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Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: BIOACTIVATION OF HALOGENATED HYDROCARBONS
PI: Guengerich, F Peter
Institution: Vanderbilt University
Grant Number: R01ES010546

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 75 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES010546/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation.   Ahmed, Nabeel; Chakrabarty, Anindita; Guengerich, F Peter; Chowdhury, Goutam R01ES010546 Chem Res Toxicol (2020 10 19) 32894672 Exiting the NIEHS site 2020 
Human DNA polymerase η has reverse transcriptase activity in cellular environments.   Su, Yan; Ghodke, Pratibha P; Egli, Martin; Li, Lin; Wang, Yinsheng; Guengerich, F Peter R01ES010546, R01ES025121, R01ES026955, R01ES029357 J Biol Chem (2019 04 12) 30842261 Exiting the NIEHS site 2019 
Synthesis and Characterization of Site-Specific O6 -Alkylguanine DNA-Alkyl Transferase-Oligonucleoti ...   Ghodke, Pratibha P; Albertolle, Matthew E; Johnson, Kevin M; Guengerich, F Peter R01ES010546, R01ES026955, T32ES007028 Curr Protoc Nucleic Acid Chem (2019 03) 30657645 Exiting the NIEHS site 2019 
The abundant DNA adduct N7-methyl deoxyguanosine contributes to miscoding during replication by huma ...   Njuma, Olive J; Su, Yan; Guengerich, F Peter R01ES010546, T32ES007028 J Biol Chem (2019 06 28) 31101656 Exiting the NIEHS site 2019 
Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Tr ...   Sedgeman, Carl A; Su, Yan; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2017 05 15) 28395138 Exiting the NIEHS site 2017 
Human DNA polymerase η accommodates RNA for strand extension.   Su, Yan; Egli, Martin; Guengerich, F Peter R01ES010546, R01ES026955 J Biol Chem (2017 11 03) 28972162 Exiting the NIEHS site 2017 
Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Sy ...   Wickramaratne, Susith; Ji, Shaofei; Mukherjee, Shivam; Su, Yan; Pence, Matthew G; Lior-Hoffmann ... R01ES010546, R01ES023350, R01ES025987 J Biol Chem (2016 Nov 04) 27621316 Exiting the NIEHS site 2016 
Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of H ...   Yeom, Mina; Kim, In-Hyeok; Kim, Jae-Kwon; Kang, KyeongJin; Eoff, Robert L; Guengerich, F Peter ... R01ES010546 Chem Res Toxicol (2016 Mar 21) 26914252 Exiting the NIEHS site 2016 
Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA ...   Xue, Qizhen; Zhong, Mengyu; Liu, Binyan; Tang, Yong; Wei, Zeliang; Guengerich, F Peter; Zhang, ... R01ES010546 Biochimie (2016 Feb) 26700143 Exiting the NIEHS site 2016 
Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.   Choi, Jeong-Yun; Patra, Amritaj; Yeom, Mina; Lee, Young-Sam; Zhang, Qianqian; Egli, Martin; Gu ... R01ES010546 J Biol Chem (2016 Sep 30) 27555320 Exiting the NIEHS site 2016 
Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.   O'Flaherty, D K; Patra, A; Su, Y; Guengerich, F P; Egli, M; Wilds, C J R01ES010546 Chem Sci (2016 Aug 01) 27574558 Exiting the NIEHS site 2016 
Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η.   Su, Yan; Egli, Martin; Guengerich, F Peter R01ES010546 J Biol Chem (2016 Feb 19) 26740629 Exiting the NIEHS site 2016 
Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Huma ...   Patra, Amitraj; Zhang, Qianqian; Guengerich, F Peter; Egli, Martin R01ES010546 J Biol Chem (2016 Nov 11) 27694439 Exiting the NIEHS site 2016 
Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.   Liu, Binyan; Xue, Qizhen; Tang, Yong; Cao, Jia; Guengerich, F Peter; Zhang, Huidong R01ES010546 Mutat Res Rev Mutat Res (2016 Apr-Jun) 27234563 Exiting the NIEHS site 2016 
Metals in Biology 2016: Molecular Basis of Selection of Metals by Enzymes.   Guengerich, F Peter R01ES010546 J Biol Chem (2016 Sep 30) 27462079 Exiting the NIEHS site 2016 
Pre-Steady-State Kinetic Analysis of Single-Nucleotide Incorporation by DNA Polymerases.   Su, Yan; Peter Guengerich, F R01ES010546 Curr Protoc Nucleic Acid Chem (2016 06 01) 27248785 Exiting the NIEHS site 2016 
Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.   Kim, Jae-Kwon; Yeom, Mina; Hong, Jin-Kyung; Song, Insil; Lee, Young-Sam; Guengerich, F Peter; ... R01ES010546 Chem Res Toxicol (2016 10 17) 27603496 Exiting the NIEHS site 2016 
Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Hu ...   Patra, Amritraj; Su, Yan; Zhang, Qianqian; Johnson, Kevin M; Guengerich, F Peter; Egli, Martin R01ES010546 J Biol Chem (2016 Jul 01) 27226627 Exiting the NIEHS site 2016 
Carcinogenesis of urethane: simulation versus experiment.   Lajovic, Andrej; Nagy, Leslie D; Guengerich, F Peter; Bren, Urban R01ES010546 Chem Res Toxicol (2015 Apr 20) 25642734 Exiting the NIEHS site 2015 
Characterization of thioether-linked protein adducts of DNA using a Raney-Ni-mediated desulfurizatio ...   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Curr Protoc Nucleic Acid Chem (2015 Mar 09) 25754888 Exiting the NIEHS site 2015 
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins.   Zdżalik, Daria; Domańska, Anna; Prorok, Paulina; Kosicki, Konrad; van den Born, Erwin; Falnes, ... R01ES010546 DNA Repair (Amst) (2015 Jun) 25797601 Exiting the NIEHS site 2015 
Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in ...   Chang, Shiou-chi; Fedeles, Bogdan I; Wu, Jie; Delaney, James C; Li, Deyu; Zhao, Linlin; Christ ... P30ES002109, R01ES010546, T32ES007020 Nucleic Acids Res (2015 Jun 23) 25837992 Exiting the NIEHS site 2015 
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic ...   Rendic, Slobodan; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2015 Jan 20) 25485457 Exiting the NIEHS site 2015 
Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thali ...   Chowdhury, Goutam; Shibata, Norio; Yamazaki, Hiroshi; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2014 Jan 21) 24350712 Exiting the NIEHS site 2014 
Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylgu ...   Chowdhury, Goutam; Cho, Sung-Hee; Pegg, Anthony E; Guengerich, F Peter R01ES010546 Angew Chem Int Ed Engl (2013 Dec 2) 24130045 Exiting the NIEHS site 2013 
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutage ...   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2013 Nov 18) 24191644 Exiting the NIEHS site 2013 
Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydrox ...   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2013 Jun 17) 23701509 Exiting the NIEHS site 2013 
Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine.   Maddukuri, Leena; Shuck, Sarah C; Eoff, Robert L; Zhao, Linlin; Rizzo, Carmelo J; Guengerich, ... R01ES010546, T32ES007028 Biochemistry (2013 Dec 3) 24171480 Exiting the NIEHS site 2013 
Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases.   Zhao, Linlin; Pence, Matthew G; Christov, Plamen P; Wawrzak, Zdzislaw; Choi, Jeong-Yun; Rizzo, ... R01ES010546, T32ES007028 J Biol Chem (2012 Oct 12) 22910910 Exiting the NIEHS site 2012 
Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo.   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Mar 19) 22181695 Exiting the NIEHS site 2012 
Contributions of human enzymes in carcinogen metabolism.   Rendic, Slobodan; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Jul 16) 22531028 Exiting the NIEHS site 2012 
Introduction: use of radioactive compounds in drug discovery and development.   Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Mar 19) 22324508 Exiting the NIEHS site 2012 
Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its m ...   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Jul 16) 22670845 Exiting the NIEHS site 2012 
Replication of N2,3-ethenoguanine by DNA polymerases.   Zhao, Linlin; Christov, Plamen P; Kozekov, Ivan D; Pence, Matthew G; Pallan, Pradeep S; Rizzo, ... R01ES010546, T32ES007028 Angew Chem Int Ed Engl (2012 May 29) 22488769 Exiting the NIEHS site 2012 
1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched wi ...   Shanmugam, Ganesh; Kozekov, Ivan D; Guengerich, F Peter; Rizzo, Carmelo J; Stone, Michael P R01ES010546 Chem Res Toxicol (2011 Jul 18) 21675798 Exiting the NIEHS site 2011 
Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products.   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Curr Protoc Nucleic Acid Chem (2011 Dec) 22147421 Exiting the NIEHS site 2011 
