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Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: HYPOXIA, DNA REPAIR, AND GENE SILENCING
PI: Glazer, Peter M
Institution: Yale University
Grant Number: R01ES005775

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 74 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES005775/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the ...   Lu, Yuhong; Liu, Yanfeng; Oeck, Sebastian; Zhang, Gary J; Schramm, Alexander; Glazer, Peter M R01ES005775 Cancer Res (2020 11 01) 32873635 Exiting the NIEHS site 2020 
Impact of hypoxia on DNA repair and genome integrity.   Kaplan, Alanna R; Glazer, Peter M R01ES005775 Mutagenesis (2020 02 13) 31282537 Exiting the NIEHS site 2020 
Oncometabolites suppress DNA repair by disrupting local chromatin signalling.   Sulkowski, Parker L; Oeck, Sebastian; Dow, Jonathan; Economos, Nicholas G; Mirfakhraie, Lily; L ... R01ES005775 Nature (2020 06) 32494005 Exiting the NIEHS site 2020 
Pharmacological methods to transcriptionally modulate double-strand break DNA repair.   Kaplan, Alanna R; Glazer, Peter M R01ES005775 Int Rev Cell Mol Biol (2020) 32475473 Exiting the NIEHS site 2020 
Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide.   Svoronos, Alexander A; Bahal, Raman; Pereira, Mohan C; Barrera, Francisco N; Deacon, John C; Bo ... R01ES005775 Mol Pharm (2020 02 03) 31855437 Exiting the NIEHS site 2020 
A parametric meta-analysis.   Yu, Chang; Zelterman, Daniel R01ES005775 Stat Med (2019 09 20) 31206759 Exiting the NIEHS site 2019 
A two-stage phase II clinical trial design with nested criteria for early stopping and efficacy.   DeVeaux, Michelle; Kane, Michael; Wei, Wei; Zelterman, Daniel R01ES005775, R01ES019179 Pharm Stat (2019 11) 31507079 Exiting the NIEHS site 2019 
Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51.   Kaplan, Alanna R; Gueble, Susan E; Liu, Yanfeng; Oeck, Sebastian; Kim, Hoon; Yun, Zhong; Glaze ... R01ES005775 Sci Transl Med (2019 05 15) 31092693 Exiting the NIEHS site 2019 
High-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation.   Oeck, Sebastian; Malewicz, Nathalie M; Krysztofiak, Adam; Turchick, Audrey; Jendrossek, Verena; ... R01ES005775 Sci Rep (2019 02 28) 30816253 Exiting the NIEHS site 2019 
Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment R ...   Wen, Zhiwei; Peng, Jufang; Tuttle, Paloma R; Ren, Yaou; Garcia, Carol; Debnath, Dipra; Rishi, ... R01ES005775, R01ES023569 Org Lett (2018 12 07) 30457873 Exiting the NIEHS site 2018 
Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and ...   Lu, Yuhong; Liu, Yanfeng; Oeck, Sebastian; Glazer, Peter M R01ES005775 Mol Cancer Res (2018 10) 29934325 Exiting the NIEHS site 2018 
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination ...   Sulkowski, Parker L; Sundaram, Ranjini K; Oeck, Sebastian; Corso, Christopher D; Liu, Yanfeng; ... R01ES005775 Nat Genet (2018 08) 30013182 Exiting the NIEHS site 2018 
PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF.   Sulkowski, Parker L; Scanlon, Susan E; Oeck, Sebastian; Glazer, Peter M R01ES005775 Mol Cancer Res (2018 08) 29739874 Exiting the NIEHS site 2018 
Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity ...   Scanlon, Susan E; Hegan, Denise C; Sulkowski, Parker L; Glazer, Peter M R01ES005775 Oncotarget (2018 Jan 12) 29435132 Exiting the NIEHS site 2018 
The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.   Kim, Hoon; Lin, Qun; Glazer, Peter M; Yun, Zhong R01ES005775 Breast Cancer Res (2018 03 06) 29510720 Exiting the NIEHS site 2018 
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and indu ...   Sulkowski, Parker L; Corso, Christopher D; Robinson, Nathaniel D; Scanlon, Susan E; Purshouse, ... R01ES005775 Sci Transl Med (2017 02 01) 28148839 Exiting the NIEHS site 2017 
A parametric model to estimate the proportion from true null using a distribution for p-values.   Yu, Chang; Zelterman, Daniel R01ES005775 Comput Stat Data Anal (2017 Oct) 28827889 Exiting the NIEHS site 2017 
Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy.   Gupta, Anisha; Quijano, Elias; Liu, Yanfeng; Bahal, Raman; Scanlon, Susan E; Song, Eric; Hsieh ... R01ES005775 Mol Ther Nucleic Acids (2017 Dec 15) 29246289 Exiting the NIEHS site 2017 
Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorig ...   Scanlon, Susan E; Scanlon, Christine D; Hegan, Denise C; Sulkowski, Parker L; Glazer, Peter M R01ES005775 Carcinogenesis (2017 06 01) 28472268 Exiting the NIEHS site 2017 
miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expre ...   Czochor, Jennifer R; Sulkowski, Parker; Glazer, Peter M R01ES005775 Mol Cancer Res (2016 Apr) 26850462 Exiting the NIEHS site 2016 
LKB1 preserves genome integrity by stimulating BRCA1 expression.   Gupta, Romi; Liu, Alex Y; Glazer, Peter M; Wajapeyee, Narendra R01ES005775 Nucleic Acids Res (2015 Jan) 25488815 Exiting the NIEHS site 2015 
Markov counting models for correlated binary responses.   Crawford, Forrest W; Zelterman, Daniel R01ES005775 Biostatistics (2015 Jul) 25792624 Exiting the NIEHS site 2015 
Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and ...   Colis, Laureen C; Hegan, Denise C; Kaneko, Miho; Glazer, Peter M; Herzon, Seth B R01ES005775 J Am Chem Soc (2015 May 6) 25849366 Exiting the NIEHS site 2015 
MicroRNA silencing for cancer therapy targeted to the tumour microenvironment.   Cheng, Christopher J; Bahal, Raman; Babar, Imran A; Pincus, Zachary; Barrera, Francisco; Liu, ... R01ES005775 Nature (2015 Feb 05) 25409146 Exiting the NIEHS site 2015 
Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment.   Scanlon, Susan E; Glazer, Peter M R01ES005775 DNA Repair (Amst) (2015 Aug) 25956861 Exiting the NIEHS site 2015 
Tumor suppressor p53 stole the AKT in hypoxia.   Yun, Zhong; Glazer, Peter M R01ES005775 J Clin Invest (2015 Jun) 25961449 Exiting the NIEHS site 2015 
Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.   Scanlon, Susan E; Glazer, Peter M R01ES005775 Mol Cancer Res (2014 Jul) 24688021 Exiting the NIEHS site 2014 
Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on t ...   Lu, Yuhong; Wajapeyee, Narendra; Turker, Mitchell S; Glazer, Peter M R01ES005775 Cell Rep (2014 Jul 24) 25043185 Exiting the NIEHS site 2014 
The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.   Colis, Laureen C; Woo, Christina M; Hegan, Denise C; Li, Zhenwu; Glazer, Peter M; Herzon, Seth ... R01ES005775 Nat Chem (2014 Jun) 24848236 Exiting the NIEHS site 2014 
Hypoxia and DNA repair.   Glazer, Peter M; Hegan, Denise C; Lu, Yuhong; Czochor, Jennifer; Scanlon, Susan E R01ES005775 Yale J Biol Med (2013 Dec 13) 24348208 Exiting the NIEHS site 2013 
Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter.   Lu, Yuhong; Chu, Adrian; Turker, Mitchell S; Glazer, Peter M R01ES005775 Mol Cell Biol (2011 Aug) 21670155 Exiting the NIEHS site 2011 
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells.   Babar, Imran A; Czochor, Jennifer; Steinmetz, Allison; Weidhaas, Joanne B; Glazer, Peter M; Sla ... R01ES005775 Cancer Biol Ther (2011 Nov 15) 22027557 Exiting the NIEHS site 2011 
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2 ...   Hegan, Denise Campisi; Lu, Yuhong; Stachelek, Gregory C; Crosby, Meredith E; Bindra, Ranjit S; ... R01ES005775 Proc Natl Acad Sci U S A (2010 Feb 02) 20133863 Exiting the NIEHS site 2010 
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRC ...   Stachelek, Gregory C; Dalal, Shibani; Donigan, Katherine A; Campisi Hegan, Denise; Sweasy, Joan ... R01ES005775 Cancer Res (2010 Jan 01) 20028873 Exiting the NIEHS site 2010 
Emerging roles of microRNAs in the molecular responses to hypoxia.   Crosby, Meredith E; Devlin, Cecilia M; Glazer, Peter M; Calin, George A; Ivan, Mircea R01ES005775 Curr Pharm Des (2009) 19925433 Exiting the NIEHS site 2009 
MicroRNA regulation of DNA repair gene expression in hypoxic stress.   Crosby, Meredith E; Kulshreshtha, Ritu; Ivan, Mircea; Glazer, Peter M R01ES005775 Cancer Res (2009 Feb 01) 19141645 Exiting the NIEHS site 2009 
