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Who We Fund: Publication Detail

Project Title: DNA METHYLTRANSFERASE GENE EXPRESSION IN COLON CANCER
PI: Baylin, Stephen B.
Institution: Johns Hopkins University
Grant Number: R01ES011858

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 44 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES011858/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Indu ...   Tao, Yong; Kang, Byunghak; Petkovich, Daniel A; Bhandari, Yuba R; In, Julie; Stein-O'Brien, Ge ... R01ES011858 Cancer Cell (2019 02 11) 30753828 Exiting the NIEHS site 2019 
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic ...   Kong, Xiangqian; Chen, Jie; Xie, Wenbing; Brown, Stephen M; Cai, Yi; Wu, Kaichun; Fan, Daimin ... R01ES011858 Cancer Cell (2019 04 15) 30956060 Exiting the NIEHS site 2019 
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational C ...   Ye, Fei; Kong, Xiangqian; Zhang, Hao; Liu, Yan; Shao, Zhiyuan; Jin, Jia; Cai, Yi; Zhang, Ruk ... R01ES011858 ACS Chem Biol (2018 03 16) 29381856 Exiting the NIEHS site 2018 
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative S ...   Zhang, Yang W; Wang, Zhihong; Xie, Wenbing; Cai, Yi; Xia, Limin; Easwaran, Hariharan; Luo, Ji ... R01ES011858 Mol Cell (2017 Jan 19) 28107650 Exiting the NIEHS site 2017 
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor ...   Xia, Limin; Huang, Wenjie; Bellani, Marina; Seidman, Michael M; Wu, Kaichun; Fan, Daiming; Nie ... R01ES011858 Cancer Cell (2017 05 08) 28486105 Exiting the NIEHS site 2017 
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cel ...   Vaz, Michelle; Hwang, Stephen Y; Kagiampakis, Ioannis; Phallen, Jillian; Patil, Ashwini; O'Haga ... R01ES011858 Cancer Cell (2017 09 11) 28898697 Exiting the NIEHS site 2017 
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across ...   Cai, Yi; Tsai, Hsing-Chen; Yen, Ray-Whay Chiu; Zhang, Yang W; Kong, Xiangqian; Wang, Wei; Xia, ... R01ES011858 Genome Res (2017 04) 28232479 Exiting the NIEHS site 2017 
Epigenetic Therapeutics: A New Weapon in the War Against Cancer.   Ahuja, Nita; Sharma, Anup R; Baylin, Stephen B R01ES011858 Annu Rev Med (2016) 26768237 Exiting the NIEHS site 2016 
Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.   Ding, Ning; Bonham, Emily M; Hannon, Brooke E; Amick, Thomas R; Baylin, Stephen B; O'Hagan, He ... R01ES011858 J Mol Cell Biol (2016 06) 26186941 Exiting the NIEHS site 2016 
A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gen ...   Cui, Ying; Hausheer, Frederick; Beaty, Robert; Zahnow, Cynthia; Issa, Jean Pierre; Bunz, Frede ... R01ES011858 Cancer Res (2014 Jul 15) 24876104 Exiting the NIEHS site 2014 
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.   Easwaran, Hariharan; Tsai, Hsing-Chen; Baylin, Stephen B R01ES011858 Mol Cell (2014 Jun 5) 24905005 Exiting the NIEHS site 2014 
Harnessing the potential of epigenetic therapy to target solid tumors.   Ahuja, Nita; Easwaran, Hariharan; Baylin, Stephen B R01ES011858 J Clin Invest (2014 Jan) 24382390 Exiting the NIEHS site 2014 
The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor gene ...   Cai, Y; Geutjes, E-J; de Lint, K; Roepman, P; Bruurs, L; Yu, L-R; Wang, W; van Blijswijk, J; ... R01ES011858 Oncogene (2014 Apr 24) 23708667 Exiting the NIEHS site 2014 
Epigenetic abnormalities in cancer find a "home on the range".   Easwaran, Hariharan; Baylin, Stephen B R01ES011858 Cancer Cell (2013 Jan 14) 23328477 Exiting the NIEHS site 2013 