Mechanisms of drug toxicity and relevance to pharmaceutical development.   Guengerich, F Peter R01ES010546 Drug Metab Pharmacokinet (2011) 20978361 Exiting the NIEHS site 2011 
Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and format ...   Chowdhury, Goutam; Murayama, Norie; Okada, Yusuke; Uno, Yasuhiro; Shimizu, Makiko; Shibata, No ... R01ES010546 Chem Res Toxicol (2010 Jun 21) 20443640 Exiting the NIEHS site 2010 
Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage.   Eoff, Robert L; Choi, Jeong-Yun; Guengerich, F Peter R01ES010546 J Nucleic Acids (2010 Sep 26) 20936119 Exiting the NIEHS site 2010 
Mutagenicity of a glutathione conjugate of butadiene diepoxide.   Cho, Sung-Hee; Loecken, Elisabeth M; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2010 Oct 18) 20879737 Exiting the NIEHS site 2010 
Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and eff ...   Brown, Kyle L; Bren, Urban; Stone, Michael P; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2009 May) 19301826 Exiting the NIEHS site 2009 
Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.   Knutson, Charles G; Rubinson, Emily H; Akingbade, Dapo; Anderson, Carolyn S; Stec, Donald F; Pe ... R01ES010546, T32ES007028 Biochemistry (2009 Feb 3) 19132922 Exiting the NIEHS site 2009 
Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA f ...   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2009 Jul) 19496605 Exiting the NIEHS site 2009 
The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced ...   Loecken, Elisabeth M; Dasari, Surendra; Hill, Salisha; Tabb, David L; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2009 Jun) 19364102 Exiting the NIEHS site 2009 
Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrome ...   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Angew Chem Int Ed Engl (2008) 18022988 Exiting the NIEHS site 2008 
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehy ...   Bodreddigari, Sridevi; Jones, Laundette Knight; Egner, Patricia A; Groopman, John D; Sutter, Ca ... R01ES010546, T32ES007141 Chem Res Toxicol (2008 May) 18416522 Exiting the NIEHS site 2008 
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produ ...   Loecken, Elisabeth M; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2008 Feb) 18163542 Exiting the NIEHS site 2008 
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.   Fang, Qingming; Noronha, Anne M; Murphy, Sebastian P; Wilds, Christopher J; Tubbs, Julie L; Tai ... R01ES010546 Biochemistry (2008 Oct 14) 18803403 Exiting the NIEHS site 2008 
Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, ...   Watanabe, Kengo; Liberman, Rosa G; Skipper, Paul L; Tannenbaum, Steven R; Guengerich, F Peter P30ES002109, R01ES010546 Chem Res Toxicol (2007 Nov) 17907789 Exiting the NIEHS site 2007 
Applying mechanisms of chemical toxicity to predict drug safety.   Guengerich, F Peter; MacDonald, James S R01ES010546 Chem Res Toxicol (2007 Mar) 17302443 Exiting the NIEHS site 2007 
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its abi ...   Liu, Liping; Watanabe, Kengo; Fang, Qingming; Williams, Kevin M; Guengerich, F Peter; Pegg, An ... R01ES010546, T32ES007028 Chem Res Toxicol (2007 Jan) 17226938 Exiting the NIEHS site 2007 
Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations.   Bren, Urban; Guengerich, F Peter; Mavri, Janez R01ES010546 Chem Res Toxicol (2007 Aug) 17630712 Exiting the NIEHS site 2007 
Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and gu ...   Bren, Urban; Zupan, Mateja; Guengerich, F Peter; Mavri, Janez R01ES010546 J Org Chem (2006 May 26) 16709046 Exiting the NIEHS site 2006 
Cytochrome P450s and other enzymes in drug metabolism and toxicity.   Guengerich, F Peter R01ES010546 AAPS J (2006) 16584116 Exiting the NIEHS site 2006 
Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of d ...   Watanabe, Kengo; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2006 Aug) 16918250 Exiting the NIEHS site 2006 
Generation of reactive intermediates.   Guengerich, F Peter R01ES010546 J Biochem Mol Toxicol (2005) 15977199 Exiting the NIEHS site 2005 
