| Project Title: | BIOACTIVATION OF HALOGENATED HYDROCARBONS |
|---|---|
| PI: | Guengerich, F Peter |
| Institution: | Vanderbilt University |
| Grant Number: | R01ES010546 |
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation. | Ahmed, Nabeel; Chakrabarty, Anindita; Guengerich, F Peter; Chowdhury, Goutam | R01ES010546 | Chem Res Toxicol (2020 10 19) |
32894672
|
2020 |
| Human DNA polymerase η has reverse transcriptase activity in cellular environments. | Su, Yan; Ghodke, Pratibha P; Egli, Martin; Li, Lin; Wang, Yinsheng; Guengerich, F Peter | R01ES010546, R01ES025121, R01ES026955, R01ES029357 | J Biol Chem (2019 04 12) |
30842261
|
2019 |
| Synthesis and Characterization of Site-Specific O6 -Alkylguanine DNA-Alkyl Transferase-Oligonucleoti ... | Ghodke, Pratibha P; Albertolle, Matthew E; Johnson, Kevin M; Guengerich, F Peter | R01ES010546, R01ES026955, T32ES007028 | Curr Protoc Nucleic Acid Chem (2019 03) |
30657645
|
2019 |
| The abundant DNA adduct N7-methyl deoxyguanosine contributes to miscoding during replication by huma ... | Njuma, Olive J; Su, Yan; Guengerich, F Peter | R01ES010546, T32ES007028 | J Biol Chem (2019 06 28) |
31101656
|
2019 |
| Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Tr ... | Sedgeman, Carl A; Su, Yan; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2017 05 15) |
28395138
|
2017 |
| Human DNA polymerase η accommodates RNA for strand extension. | Su, Yan; Egli, Martin; Guengerich, F Peter | R01ES010546, R01ES026955 | J Biol Chem (2017 11 03) |
28972162
|
2017 |
| Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Sy ... | Wickramaratne, Susith; Ji, Shaofei; Mukherjee, Shivam; Su, Yan; Pence, Matthew G; Lior-Hoffmann ... | R01ES010546, R01ES023350, R01ES025987 | J Biol Chem (2016 Nov 04) |
27621316
|
2016 |
| Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of H ... | Yeom, Mina; Kim, In-Hyeok; Kim, Jae-Kwon; Kang, KyeongJin; Eoff, Robert L; Guengerich, F Peter ... | R01ES010546 | Chem Res Toxicol (2016 Mar 21) |
26914252
|
2016 |
| Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA ... | Xue, Qizhen; Zhong, Mengyu; Liu, Binyan; Tang, Yong; Wei, Zeliang; Guengerich, F Peter; Zhang, ... | R01ES010546 | Biochimie (2016 Feb) |
26700143
|
2016 |
| Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι. | Choi, Jeong-Yun; Patra, Amritaj; Yeom, Mina; Lee, Young-Sam; Zhang, Qianqian; Egli, Martin; Gu ... | R01ES010546 | J Biol Chem (2016 Sep 30) |
27555320
|
2016 |
| Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η. | O'Flaherty, D K; Patra, A; Su, Y; Guengerich, F P; Egli, M; Wilds, C J | R01ES010546 | Chem Sci (2016 Aug 01) |
27574558
|
2016 |
| Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η. | Su, Yan; Egli, Martin; Guengerich, F Peter | R01ES010546 | J Biol Chem (2016 Feb 19) |
26740629
|
2016 |
| Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Huma ... | Patra, Amitraj; Zhang, Qianqian; Guengerich, F Peter; Egli, Martin | R01ES010546 | J Biol Chem (2016 Nov 11) |
27694439
|
2016 |
| Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. | Liu, Binyan; Xue, Qizhen; Tang, Yong; Cao, Jia; Guengerich, F Peter; Zhang, Huidong | R01ES010546 | Mutat Res Rev Mutat Res (2016 Apr-Jun) |
27234563
|
2016 |
| Metals in Biology 2016: Molecular Basis of Selection of Metals by Enzymes. | Guengerich, F Peter | R01ES010546 | J Biol Chem (2016 Sep 30) |
27462079
|
2016 |
| Pre-Steady-State Kinetic Analysis of Single-Nucleotide Incorporation by DNA Polymerases. | Su, Yan; Peter Guengerich, F | R01ES010546 | Curr Protoc Nucleic Acid Chem (2016 06 01) |
27248785
|
2016 |
| Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ. | Kim, Jae-Kwon; Yeom, Mina; Hong, Jin-Kyung; Song, Insil; Lee, Young-Sam; Guengerich, F Peter; ... | R01ES010546 | Chem Res Toxicol (2016 10 17) |
27603496
|
2016 |
| Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Hu ... | Patra, Amritraj; Su, Yan; Zhang, Qianqian; Johnson, Kevin M; Guengerich, F Peter; Egli, Martin | R01ES010546 | J Biol Chem (2016 Jul 01) |
27226627
|
2016 |
| Carcinogenesis of urethane: simulation versus experiment. | Lajovic, Andrej; Nagy, Leslie D; Guengerich, F Peter; Bren, Urban | R01ES010546 | Chem Res Toxicol (2015 Apr 20) |
25642734
|
2015 |
| Characterization of thioether-linked protein adducts of DNA using a Raney-Ni-mediated desulfurizatio ... | Chowdhury, Goutam; Guengerich, F Peter | R01ES010546 | Curr Protoc Nucleic Acid Chem (2015 Mar 09) |
25754888
|
2015 |
| Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. | Zdżalik, Daria; Domańska, Anna; Prorok, Paulina; Kosicki, Konrad; van den Born, Erwin; Falnes, ... | R01ES010546 | DNA Repair (Amst) (2015 Jun) |
25797601
|
2015 |
| Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in ... | Chang, Shiou-chi; Fedeles, Bogdan I; Wu, Jie; Delaney, James C; Li, Deyu; Zhao, Linlin; Christ ... | P30ES002109, R01ES010546, T32ES007020 | Nucleic Acids Res (2015 Jun 23) |
25837992
|
2015 |
| Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic ... | Rendic, Slobodan; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2015 Jan 20) |
25485457
|
2015 |
| Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thali ... | Chowdhury, Goutam; Shibata, Norio; Yamazaki, Hiroshi; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2014 Jan 21) |
24350712
|
2014 |
| Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylgu ... | Chowdhury, Goutam; Cho, Sung-Hee; Pegg, Anthony E; Guengerich, F Peter | R01ES010546 | Angew Chem Int Ed Engl (2013 Dec 2) |
24130045
|
2013 |
| In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutage ... | Cho, Sung-Hee; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2013 Nov 18) |
24191644
|
2013 |
| Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydrox ... | Cho, Sung-Hee; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2013 Jun 17) |
23701509
|
2013 |
| Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. | Maddukuri, Leena; Shuck, Sarah C; Eoff, Robert L; Zhao, Linlin; Rizzo, Carmelo J; Guengerich, ... | R01ES010546, T32ES007028 | Biochemistry (2013 Dec 3) |
24171480
|
2013 |
| Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases. | Zhao, Linlin; Pence, Matthew G; Christov, Plamen P; Wawrzak, Zdzislaw; Choi, Jeong-Yun; Rizzo, ... | R01ES010546, T32ES007028 | J Biol Chem (2012 Oct 12) |
22910910
|
2012 |
| Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo. | Cho, Sung-Hee; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2012 Mar 19) |
22181695
|
2012 |
| Contributions of human enzymes in carcinogen metabolism. | Rendic, Slobodan; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2012 Jul 16) |
22531028
|
2012 |
| Introduction: use of radioactive compounds in drug discovery and development. | Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2012 Mar 19) |
22324508
|
2012 |
| Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its m ... | Cho, Sung-Hee; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2012 Jul 16) |
22670845
|
2012 |
| Replication of N2,3-ethenoguanine by DNA polymerases. | Zhao, Linlin; Christov, Plamen P; Kozekov, Ivan D; Pence, Matthew G; Pallan, Pradeep S; Rizzo, ... | R01ES010546, T32ES007028 | Angew Chem Int Ed Engl (2012 May 29) |
22488769
|
2012 |
| 1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched wi ... | Shanmugam, Ganesh; Kozekov, Ivan D; Guengerich, F Peter; Rizzo, Carmelo J; Stone, Michael P | R01ES010546 | Chem Res Toxicol (2011 Jul 18) |
21675798
|
2011 |
| Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products. | Chowdhury, Goutam; Guengerich, F Peter | R01ES010546 | Curr Protoc Nucleic Acid Chem (2011 Dec) |
22147421
|
2011 |
