| Project Title: | MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY |
|---|---|
| PI: | Puga, Alvaro |
| Institution: | University Of Cincinnati |
| Grant Number: | R01ES010807 |
These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcripti ... | Zablon, Hesbon A; VonHandorf, Andrew; Puga, Alvaro | R01ES010807, T32ES007250 | Exp Biol Med (Maywood) (2019 06) |
30935235
|
2019 |
| Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differ ... | VonHandorf, Andrew; Sánchez-Martín, Francisco Javier; Biesiada, Jacek; Zhang, Hongxia; Zhang, X ... | P30ES006096, R01ES010807, T32ES007250 | Epigenetics (2018) |
29561703
|
2018 |
| Does the Aryl Hydrocarbon Receptor Regulate Pluripotency? | Ko, Chia-I; Puga, Alvaro | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | Curr Opin Toxicol (2017 Feb) |
28920102
|
2017 |
| Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentia ... | Wang, Qin; Kurita, Hisaka; Carreira, Vinicius; Ko, Chia-I; Fan, Yunxia; Zhang, Xiang; Biesiada ... | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | Toxicol Sci (2016 Feb) |
26572662
|
2016 |
| Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent ... | Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | Stem Cells (2016 12) |
27374890
|
2016 |
| Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes. | Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Natic ... | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | Toxicol Sci (2015 Oct) |
26139165
|
2015 |
| Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and ... | Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; ... | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | PLoS One (2015) |
26555816
|
2015 |
| Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological ... | Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, ... | R01ES010807 | Toxicol Sci (2015 Jul) |
25820237
|
2015 |
| Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead. | Sánchez-Martín, Francisco Javier; Lindquist, Diana M; Landero-Figueroa, Julio; Zhang, Xiang; Che ... | P30ES006096, R01ES010807 | Neurotoxicology (2015 Jan) |
25530354
|
2015 |
| Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in ch ... | Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, ... | R01ES010807 | PLoS One (2014) |
24837440
|
2014 |
| Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional ... | Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro | P30ES006096, R01ES010807 | Toxicology (2014 Feb 28) |
24374135
|
2014 |
| Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in mur ... | Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | Stem Cell Res (2014 Jan) |
24316986
|
2014 |
| The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 ... | Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro | R01ES010807, R01ES024744, R01ES024744 | Toxicol Sci (2014 May) |
24519526
|
2014 |
| Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiatio ... | Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; ... | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | Environ Health Perspect (2013 Nov-Dec) |
24058054
|
2013 |
| Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in ne ... | Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro | R01ES010807 | PLoS One (2013) |
24260418
|
2013 |
| Long-term exposure to hexavalent chromium inhibits expression of tumor suppressor genes in cultured ... | Fan, Yunxia; Ovesen, Jerald L; Puga, Alvaro | R01ES010807 | J Trace Elem Med Biol (2012 Jun) |
22613061
|
2012 |
| Arsenic toxicology: translating between experimental models and human pathology. | States, J Christopher; Barchowsky, Aaron; Cartwright, Iain L; Reichard, John F; Futscher, Berna ... | P30ES006096, P30ES006694, P42ES004940, R01ES010807 | Environ Health Perspect (2011 Oct) |
21684831
|
2011 |
| Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histo ... | Ovesen, Jerald L; Schnekenburger, Michael; Puga, Alvaro | P30ES006096, R01ES010807 | Toxicol Sci (2011 May) |
21292640
|
2011 |
| Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease. | Puga, Alvaro | P30ES006096, R01ES010807, R01ES024744, R01ES024744 | Toxicol Sci (2011 Apr) |
21205634
|
2011 |
| Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes. | Wang, Ying; Fan, Yunxia; Puga, Alvaro | P30ES006096, R01ES010807 | Toxicol Sci (2010 May) |
20130022
|
2010 |
| Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. | Reichard, John F; Puga, Alvaro | P30ES006096, R01ES010807 | Epigenomics (2010 Feb) |
20514360
|
2010 |
| The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. | Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro | P30ES006096, R01ES010807 | Cancer Res (2010 Jan 1) |
19996281
|
2010 |
| Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic st ... | Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying | P30ES006096, R01ES010807 | Environ Health Perspect (2009 Jul) |
19654923
|
2009 |
| Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene ... | Sartor, Maureen A; Schnekenburger, Michael; Marlowe, Jennifer L; Reichard, John F; Wang, Ying; ... | P30ES006096, R01ES010807, T32ES007250 | Environ Health Perspect (2009 Jul) |
