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Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
PI: Puga, Alvaro
Institution: University Of Cincinnati
Grant Number: R01ES010807

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 47 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES010807/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcripti ...   Zablon, Hesbon A; VonHandorf, Andrew; Puga, Alvaro R01ES010807, T32ES007250 Exp Biol Med (Maywood) (2019 06) 30935235 Exiting the NIEHS site 2019 
Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differ ...   VonHandorf, Andrew; Sánchez-Martín, Francisco Javier; Biesiada, Jacek; Zhang, Hongxia; Zhang, X ... P30ES006096, R01ES010807, T32ES007250 Epigenetics (2018) 29561703 Exiting the NIEHS site 2018 
Does the Aryl Hydrocarbon Receptor Regulate Pluripotency?   Ko, Chia-I; Puga, Alvaro P30ES006096, R01ES010807, R01ES024744, R01ES024744 Curr Opin Toxicol (2017 Feb) 28920102 Exiting the NIEHS site 2017 
Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentia ...   Wang, Qin; Kurita, Hisaka; Carreira, Vinicius; Ko, Chia-I; Fan, Yunxia; Zhang, Xiang; Biesiada ... P30ES006096, R01ES010807, R01ES024744, R01ES024744 Toxicol Sci (2016 Feb) 26572662 Exiting the NIEHS site 2016 
Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent ...   Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro P30ES006096, R01ES010807, R01ES024744, R01ES024744 Stem Cells (2016 12) 27374890 Exiting the NIEHS site 2016 
Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes.   Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Natic ... P30ES006096, R01ES010807, R01ES024744, R01ES024744 Toxicol Sci (2015 Oct) 26139165 Exiting the NIEHS site 2015 
Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and ...   Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; ... P30ES006096, R01ES010807, R01ES024744, R01ES024744 PLoS One (2015) 26555816 Exiting the NIEHS site 2015 
Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological ...   Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, ... R01ES010807 Toxicol Sci (2015 Jul) 25820237 Exiting the NIEHS site 2015 
Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead.   Sánchez-Martín, Francisco Javier; Lindquist, Diana M; Landero-Figueroa, Julio; Zhang, Xiang; Che ... P30ES006096, R01ES010807 Neurotoxicology (2015 Jan) 25530354 Exiting the NIEHS site 2015 
Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in ch ...   Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, ... R01ES010807 PLoS One (2014) 24837440 Exiting the NIEHS site 2014 
Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional ...   Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro P30ES006096, R01ES010807 Toxicology (2014 Feb 28) 24374135 Exiting the NIEHS site 2014 
Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in mur ...   Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro P30ES006096, R01ES010807, R01ES024744, R01ES024744 Stem Cell Res (2014 Jan) 24316986 Exiting the NIEHS site 2014 
The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 ...   Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro R01ES010807, R01ES024744, R01ES024744 Toxicol Sci (2014 May) 24519526 Exiting the NIEHS site 2014 
Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiatio ...   Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; ... P30ES006096, R01ES010807, R01ES024744, R01ES024744 Environ Health Perspect (2013 Nov-Dec) 24058054 Exiting the NIEHS site 2013 
Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in ne ...   Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro R01ES010807 PLoS One (2013) 24260418 Exiting the NIEHS site 2013 
Long-term exposure to hexavalent chromium inhibits expression of tumor suppressor genes in cultured ...   Fan, Yunxia; Ovesen, Jerald L; Puga, Alvaro R01ES010807 J Trace Elem Med Biol (2012 Jun) 22613061 Exiting the NIEHS site 2012 
Arsenic toxicology: translating between experimental models and human pathology.   States, J Christopher; Barchowsky, Aaron; Cartwright, Iain L; Reichard, John F; Futscher, Berna ... P30ES006096, P30ES006694, P42ES004940, R01ES010807 Environ Health Perspect (2011 Oct) 21684831 Exiting the NIEHS site 2011 
Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histo ...   Ovesen, Jerald L; Schnekenburger, Michael; Puga, Alvaro P30ES006096, R01ES010807 Toxicol Sci (2011 May) 21292640 Exiting the NIEHS site 2011 
Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease.   Puga, Alvaro P30ES006096, R01ES010807, R01ES024744, R01ES024744 Toxicol Sci (2011 Apr) 21205634 Exiting the NIEHS site 2011 
Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes.   Wang, Ying; Fan, Yunxia; Puga, Alvaro P30ES006096, R01ES010807 Toxicol Sci (2010 May) 20130022 Exiting the NIEHS site 2010 
Effects of arsenic exposure on DNA methylation and epigenetic gene regulation.   Reichard, John F; Puga, Alvaro P30ES006096, R01ES010807 Epigenomics (2010 Feb) 20514360 Exiting the NIEHS site 2010 
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.   Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro P30ES006096, R01ES010807 Cancer Res (2010 Jan 1) 19996281 Exiting the NIEHS site 2010 
Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic st ...   Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying P30ES006096, R01ES010807 Environ Health Perspect (2009 Jul) 19654923 Exiting the NIEHS site 2009 
Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene ...   Sartor, Maureen A; Schnekenburger, Michael; Marlowe, Jennifer L; Reichard, John F; Wang, Ying; ... P30ES006096, R01ES010807, T32ES007250 Environ Health Perspect (2009 Jul) 19654925 Exiting the NIEHS site 2009 
The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways.   Puga, Alvaro; Ma, Ci; Marlowe, Jennifer L P30ES006096, R01ES010807 Biochem Pharmacol (2009 Feb 15) 18817753 Exiting the NIEHS site 2009 
BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.   Reichard, John F; Sartor, Maureen A; Puga, Alvaro P30ES006096, R01ES010807, T32ES007250 J Biol Chem (2008 Aug 15) 18550526 Exiting the NIEHS site 2008 
Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its co ...   Gomez-Duran, Aurea; Ballestar, Esteban; Carvajal-Gonzalez, Jose M; Marlowe, Jennifer L; Puga, A ... P30ES006096, R01ES010807 J Mol Biol (2008 Jun 27) 18508077 Exiting the NIEHS site 2008 
Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mous ...   Peng, Li; Mayhew, Christopher N; Schnekenburger, Michael; Knudsen, Erik S; Puga, Alvaro P30ES006096, R01ES010807 Toxicology (2008 Apr 18) 18282651 Exiting the NIEHS site 2008 
The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.   Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, ... P30ES006096, R01ES010807 Mol Biol Cell (2008 Aug) 18524851 Exiting the NIEHS site 2008 
Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibitin ...   Schnekenburger, Michael; Talaska, Glenn; Puga, Alvaro P30ES006096, R01ES010807 Mol Cell Biol (2007 Oct) 17682057 Exiting the NIEHS site 2007 
HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated t ...   Schnekenburger, Michael; Peng, Li; Puga, Alvaro P30ES006096, R01ES010807 Biochim Biophys Acta (2007 Sep-Oct) 17707923 Exiting the NIEHS site 2007 
Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1.   Reichard, John F; Motz, Gregory T; Puga, Alvaro P30ES006096, R01ES010807, T32ES007250 Nucleic Acids Res (2007) 17942419 Exiting the NIEHS site 2007 
Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progress ...   Chang, Xiaoqing; Fan, Yunxia; Karyala, Saikumar; Schwemberger, Sandy; Tomlinson, Craig R; Sarto ... P30ES006096, R01ES010807 Mol Cell Biol (2007 Sep) 17606626 Exiting the NIEHS site 2007 
Long term low-dose arsenic exposure induces loss of DNA methylation.   Reichard, John F; Schnekenburger, Michael; Puga, Alvaro P30ES006096, R01ES010807, T32ES007250 Biochem Biophys Res Commun (2007 Jan 05) 17107663 Exiting the NIEHS site 2007 
Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor ...   Reichard, John F; Dalton, Timothy P; Shertzer, Howard G; Puga, Alvaro P30ES006096, R01ES010807, T32ES007250 Dose Response (2006 May 01) 18648615 Exiting the NIEHS site 2006 
Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of ph ...   Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; ... P30ES006096, R01ES010807, T32ES007250 Mol Pharmacol (2005 Aug) 15894712 Exiting the NIEHS site 2005 
Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-ind ...   Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger ... P30ES006096, R01ES010807, T32ES007250 Toxicol Sci (2005 Oct) 16014739 Exiting the NIEHS site 2005 
2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells thro ...   Barnes-Ellerbe, Sonya; Knudsen, Karen E; Puga, Alvaro P30ES006096, R01ES010807 Mol Pharmacol (2004 Sep) 15322241 Exiting the NIEHS site 2004 
Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking ...   Wei, Yu-Dan; Tepperman, Katherine; Huang, Ming-ya; Sartor, Maureen A; Puga, Alvaro P30ES006096, R01ES010807 J Biol Chem (2004 Feb 06) 14625279 Exiting the NIEHS site 2004 
Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth musc ...   Karyala, Saikumar; Guo, Junhai; Sartor, Maureen; Medvedovic, Mario; Kann, Simone; Puga, Alvaro ... P30ES006096, R01ES010807 Cardiovasc Toxicol (2004) 15034205 Exiting the NIEHS site 2004 
Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet ...   Puga, Alvaro; Sartor, Maureen A; Huang, Ming-Ya; Kerzee, J Kevin; Wei, Yu-Dan; Tomlinson, Crai ... P30ES006096, R01ES010807 Cardiovasc Toxicol (2004) 15531781 Exiting the NIEHS site 2004 
Retention of Cr(III) by high-performance chelation ion chromatography interfaced to inductively-coup ...   Vonderheide, Anne P; Meija, Juris; Tepperman, Katherine; Puga, Alvaro; Pinhas, Allan R; States, ... R01ES010807 J Chromatogr A (2004 Jan 23) 14753715 Exiting the NIEHS site 2004 
Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regula ...   Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying P30ES006096, R01ES010807 Biochem Pharmacol (2002 Sep) 12213569 Exiting the NIEHS site 2002 
Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity.   Maier, Andrew; Schumann, Brenda L; Chang, Xiaoqing; Talaska, Glenn; Puga, Alvaro P30ES006096, R01ES010807 Mutat Res (2002 May 27) 12034312 Exiting the NIEHS site 2002 
Induction of cellular oxidative stress by aryl hydrocarbon receptor activation.   Dalton, Timothy P; Puga, Alvaro; Shertzer, Howard G P30ES006096, R01ES010807 Chem Biol Interact (2002 Sep 20) 12213386 Exiting the NIEHS site 2002 
Role of the aryl hydrocarbon receptor in cell cycle regulation.   Puga, Alvaro; Xia, Ying; Elferink, Cornelis P30ES006096, R01ES010807 Chem Biol Interact (2002 Sep 20) 12213388 Exiting the NIEHS site 2002 
Dioxin exposure is an environmental risk factor for ischemic heart disease.   Dalton, T P; Kerzee, J K; Wang, B; Miller, M; Dieter, M Z; Lorenz, J N; Shertzer, H G; Nerber ... P30ES006096, R01ES010807 Cardiovasc Toxicol (2001) 12213967 Exiting the NIEHS site 2001 
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