| Project Title: | DNA METHYLTRANSFERASE GENE EXPRESSION IN COLON CANCER |
|---|---|
| PI: | Baylin, Stephen B. |
| Institution: | Johns Hopkins University |
| Grant Number: | R01ES011858 |
These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.
Viewing 48 publications
Export to Excel
(http://www.niehs.nih.gov//portfolio/index.cfm?do=portfolio.grantpubdetail&&grant_number=R01ES011858&format=excel)
| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Tissue-location-specific transcription programs drive tumor dependencies in colon cancer. | Yang, Lijing; Tu, Lei; Bisht, Shilpa; Mao, Yiqing; Petkovich, Daniel; Thursby, Sara-Jayne; Lia ... | R01ES011858 | Nat Commun (2024 Feb 15) |
38360902
|
2024 |
| Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable ... | Kanholm, Tomas; Rentia, Uzma; Hadley, Melissa; Karlow, Jennifer A; Cox, Olivia L; Diab, Noor; ... | R01ES011858 | Cancer Res (2023 Aug 01) |
37249603
|
2023 |
| Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colo ... | Bhandari, Yuba R; Krishna, Vinod; Powers, Rachael; Parmar, Sehej; Thursby, Sara-Jayne; Gupta, ... | R01ES011858 | Proc Natl Acad Sci U S A (2023 Aug) |
37487069
|
2023 |
| Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenes ... | DeStefano Shields, Christina E; White, James R; Chung, Liam; Wenzel, Alyssa; Hicks, Jessica L; ... | R01ES011858 | Cancer Discov (2021 07) |
33632774
|
2021 |
| Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Indu ... | Tao, Yong; Kang, Byunghak; Petkovich, Daniel A; Bhandari, Yuba R; In, Julie; Stein-O'Brien, Ge ... | R01ES011858 | Cancer Cell (2019 Feb 11) |
30753828
|
2019 |
| Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic ... | Kong, Xiangqian; Chen, Jie; Xie, Wenbing; Brown, Stephen M; Cai, Yi; Wu, Kaichun; Fan, Daimin ... | R01ES011858 | Cancer Cell (2019 04 15) |
30956060
|
2019 |
| Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational C ... | Ye, Fei; Kong, Xiangqian; Zhang, Hao; Liu, Yan; Shao, Zhiyuan; Jin, Jia; Cai, Yi; Zhang, Ruk ... | R01ES011858 | ACS Chem Biol (2018 03 16) |
29381856
|
2018 |
| Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative S ... | Zhang, Yang W; Wang, Zhihong; Xie, Wenbing; Cai, Yi; Xia, Limin; Easwaran, Hariharan; Luo, Ji ... | R01ES011858 | Mol Cell (2017 Jan 19) |
28107650
|
2017 |
| CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor ... | Xia, Limin; Huang, Wenjie; Bellani, Marina; Seidman, Michael M; Wu, Kaichun; Fan, Daiming; Nie ... | R01ES011858 | Cancer Cell (2017 May 08) |
28486105
|
2017 |
| Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cel ... | Vaz, Michelle; Hwang, Stephen Y; Kagiampakis, Ioannis; Phallen, Jillian; Patil, Ashwini; O'Haga ... | R01ES011858 | Cancer Cell (2017 Sep 11) |
28898697
|
2017 |
| Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across ... | Cai, Yi; Tsai, Hsing-Chen; Yen, Ray-Whay Chiu; Zhang, Yang W; Kong, Xiangqian; Wang, Wei; Xia, ... | R01ES011858 | Genome Res (2017 04) |
28232479
|
2017 |
| Epigenetic Therapeutics: A New Weapon in the War Against Cancer. | Ahuja, Nita; Sharma, Anup R; Baylin, Stephen B | R01ES011858 | Annu Rev Med (2016) |
26768237
|
2016 |
| Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage. | Ding, Ning; Bonham, Emily M; Hannon, Brooke E; Amick, Thomas R; Baylin, Stephen B; O'Hagan, He ... | R01ES011858 | J Mol Cell Biol (2016 Jun) |
26186941
|
2016 |
| A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gen ... | Cui, Ying; Hausheer, Frederick; Beaty, Robert; Zahnow, Cynthia; Issa, Jean Pierre; Bunz, Frede ... | R01ES011858 | Cancer Res (2014 Jul 15) |
24876104