Novel methylation biomarker panel for the early detection of pancreatic cancer.   Yi, Joo Mi; Guzzetta, Angela A; Bailey, Vasudev J; Downing, Stephanie R; Van Neste, Leander; Ch ... R01ES011858 Clin Cancer Res (2013 Dec 01) 24088737 Exiting the NIEHS site 2013 
A DNA hypermethylation module for the stem/progenitor cell signature of cancer.   Easwaran, Hariharan; Johnstone, Sarah E; Van Neste, Leander; Ohm, Joyce; Mosbruger, Tim; Wang, ... R01ES011858 Genome Res (2012 May) 22391556 Exiting the NIEHS site 2012 
DNMT1 modulates gene expression without its catalytic activity partially through its interactions wi ...   Clements, Eriko G; Mohammad, Helai P; Leadem, Benjamin R; Easwaran, Hariharan; Cai, Yi; Van Nes ... R01ES011858 Nucleic Acids Res (2012 May) 22278882 Exiting the NIEHS site 2012 
The cancer epigenome: its origins, contributions to tumorigenesis, and translational implications.   Baylin, Stephen B R01ES011858 Proc Am Thorac Soc (2012 May) 22550245 Exiting the NIEHS site 2012 
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.   Yi, Joo Mi; Dhir, Mashaal; Van Neste, Leander; Downing, Stephanie R; Jeschke, Jana; Glöckner, ... R01ES011858 Clin Cancer Res (2011 Mar 15) 21278247 Exiting the NIEHS site 2011 
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.   Mohammad, H P; Zhang, W; Prevas, H S; Leadem, B R; Zhang, M; Herman, J G; Hooker, C M; Watkin ... R01ES011858 Oncogene (2011 Jun 9) 21297660 Exiting the NIEHS site 2011 
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to ...   O'Hagan, Heather M; Wang, Wei; Sen, Subhojit; Destefano Shields, Christina; Lee, Stella S; Zhan ... R01ES011858, T32ES007141 Cancer Cell (2011 Nov 15) 22094255 Exiting the NIEHS site 2011 
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spa ...   Easwaran, Hariharan P; Van Neste, Leander; Cope, Leslie; Sen, Subhojit; Mohammad, Helai P; Page ... R01ES011858 Cancer Res (2010 Oct 15) 20736368 Exiting the NIEHS site 2010 
Mapping networks of protein-mediated physical interactions between chromatin elements.   Tiwari, Vijay K; Baylin, Stephen B R01ES011858 Curr Protoc Mol Biol (2010 Jan) 20069537 Exiting the NIEHS site 2010 
Role of nuclear architecture in epigenetic alterations in cancer.   Easwaran, H P; Baylin, S B R01ES011858 Cold Spring Harb Symp Quant Biol (2010) 21447817 Exiting the NIEHS site 2010 
Stress and the epigenetic landscape: a link to the pathobiology of human diseases?   Johnstone, Sarah E; Baylin, Stephen B R01ES011858 Nat Rev Genet (2010 Nov) 20921961 Exiting the NIEHS site 2010 
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations.   Tiwari, Vijay K; Cope, Leslie; McGarvey, Kelly M; Ohm, Joyce E; Baylin, Stephen B R01ES011858 Genome Res (2008 Jul) 18502945 Exiting the NIEHS site 2008 
A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.   Ting, Angela H; Suzuki, Hiromu; Cope, Leslie; Schuebel, Kornel E; Lee, Byron H; Toyota, Minoru ... R01ES011858 Cancer Res (2008 Apr 15) 18413723 Exiting the NIEHS site 2008 
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.   Yi, Joo Mi; Tsai, Hsing-Chen; Glöckner, Sabine C; Lin, Steven; Ohm, Joyce E; Easwaran, Hari; J ... R01ES011858 Cancer Res (2008 Oct 01) 18829568 Exiting the NIEHS site 2008 
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict fo ...   Chan, Timothy A; Glockner, Sabine; Yi, Joo Mi; Chen, Wei; Van Neste, Leander; Cope, Leslie; He ... R01ES011858 PLoS Med (2008 May 27) 18507500 Exiting the NIEHS site 2008 
