevin M; Townsend, Craig A R01ES001670 J Am Chem Soc (2005 Mar 16) 15755146 Exiting the NIEHS site 2005 
A method for prediction of the locations of linker regions within large multifunctional proteins, an ...   Udwary, Daniel W; Merski, Matthew; Townsend, Craig A R01ES001670 J Mol Biol (2002 Oct 25) 12381311 Exiting the NIEHS site 2002 
Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex ...   Watanabe, Coran M H; Townsend, Craig A R01ES001670 Chem Biol (2002 Sep) 12323372 Exiting the NIEHS site 2002 
Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulan ...   Keller, N P; Watanabe, C M; Kelkar, H S; Adams, T H; Townsend, C A R01ES001670 Appl Environ Microbiol (2000 Jan) 10618248 Exiting the NIEHS site 2000 
Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus ...   Silva, J C; Townsend, C A R01ES001670 J Biol Chem (1997 Jan 10) 8995367 Exiting the NIEHS site 1997 
Structural studies of natural product biosynthetic proteins.   Townsend, C A R01ES001670 Chem Biol (1997 Oct) 9375250 Exiting the NIEHS site 1997 
Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid ...   Watanabe, C M; Wilson, D; Linz, J E; Townsend, C A R01ES001670 Chem Biol (1996 Jun) 8807876 Exiting the NIEHS site 1996 
Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Exp ...   Silva, J C; Minto, R E; Barry 3rd, C E; Holland, K A; Townsend, C A R01ES001670 J Biol Chem (1996 Jun 07) 8662689 Exiting the NIEHS site 1996 
Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis ...   McGuire, S M; Silva, J C; Casillas, E G; Townsend, C A R01ES001670 Biochemistry (1996 Sep 3) 8784203 Exiting the NIEHS site 1996 
Sterigmatocystin production on complex and defined substrates.   Bennett, J W; Henderberg, A; Grossman, K R01ES001670 Mycopathologia (1989 Jan) 2662007 Exiting the NIEHS site 1989 
Biosynthetic origin of aflatoxin G1: confirmation of sterigmatocystin and lack of confirmation of af ...   Henderberg, A; Bennett, J W; Lee, L S R01ES001670 J Gen Microbiol (1988 Mar) 3141572 Exiting the NIEHS site 1988 
New perspectives on aflatoxin biosynthesis.   Bennett, J W; Christensen, S B R01ES001670 Adv Appl Microbiol (1983) 6650265 Exiting the NIEHS site 1983 
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