|
2014 |
| Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. | Easwaran, Hariharan; Tsai, Hsing-Chen; Baylin, Stephen B | R01ES011858 | Mol Cell (2014 Jun 05) |
24905005
|
2014 |
| Harnessing the potential of epigenetic therapy to target solid tumors. | Ahuja, Nita; Easwaran, Hariharan; Baylin, Stephen B | R01ES011858 | J Clin Invest (2014 Jan) |
24382390
|
2014 |
| The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor gene ... | Cai, Y; Geutjes, E-J; de Lint, K; Roepman, P; Bruurs, L; Yu, L-R; Wang, W; van Blijswijk, J; ... | R01ES011858 | Oncogene (2014 Apr 24) |
23708667
|
2014 |
| Epigenetic abnormalities in cancer find a "home on the range". | Easwaran, Hariharan; Baylin, Stephen B | R01ES011858 | Cancer Cell (2013 Jan 14) |
23328477
|
2013 |
| Novel methylation biomarker panel for the early detection of pancreatic cancer. | Yi, Joo Mi; Guzzetta, Angela A; Bailey, Vasudev J; Downing, Stephanie R; Van Neste, Leander; Ch ... | R01ES011858 | Clin Cancer Res (2013 Dec 01) |
24088737
|
2013 |
| A DNA hypermethylation module for the stem/progenitor cell signature of cancer. | Easwaran, Hariharan; Johnstone, Sarah E; Van Neste, Leander; Ohm, Joyce; Mosbruger, Tim; Wang, ... | R01ES011858 | Genome Res (2012 May) |
22391556
|
2012 |
| DNMT1 modulates gene expression without its catalytic activity partially through its interactions wi ... | Clements, Eriko G; Mohammad, Helai P; Leadem, Benjamin R; Easwaran, Hariharan; Cai, Yi; Van Nes ... | R01ES011858 | Nucleic Acids Res (2012 May) |
22278882
|
2012 |
| The cancer epigenome: its origins, contributions to tumorigenesis, and translational implications. | Baylin, Stephen B | R01ES011858 | Proc Am Thorac Soc (2012 May) |
22550245
|
2012 |
| Genomic and epigenomic integration identifies a prognostic signature in colon cancer. | Yi, Joo Mi; Dhir, Mashaal; Van Neste, Leander; Downing, Stephanie R; Jeschke, Jana; Glöckner, ... | R01ES011858 | Clin Cancer Res (2011 Mar 15) |
21278247
|
2011 |
| Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice. | Mohammad, H P; Zhang, W; Prevas, H S; Leadem, B R; Zhang, M; Herman, J G; Hooker, C M; Watkin ... | R01ES011858 | Oncogene (2011 Jun 9) |
21297660
|
2011 |
| Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to ... | O'Hagan, Heather M; Wang, Wei; Sen, Subhojit; Destefano Shields, Christina; Lee, Stella S; Zhan ... | R01ES011858, T32ES007141 | Cancer Cell (2011 Nov 15) |
22094255
|
2011 |
| Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spa ... | Easwaran, Hariharan P; Van Neste, Leander; Cope, Leslie; Sen, Subhojit; Mohammad, Helai P; Page ... | R01ES011858 | Cancer Res (2010 Oct 15) |
20736368
|
2010 |
| Mapping networks of protein-mediated physical interactions between chromatin elements. | Tiwari, Vijay K; Baylin, Stephen B | R01ES011858 | Curr Protoc Mol Biol (2010 Jan) |
20069537
|
2010 |
| Role of nuclear architecture in epigenetic alterations in cancer. | Easwaran, H P; Baylin, S B | R01ES011858 | Cold Spring Harb Symp Quant Biol (2010) |
21447817
|
2010 |
| Stress and the epigenetic landscape: a link to the pathobiology of human diseases? | Johnstone, Sarah E; Baylin, Stephen B | R01ES011858 | Nat Rev Genet (2010 Nov) |
20921961
|
2010 |
| A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. | Tiwari, Vijay K; Cope, Leslie; McGarvey, Kelly M; Ohm, Joyce E; Baylin, Stephen B | R01ES011858 | Genome Res (2008 Jul) |
18502945
|
2008 |
| A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. | Ting, Angela H; Suzuki, Hiromu; Cope, Leslie; Schuebel, Kornel E; Lee, Byron H; Toyota, Minoru ... | R01ES011858 | Cancer Res (2008 Apr 15) |