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase ...   Zang, Hong; Fang, Qingming; Pegg, Anthony E; Guengerich, F Peter R01ES010546 J Biol Chem (2005 Sep 02) 16000301 Exiting the NIEHS site 2005 
Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophil ...   Guengerich, F Peter R01ES010546 Arch Biochem Biophys (2005 Jan 15) 15581593 Exiting the NIEHS site 2005 
Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferas ...   Valadez, J Gerardo; Liu, Liping; Loktionova, Natalia A; Pegg, Anthony E; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2004 Jul) 15257623 Exiting the NIEHS site 2004 
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alky ...   Liu, Liping; Hachey, David L; Valadez, Gerardo; Williams, Kevin M; Guengerich, F Peter; Loktion ... R01ES010546, T32ES007028 J Biol Chem (2004 Feb 06) 14645247 Exiting the NIEHS site 2004 
Cytochrome P450: what have we learned and what are the future issues?   Guengerich, F Peter R01ES010546 Drug Metab Rev (2004 May) 15237850 Exiting the NIEHS site 2004 
Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutat ...   Marsch, Glenn A; Botta, Sisir; Martin, Martha V; McCormick, W Andrew; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2004 Jan) 14727918 Exiting the NIEHS site 2004 
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromom ...   Liu, Liping; Williams, Kevin M; Guengerich, F Peter; Pegg, Anthony E R01ES010546, T32ES007028 Chem Res Toxicol (2004 Jun) 15206895 Exiting the NIEHS site 2004 
S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair ra ...   Valadez, J Gerardo; Guengerich, F Peter R01ES010546 J Biol Chem (2004 Apr 02) 14715658 Exiting the NIEHS site 2004 
Activation of dihaloalkanes by thiol-dependent mechanisms.   Guengerich, F Peter R01ES010546 J Biochem Mol Biol (2003 Jan 31) 12542971 Exiting the NIEHS site 2003 
Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione tra ...   Guengerich, F Peter; McCormick, W Andrew; Wheeler, James B R01ES010546 Chem Res Toxicol (2003 Nov) 14615977 Exiting the NIEHS site 2003 
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methy ...   Woodside, Adrienne M; Guengerich, F Peter R01ES010546, T32ES007028 Biochemistry (2002 Jan 22) 11790127 Exiting the NIEHS site 2002 
Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide.   Yoshioka, Tadao; Krauser, Joel A; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2002 Nov) 12437332 Exiting the NIEHS site 2002 
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive po ...   Woodside, Adrienne M; Guengerich, F Peter R01ES010546, T32ES007028 Biochemistry (2002 Jan 22) 11790128 Exiting the NIEHS site 2002 
Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase ...   Liu, Liping; Pegg, Anthony E; Williams, Kevin M; Guengerich, F Peter R01ES010546, T32ES007028 J Biol Chem (2002 Oct 04) 12151404 Exiting the NIEHS site 2002 
Reaction of aflatoxin B(1) oxidation products with lysine.   Guengerich, F Peter; Arneson, Kyle O; Williams, Kevin M; Deng, Zhengwu; Harris, Thomas M R01ES010546, T32ES007028 Chem Res Toxicol (2002 Jun) 12067245 Exiting the NIEHS site 2002 
Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine.   Guengerich, F Peter; Voehler, Markus; Williams, Kevin M; Deng, Zhengwu; Harris, Thomas M R01ES010546, T32ES007028 Chem Res Toxicol (2002 Jun) 12067246 Exiting the NIEHS site 2002 
Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine.   Yoshioka, Tadao; Krauser, Joel A; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2002 Aug) 12184794 Exiting the NIEHS site 2002 
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalometh ...   Wheeler, J B; Stourman, N V; Thier, R; Dommermuth, A; Vuilleumier, S; Rose, J A; Armstrong, R ... R01ES010546 Chem Res Toxicol (2001 Aug) 11511186 Exiting the NIEHS site 2001 
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal di ...   Wheeler, J B; Stourman, N V; Armstrong, R N; Guengerich, F P R01ES010546 Chem Res Toxicol (2001 Aug) 11511185 Exiting the NIEHS site 2001 
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