| Mechanisms of drug toxicity and relevance to pharmaceutical development. | Guengerich, F Peter | R01ES010546 | Drug Metab Pharmacokinet (2011) |
20978361
|
2011 |
| Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and format ... | Chowdhury, Goutam; Murayama, Norie; Okada, Yusuke; Uno, Yasuhiro; Shimizu, Makiko; Shibata, No ... | R01ES010546 | Chem Res Toxicol (2010 Jun 21) |
20443640
|
2010 |
| Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage. | Eoff, Robert L; Choi, Jeong-Yun; Guengerich, F Peter | R01ES010546 | J Nucleic Acids (2010 Sep 26) |
20936119
|
2010 |
| Mutagenicity of a glutathione conjugate of butadiene diepoxide. | Cho, Sung-Hee; Loecken, Elisabeth M; Guengerich, F Peter | R01ES010546, T32ES007028 | Chem Res Toxicol (2010 Oct 18) |
20879737
|
2010 |
| Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and eff ... | Brown, Kyle L; Bren, Urban; Stone, Michael P; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2009 May) |
19301826
|
2009 |
| Oxidation and glycolytic cleavage of etheno and propano DNA base adducts. | Knutson, Charles G; Rubinson, Emily H; Akingbade, Dapo; Anderson, Carolyn S; Stec, Donald F; Pe ... | R01ES010546, T32ES007028 | Biochemistry (2009 Feb 3) |
19132922
|
2009 |
| Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA f ... | Chowdhury, Goutam; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2009 Jul) |
19496605
|
2009 |
| The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced ... | Loecken, Elisabeth M; Dasari, Surendra; Hill, Salisha; Tabb, David L; Guengerich, F Peter | R01ES010546, T32ES007028 | Chem Res Toxicol (2009 Jun) |
19364102
|
2009 |
| Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrome ... | Chowdhury, Goutam; Guengerich, F Peter | R01ES010546 | Angew Chem Int Ed Engl (2008) |
18022988
|
2008 |
| Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehy ... | Bodreddigari, Sridevi; Jones, Laundette Knight; Egner, Patricia A; Groopman, John D; Sutter, Ca ... | R01ES010546, T32ES007141 | Chem Res Toxicol (2008 May) |
18416522
|
2008 |
| Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produ ... | Loecken, Elisabeth M; Guengerich, F Peter | R01ES010546, T32ES007028 | Chem Res Toxicol (2008 Feb) |
18163542
|
2008 |
| Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. | Fang, Qingming; Noronha, Anne M; Murphy, Sebastian P; Wilds, Christopher J; Tubbs, Julie L; Tai ... | R01ES010546 | Biochemistry (2008 Oct 14) |
18803403
|
2008 |
| Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, ... | Watanabe, Kengo; Liberman, Rosa G; Skipper, Paul L; Tannenbaum, Steven R; Guengerich, F Peter | P30ES002109, R01ES010546 | Chem Res Toxicol (2007 Nov) |
17907789
|
2007 |
| Applying mechanisms of chemical toxicity to predict drug safety. | Guengerich, F Peter; MacDonald, James S | R01ES010546 | Chem Res Toxicol (2007 Mar) |
17302443
|
2007 |
| Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its abi ... | Liu, Liping; Watanabe, Kengo; Fang, Qingming; Williams, Kevin M; Guengerich, F Peter; Pegg, An ... | R01ES010546, T32ES007028 | Chem Res Toxicol (2007 Jan) |
17226938
|
2007 |
| Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations. | Bren, Urban; Guengerich, F Peter; Mavri, Janez | R01ES010546 | Chem Res Toxicol (2007 Aug) |
17630712
|
2007 |
| Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and gu ... | Bren, Urban; Zupan, Mateja; Guengerich, F Peter; Mavri, Janez | R01ES010546 | J Org Chem (2006 May 26) |
16709046
|
2006 |
| Cytochrome P450s and other enzymes in drug metabolism and toxicity. | Guengerich, F Peter | R01ES010546 | AAPS J (2006) |
16584116
|
2006 |
| Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of d ... | Watanabe, Kengo; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2006 Aug) |
16918250
|
2006 |