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells.   McGarvey, Kelly M; Van Neste, Leander; Cope, Leslie; Ohm, Joyce E; Herman, James G; Van Criekin ... R01ES011858 Cancer Res (2008 Jul 15) 18632628 Exiting the NIEHS site 2008 
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal can ...   Zhang, Wei; Glöckner, Sabine C; Guo, Mingzhou; Machida, Emi Ota; Wang, David H; Easwaran, Hari ... R01ES011858 Cancer Res (2008 Apr 15) 18413743 Exiting the NIEHS site 2008 
PcG proteins, DNA methylation, and gene repression by chromatin looping.   Tiwari, Vijay K; McGarvey, Kelly M; Licchesi, Julien D F; Ohm, Joyce E; Herman, James G; Schübe ... R01ES011858 PLoS Biol (2008 Dec 02) 19053175 Exiting the NIEHS site 2008 
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.   Schuebel, Kornel E; Chen, Wei; Cope, Leslie; Glöckner, Sabine C; Suzuki, Hiromu; Yi, Joo-Mi; C ... R01ES011858 PLoS Genet (2007 Sep) 17892325 Exiting the NIEHS site 2007 
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZ ...   McGarvey, Kelly M; Greene, Eriko; Fahrner, Jill A; Jenuwein, Thomas; Baylin, Stephen B R01ES011858 Cancer Res (2007 Jun 1) 17545586 Exiting the NIEHS site 2007 
hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethyl ...   Zinn, Rebekah L; Pruitt, Kevin; Eguchi, Sayaka; Baylin, Stephen B; Herman, James G R01ES011858 Cancer Res (2007 Jan 1) 17210699 Exiting the NIEHS site 2007 
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberra ...   Huang, Yi; Greene, Eriko; Murray Stewart, Tracy; Goodwin, Andrew C; Baylin, Stephen B; Woster, ... R01ES011858 Proc Natl Acad Sci U S A (2007 May 8) 17463086 Exiting the NIEHS site 2007 
The epigenomics of cancer.   Jones, Peter A; Baylin, Stephen B R01ES011858 Cell (2007 Feb 23) 17320506 Exiting the NIEHS site 2007 
De novo CpG island methylation in human cancer cells.   Jair, Kam-Wing; Bachman, Kurtis E; Suzuki, Hiromu; Ting, Angela H; Rhee, Ina; Yen, Ray-Whay Ch ... R01ES011858 Cancer Res (2006 Jan 15) 16423997 Exiting the NIEHS site 2006 
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter ...   Ting, Angela H; Jair, Kam-wing; Schuebel, Kornel E; Baylin, Stephen B R01ES011858 Cancer Res (2006 Jan 15) 16424002 Exiting the NIEHS site 2006 
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromati ...   McGarvey, Kelly M; Fahrner, Jill A; Greene, Eriko; Martens, Joost; Jenuwein, Thomas; Baylin, S ... R01ES011858 Cancer Res (2006 Apr 1) 16585178 Exiting the NIEHS site 2006 
Aberrant gene silencing in tumor progression: implications for control of cancer.   Baylin, S B; Chen, W Y R01ES011858 Cold Spring Harb Symp Quant Biol (2005) 16869780 Exiting the NIEHS site 2005 
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epi ...   Akiyama, Yoshimitsu; Watkins, Neil; Suzuki, Hiromu; Jair, Kam-Wing; van Engeland, Manon; Estell ... R01ES011858 Mol Cell Biol (2003 Dec) 14612389 Exiting the NIEHS site 2003 
Gene silencing in cancer in association with promoter hypermethylation.   Herman, James G; Baylin, Stephen B R01ES011858 N Engl J Med (2003 Nov 20) 14627790 Exiting the NIEHS site 2003 
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.   Fahrner, Jill A; Eguchi, Sayaka; Herman, James G; Baylin, Stephen B R01ES011858 Cancer Res (2002 Dec 15) 12499261 Exiting the NIEHS site 2002 
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