19654925
|
2009 |
| The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. | Puga, Alvaro; Ma, Ci; Marlowe, Jennifer L | P30ES006096, R01ES010807 | Biochem Pharmacol (2009 Feb 15) |
18817753
|
2009 |
| BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. | Reichard, John F; Sartor, Maureen A; Puga, Alvaro | P30ES006096, R01ES010807, T32ES007250 | J Biol Chem (2008 Aug 15) |
18550526
|
2008 |
| Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its co ... | Gomez-Duran, Aurea; Ballestar, Esteban; Carvajal-Gonzalez, Jose M; Marlowe, Jennifer L; Puga, A ... | P30ES006096, R01ES010807 | J Mol Biol (2008 Jun 27) |
18508077
|
2008 |
| Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mous ... | Peng, Li; Mayhew, Christopher N; Schnekenburger, Michael; Knudsen, Erik S; Puga, Alvaro | P30ES006096, R01ES010807 | Toxicology (2008 Apr 18) |
18282651
|
2008 |
| The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. | Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, ... | P30ES006096, R01ES010807 | Mol Biol Cell (2008 Aug) |
18524851
|
2008 |
| Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibitin ... | Schnekenburger, Michael; Talaska, Glenn; Puga, Alvaro | P30ES006096, R01ES010807 | Mol Cell Biol (2007 Oct) |
17682057
|
2007 |
| HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated t ... | Schnekenburger, Michael; Peng, Li; Puga, Alvaro | P30ES006096, R01ES010807 | Biochim Biophys Acta (2007 Sep-Oct) |
17707923
|
2007 |
| Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. | Reichard, John F; Motz, Gregory T; Puga, Alvaro | P30ES006096, R01ES010807, T32ES007250 | Nucleic Acids Res (2007) |
17942419
|
2007 |
| Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progress ... | Chang, Xiaoqing; Fan, Yunxia; Karyala, Saikumar; Schwemberger, Sandy; Tomlinson, Craig R; Sarto ... | P30ES006096, R01ES010807 | Mol Cell Biol (2007 Sep) |
17606626
|
2007 |
| Long term low-dose arsenic exposure induces loss of DNA methylation. | Reichard, John F; Schnekenburger, Michael; Puga, Alvaro | P30ES006096, R01ES010807, T32ES007250 | Biochem Biophys Res Commun (2007 Jan 05) |
17107663
|
2007 |
| Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor ... | Reichard, John F; Dalton, Timothy P; Shertzer, Howard G; Puga, Alvaro | P30ES006096, R01ES010807, T32ES007250 | Dose Response (2006 May 01) |
18648615
|
2006 |
| Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of ph ... | Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; ... | P30ES006096, R01ES010807, T32ES007250 | Mol Pharmacol (2005 Aug) |
15894712
|
2005 |
| Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-ind ... | Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger ... | P30ES006096, R01ES010807, T32ES007250 | Toxicol Sci (2005 Oct) |
16014739
|
2005 |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells thro ... | Barnes-Ellerbe, Sonya; Knudsen, Karen E; Puga, Alvaro | P30ES006096, R01ES010807 | Mol Pharmacol (2004 Sep) |
15322241
|
2004 |
| Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking ... | Wei, Yu-Dan; Tepperman, Katherine; Huang, Ming-ya; Sartor, Maureen A; Puga, Alvaro | P30ES006096, R01ES010807 | J Biol Chem (2004 Feb 06) |
14625279
|
2004 |
| Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth musc ... | Karyala, Saikumar; Guo, Junhai; Sartor, Maureen; Medvedovic, Mario; Kann, Simone; Puga, Alvaro ... | P30ES006096, R01ES010807 | Cardiovasc Toxicol (2004) |
15034205
|
2004 |
| Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet ... | Puga, Alvaro; Sartor, Maureen A; Huang, Ming-Ya; Kerzee, J Kevin; Wei, Yu-Dan; Tomlinson, Crai ... | P30ES006096, R01ES010807 | Cardiovasc Toxicol (2004) |
15531781
|
2004 |
| Retention of Cr(III) by high-performance chelation ion chromatography interfaced to inductively-coup ... | Vonderheide, Anne P; Meija, Juris; Tepperman, Katherine; Puga, Alvaro; Pinhas, Allan R; States, ... | R01ES010807 | J Chromatogr A (2004 Jan 23) |
14753715
|
2004 |
| Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regula ... | Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying | P30ES006096, R01ES010807 | Biochem Pharmacol (2002 Sep) |
12213569
|
2002 |
| Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity. | Maier, Andrew; Schumann, Brenda L; Chang, Xiaoqing; Talaska, Glenn; Puga, Alvaro | P30ES006096, R01ES010807 | Mutat Res (2002 May 27) |
12034312
|
2002 |
| Induction of cellular oxidative stress by aryl hydrocarbon receptor activation. | Dalton, Timothy P; Puga, Alvaro; Shertzer, Howard G | P30ES006096, R01ES010807 | Chem Biol Interact (2002 Sep 20) |
12213386
|
2002 |
| Role of the aryl hydrocarbon receptor in cell cycle regulation. | Puga, Alvaro; Xia, Ying; Elferink, Cornelis | P30ES006096, R01ES010807 | Chem Biol Interact (2002 Sep 20) |
12213388
|
2002 |
| Dioxin exposure is an environmental risk factor for ischemic heart disease. | Dalton, T P; Kerzee, J K; Wang, B; Miller, M; Dieter, M Z; Lorenz, J N; Shertzer, H G; Nerber ... | P30ES006096, R01ES010807 | Cardiovasc Toxicol (2001) |
12213967
|
2001 |