| Generation of reactive intermediates. | Guengerich, F Peter | R01ES010546 | J Biochem Mol Toxicol (2005) |
15977199
|
2005 |
| Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase ... | Zang, Hong; Fang, Qingming; Pegg, Anthony E; Guengerich, F Peter | R01ES010546 | J Biol Chem (2005 Sep 02) |
16000301
|
2005 |
| Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophil ... | Guengerich, F Peter | R01ES010546 | Arch Biochem Biophys (2005 Jan 15) |
15581593
|
2005 |
| Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferas ... | Valadez, J Gerardo; Liu, Liping; Loktionova, Natalia A; Pegg, Anthony E; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2004 Jul) |
15257623
|
2004 |
| Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alky ... | Liu, Liping; Hachey, David L; Valadez, Gerardo; Williams, Kevin M; Guengerich, F Peter; Loktion ... | R01ES010546, T32ES007028 | J Biol Chem (2004 Feb 06) |
14645247
|
2004 |
| Cytochrome P450: what have we learned and what are the future issues? | Guengerich, F Peter | R01ES010546 | Drug Metab Rev (2004 May) |
15237850
|
2004 |
| Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutat ... | Marsch, Glenn A; Botta, Sisir; Martin, Martha V; McCormick, W Andrew; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2004 Jan) |
14727918
|
2004 |
| O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromom ... | Liu, Liping; Williams, Kevin M; Guengerich, F Peter; Pegg, Anthony E | R01ES010546, T32ES007028 | Chem Res Toxicol (2004 Jun) |
15206895
|
2004 |
| S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair ra ... | Valadez, J Gerardo; Guengerich, F Peter | R01ES010546 | J Biol Chem (2004 Apr 02) |
14715658
|
2004 |
| Activation of dihaloalkanes by thiol-dependent mechanisms. | Guengerich, F Peter | R01ES010546 | J Biochem Mol Biol (2003 Jan 31) |
12542971
|
2003 |
| Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione tra ... | Guengerich, F Peter; McCormick, W Andrew; Wheeler, James B | R01ES010546 | Chem Res Toxicol (2003 Nov) |
14615977
|
2003 |
| Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methy ... | Woodside, Adrienne M; Guengerich, F Peter | R01ES010546, T32ES007028 | Biochemistry (2002 Jan 22) |
11790127
|
2002 |
| Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide. | Yoshioka, Tadao; Krauser, Joel A; Guengerich, F Peter | R01ES010546, T32ES007028 | Chem Res Toxicol (2002 Nov) |
12437332
|
2002 |
| Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive po ... | Woodside, Adrienne M; Guengerich, F Peter | R01ES010546, T32ES007028 | Biochemistry (2002 Jan 22) |
11790128
|
2002 |
| Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase ... | Liu, Liping; Pegg, Anthony E; Williams, Kevin M; Guengerich, F Peter | R01ES010546, T32ES007028 | J Biol Chem (2002 Oct 04) |
12151404
|
2002 |
| Reaction of aflatoxin B(1) oxidation products with lysine. | Guengerich, F Peter; Arneson, Kyle O; Williams, Kevin M; Deng, Zhengwu; Harris, Thomas M | R01ES010546, T32ES007028 | Chem Res Toxicol (2002 Jun) |
12067245
|
2002 |
| Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine. | Guengerich, F Peter; Voehler, Markus; Williams, Kevin M; Deng, Zhengwu; Harris, Thomas M | R01ES010546, T32ES007028 | Chem Res Toxicol (2002 Jun) |
12067246
|
2002 |
| Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine. | Yoshioka, Tadao; Krauser, Joel A; Guengerich, F Peter | R01ES010546 | Chem Res Toxicol (2002 Aug) |
12184794
|
2002 |
| Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalometh ... | Wheeler, J B; Stourman, N V; Thier, R; Dommermuth, A; Vuilleumier, S; Rose, J A; Armstrong, R ... | R01ES010546 | Chem Res Toxicol (2001 Aug) |
11511186
|
2001 |
| Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal di ... | Wheeler, J B; Stourman, N V; Armstrong, R N; Guengerich, F P | R01ES010546 | Chem Res Toxicol (2001 Aug) |
11511185
|
2001 |