18413723
|
2008 |
| Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. | Yi, Joo Mi; Tsai, Hsing-Chen; Glöckner, Sabine C; Lin, Steven; Ohm, Joyce E; Easwaran, Hari; J ... | R01ES011858 | Cancer Res (2008 Oct 01) |
18829568
|
2008 |
| Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict fo ... | Chan, Timothy A; Glockner, Sabine; Yi, Joo Mi; Chen, Wei; Van Neste, Leander; Cope, Leslie; He ... | R01ES011858 | PLoS Med (2008 May 27) |
18507500
|
2008 |
| Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells. | McGarvey, Kelly M; Van Neste, Leander; Cope, Leslie; Ohm, Joyce E; Herman, James G; Van Criekin ... | R01ES011858 | Cancer Res (2008 Jul 15) |
18632628
|
2008 |
| Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal can ... | Zhang, Wei; Glöckner, Sabine C; Guo, Mingzhou; Machida, Emi Ota; Wang, David H; Easwaran, Hari ... | R01ES011858 | Cancer Res (2008 Apr 15) |
18413743
|
2008 |
| PcG proteins, DNA methylation, and gene repression by chromatin looping. | Tiwari, Vijay K; McGarvey, Kelly M; Licchesi, Julien D F; Ohm, Joyce E; Herman, James G; Schübe ... | R01ES011858 | PLoS Biol (2008 Dec 02) |
19053175
|
2008 |
| Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. | Schuebel, Kornel E; Chen, Wei; Cope, Leslie; Glöckner, Sabine C; Suzuki, Hiromu; Yi, Joo-Mi; C ... | R01ES011858 | PLoS Genet (2007 Sep) |
17892325
|
2007 |
| DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZ ... | McGarvey, Kelly M; Greene, Eriko; Fahrner, Jill A; Jenuwein, Thomas; Baylin, Stephen B | R01ES011858 | Cancer Res (2007 Jun 1) |
17545586
|
2007 |
| hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethyl ... | Zinn, Rebekah L; Pruitt, Kevin; Eguchi, Sayaka; Baylin, Stephen B; Herman, James G | R01ES011858 | Cancer Res (2007 Jan 1) |
17210699
|
2007 |
| Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberra ... | Huang, Yi; Greene, Eriko; Murray Stewart, Tracy; Goodwin, Andrew C; Baylin, Stephen B; Woster, ... | R01ES011858 | Proc Natl Acad Sci U S A (2007 May 8) |
17463086
|
2007 |
| The epigenomics of cancer. | Jones, Peter A; Baylin, Stephen B | R01ES011858 | Cell (2007 Feb 23) |
17320506
|
2007 |
| De novo CpG island methylation in human cancer cells. | Jair, Kam-Wing; Bachman, Kurtis E; Suzuki, Hiromu; Ting, Angela H; Rhee, Ina; Yen, Ray-Whay Ch ... | R01ES011858 | Cancer Res (2006 Jan 15) |
16423997
|
2006 |
| Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter ... | Ting, Angela H; Jair, Kam-wing; Schuebel, Kornel E; Baylin, Stephen B | R01ES011858 | Cancer Res (2006 Jan 15) |
16424002
|
2006 |
| Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromati ... | McGarvey, Kelly M; Fahrner, Jill A; Greene, Eriko; Martens, Joost; Jenuwein, Thomas; Baylin, S ... | R01ES011858 | Cancer Res (2006 Apr 1) |
16585178
|
2006 |
| Aberrant gene silencing in tumor progression: implications for control of cancer. | Baylin, S B; Chen, W Y | R01ES011858 | Cold Spring Harb Symp Quant Biol (2005) |
16869780
|
2005 |
| GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epi ... | Akiyama, Yoshimitsu; Watkins, Neil; Suzuki, Hiromu; Jair, Kam-Wing; van Engeland, Manon; Estell ... | R01ES011858 | Mol Cell Biol (2003 Dec) |
14612389
|
2003 |
| Gene silencing in cancer in association with promoter hypermethylation. | Herman, James G; Baylin, Stephen B | R01ES011858 | N Engl J Med (2003 Nov 20) |
14627790
|
2003 |
| Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. | Fahrner, Jill A; Eguchi, Sayaka; Herman, James G; Baylin, Stephen B | R01ES011858 | Cancer Res (2002 Dec 15) |
12499261
|
2002 |