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance a ...   Chan, Norman; Koritzinsky, Marianne; Zhao, Helen; Bindra, Ranjit; Glazer, Peter M; Powell, Sim ... R01ES005775 Cancer Res (2008 Jan 15) 18199558 Exiting the NIEHS site 2008 
Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max net ...   Bindra, Ranjit S; Glazer, Peter M R01ES005775 Cancer Lett (2007 Jul 8) 17275176 Exiting the NIEHS site 2007 
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia.   Bindra, R S; Glazer, P M R01ES005775 Oncogene (2007 Mar 29) 17001309 Exiting the NIEHS site 2007 
Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites.   Bindra, Ranjit S; Glazer, Peter M R01ES005775 Cancer Biol Ther (2006 Oct) 17106239 Exiting the NIEHS site 2006 
CHK2-dependent phosphorylation of BRCA1 in hypoxia.   Gibson, Shannon L; Bindra, Ranjit S; Glazer, Peter M R01ES005775 Radiat Res (2006 Oct) 17007555 Exiting the NIEHS site 2006 
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, ...   Hegan, Denise Campisi; Narayanan, Latha; Jirik, Frank R; Edelmann, Winfried; Liskay, R Michael; ... R01ES005775 Carcinogenesis (2006 Dec) 16728433 Exiting the NIEHS site 2006 
Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage toler ...   Gibson, Shannon L; Narayanan, Latha; Hegan, Denise Campisi; Buermeyer, Andrew B; Liskay, R Mich ... R01ES005775 Cancer Lett (2006 Dec 8) 16426742 Exiting the NIEHS site 2006 
Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells.   Meng, Alice X; Jalali, Farid; Cuddihy, Andrew; Chan, Norman; Bindra, Ranjit S; Glazer, Peter M ... R01ES005775 Radiother Oncol (2005 Aug) 16026872 Exiting the NIEHS site 2005 
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.   Bindra, Ranjit S; Gibson, Shannon L; Meng, Alice; Westermark, Ulrica; Jasin, Maria; Pierce, An ... R01ES005775 Cancer Res (2005 Dec 15) 16357170 Exiting the NIEHS site 2005 
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.   Gibson, Shannon L; Bindra, Ranjit S; Glazer, Peter M R01ES005775 Cancer Res (2005 Dec 1) 16322218 Exiting the NIEHS site 2005 
Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced throug ...   Jensen, Ryan; Glazer, Peter M R01ES005775 Proc Natl Acad Sci U S A (2004 Apr 20) 15069205 Exiting the NIEHS site 2004 
Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.   Bindra, Ranjit S; Schaffer, Paul J; Meng, Alice; Woo, Jennifer; Måseide, Kårstein; Roth, Matt ... R01ES005775 Mol Cell Biol (2004 Oct) 15367671 Exiting the NIEHS site 2004 
Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.   Mihaylova, Valia T; Bindra, Ranjit S; Yuan, Jianling; Campisi, Denise; Narayanan, Latha; Jensen ... R01ES005775 Mol Cell Biol (2003 May) 12697826 Exiting the NIEHS site 2003 
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiat ...   Peretz, S; Jensen, R; Baserga, R; Glazer, P M R01ES005775 Proc Natl Acad Sci U S A (2001 Feb 13) 11172010 Exiting the NIEHS site 2001 
Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice.   Xu, X S; Narayanan, L; Dunklee, B; Liskay, R M; Glazer, P M R01ES005775 Cancer Res (2001 May 1) 11325851 Exiting the NIEHS site 2001 
Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways.   Zeng, M; Narayanan, L; Xu, X S; Prolla, T A; Liskay, R M; Glazer, P M R01ES005775 Cancer Res (2000 Sep 1) 10987303 Exiting the NIEHS site 2000 
Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions an ...   Andrew, S E; Xu, X S; Baross-Francis, A; Narayanan, L; Milhausen, K; Liskay, R M; Jirik, F R; ... R01ES005775 Carcinogenesis (2000 Jul) 10874005 Exiting the NIEHS site 2000 
Different mutator phenotypes in Mlh1- versus Pms2-deficient mice.   Yao, X; Buermeyer, A B; Narayanan, L; Tran, D; Baker, S M; Prolla, T A; Glazer, P M; Liskay, ... R01ES005775 Proc Natl Acad Sci U S A (1999 Jun 08) 10359802 Exiting the NIEHS site 1999 
The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 c ...   Clairmont, C A; Narayanan, L; Sun, K W; Glazer, P M; Sweasy, J B R01ES005775 Proc Natl Acad Sci U S A (1999 Aug 17) 10449735 Exiting the NIEHS site 1999 
Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pm ...   Narayanan, L; Fritzell, J A; Baker, S M; Liskay, R M; Glazer, P M R01ES005775 Proc Natl Acad Sci U S A (1997 Apr 01) 9096356 Exiting the NIEHS site 1997 
Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local bre ...   Turner, B C; Haffty, B G; Narayanan, L; Yuan, J; Havre, P A; Gumbs, A A; Kaplan, L; Burgaud, ... R01ES005775 Cancer Res (1997 Aug 1) 9242428 Exiting the NIEHS site 1997 
Role of DNA mismatch repair in the cytotoxicity of ionizing radiation.   Fritzell, J A; Narayanan, L; Baker, S M; Bronner, C E; Andrew, S E; Prolla, T A; Bradley, A; ... R01ES005775 Cancer Res (1997 Nov 15) 9371516 Exiting the NIEHS site 1997 
Frequent spontaneous deletions at a shuttle vector locus in transgenic mice.   Leach, E G; Gunther, E J; Yeasky, T M; Gibson, L H; Yang-Feng, T L; Glazer, P M R01ES005775 Mutagenesis (1996 Jan) 8671715 Exiting the NIEHS site 1996 
Genetic instability induced by the tumor microenvironment.   Reynolds, T Y; Rockwell, S; Glazer, P M R01ES005775 Cancer Res (1996 Dec 15) 8971187 Exiting the NIEHS site 1996 
Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequenc ...   Raha, M; Wang, G; Seidman, M M; Glazer, P M R01ES005775 Proc Natl Acad Sci U S A (1996 Apr 02) 8610147 Exiting the NIEHS site 1996 
Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair.   Wang, G; Seidman, M M; Glazer, P M R01ES005775 Science (1996 Feb 09) 8628995 Exiting the NIEHS site 1996 
Recombination induced by triple-helix-targeted DNA damage in mammalian cells.   Faruqi, A F; Seidman, M M; Segal, D J; Carroll, D; Glazer, P M R01ES005775 Mol Cell Biol (1996 Dec) 8943337 Exiting the NIEHS site 1996 
Targeted mutagenesis mediated by the triple helix formation.   Glazer, P M; Wang, G; Havre, P A; Gunther, E J R01ES005775 Methods Mol Biol (1996) 8849999 Exiting the NIEHS site 1996 
Tissue specificity of spontaneous point mutations in lambda supF transgenic mice.   Leach, E G; Narayanan, L; Havre, P A; Gunther, E J; Yeasky, T M; Glazer, P M R01ES005775 Environ Mol Mutagen (1996) 8991078 Exiting the NIEHS site 1996 
Altered repair of targeted psoralen photoadducts in the context of an oligonucleotide-mediated tripl ...   Wang, G; Glazer, P M R01ES005775 J Biol Chem (1995 Sep 22) 7673252 Exiting the NIEHS site 1995 
Frequent T:A-->G:C transversions in X-irradiated mouse cells.   Yuan, J; Yeasky, T M; Rhee, M C; Glazer, P M R01ES005775 Carcinogenesis (1995 Jan) 7834808 Exiting the NIEHS site 1995 
Induction of p53 in mouse cells decreases mutagenesis by UV radiation.   Yuan, J; Yeasky, T M; Havre, P A; Glazer, P M R01ES005775 Carcinogenesis (1995 Oct) 7586125 Exiting the NIEHS site 1995 
Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: mutations ...   Gunther, E J; Yeasky, T M; Gasparro, F P; Glazer, P M R01ES005775 Cancer Res (1995 Mar 15) 7882323 Exiting the NIEHS site 1995 
Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation.   Wang, G; Levy, D D; Seidman, M M; Glazer, P M R01ES005775 Mol Cell Biol (1995 Mar) 7862165 Exiting the NIEHS site 1995 
Site-specific targeting of psoralen photoadducts with a triple helix-forming oligonucleotide: charac ...   Gasparro, F P; Havre, P A; Olack, G A; Gunther, E J; Glazer, P M R01ES005775 Nucleic Acids Res (1994 Jul 25) 8052539 Exiting the NIEHS site 1994 
High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA usin ...   Gunther, E J; Murray, N E; Glazer, P M R01ES005775 Nucleic Acids Res (1993 Aug 11) 8396240 Exiting the NIEHS site 1993 
Targeted mutagenesis of DNA using triple helix-forming oligonucleotides linked to psoralen.   Havre, P A; Gunther, E J; Gasparro, F P; Glazer, P M R01ES005775 Proc Natl Acad Sci U S A (1993 Aug 15) 8356097 Exiting the NIEHS site 1993 
Targeted mutagenesis of simian virus 40 DNA mediated by a triple helix-forming oligonucleotide.   Havre, P A; Glazer, P M R01ES005775 J Virol (1993 Dec) 8230456 Exiting the NIEHS site 1993 
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