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Your Environment. Your Health.

Who We Fund: Publication Detail

PI: Tomkinson, Alan E
Institution: University Of New Mexico Health Scis Ctr
Grant Number: R01ES012512

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 37 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα wit ...   Hammel, Michal; Rashid, Ishtiaque; Sverzhinsky, Aleksandr; Pourfarjam, Yasin; Tsai, Miaw-Sheue; ... R01ES012512 Nucleic Acids Res (2021 01 11) 33330937 Exiting the NIEHS site 2021 
Human DNA ligases in replication and repair.   Sallmyr, Annahita; Rashid, Ishtiaque; Bhandari, Seema Khattri; Naila, Tasmin; Tomkinson, Alan E R01ES012512 DNA Repair (Amst) (2020 09) 33087274 Exiting the NIEHS site 2020 
1HN, 13C, and 15N backbone resonance assignments of the human DNA ligase 3 DNA-binding domain (resid ...   Roth, Braden M; Varney, Kristen M; Yang, Hui; Weber, David J; Tomkinson, Alan E R01ES012512 Biomol NMR Assign (2019 10) 31093909 Exiting the NIEHS site 2019 
1HN, 13C, and 15N resonance assignments of human calmodulin bound to a peptide derived from the STRA ...   Varney, Kristen M; Wilder, Paul T; Godoy-Ruiz, Raquel; Mancia, Filippo; Weber, David J R01ES012512 Biomol NMR Assign (2019 10) 30875027 Exiting the NIEHS site 2019 
SUMOning the base excision repair machinery for differentiation.   Wiest, Nathaniel E; Tomkinson, Alan E R01ES012512 EMBO J (2019 01 03) 30545824 Exiting the NIEHS site 2019 
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Scl ...   Wang, Haibo; Guo, Wenting; Mitra, Joy; Hegde, Pavana M; Vandoorne, Tijs; Eckelmann, Bradley J; ... R01ES012512 Nat Commun (2018 09 11) 30206235 Exiting the NIEHS site 2018 
Repair of DNA double-strand breaks by mammalian alternative end-joining pathways.   Sallmyr, Annahita; Tomkinson, Alan E R01ES012512 J Biol Chem (2018 07 06) 29530982 Exiting the NIEHS site 2018 
Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncomp ...   Howes, Timothy R L; Sallmyr, Annahita; Brooks, Rhys; Greco, George E; Jones, Darin E; Matsumoto ... R01ES012512 DNA Repair (Amst) (2017 12) 29078112 Exiting the NIEHS site 2017 
The Human Ligase IIIα-XRCC1 Protein Complex Performs DNA Nick Repair after Transient Unwrapping of N ...   Cannan, Wendy J; Rashid, Ishtiaque; Tomkinson, Alan E; Wallace, Susan S; Pederson, David S R01ES012512 J Biol Chem (2017 Mar 31) 28184006 Exiting the NIEHS site 2017 
Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells.   Sallmyr, Annahita; Matsumoto, Yoshihiro; Roginskaya, Vera; Van Houten, Bennett; Tomkinson, Alan ... R01ES012512 Cancer Res (2016 09 15) 27503931 Exiting the NIEHS site 2016 
SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV.   Greco, George E; Matsumoto, Yoshihiro; Brooks, Rhys C; Lu, Zhengfei; Lieber, Michael R; Tomkins ... R01ES012512 DNA Repair (Amst) (2016 07) 27235626 Exiting the NIEHS site 2016 
Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.   Kukshal, Vandna; Kim, In-Kwon; Hura, Gregory L; Tomkinson, Alan E; Tainer, John A; Ellenberger, ... R01ES012512 Nucleic Acids Res (2015 Aug 18) 26130724 Exiting the NIEHS site 2015 
Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.   Ghezraoui, Hind; Piganeau, Marion; Renouf, Benjamin; Renaud, Jean-Baptiste; Sallmyr, Annahita; ... R01ES012512 Mol Cell (2014 Sep 18) 25201414 Exiting the NIEHS site 2014 
DNA ligases as therapeutic targets.   Tomkinson, Alan E; Howes, Timothy R L; Wiest, Nathaniel E R01ES012512 Transl Cancer Res (2013 Jun) 24224145 Exiting the NIEHS site 2013 
Structure and function of the DNA ligases encoded by the mammalian LIG3 gene.   Tomkinson, Alan E; Sallmyr, Annahita R01ES012512 Gene (2013 Dec 01) 24013086 Exiting the NIEHS site 2013 
Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic mye ...   Tobin, L A; Robert, C; Rapoport, A P; Gojo, I; Baer, M R; Tomkinson, A E; Rassool, F V R01ES012512 Oncogene (2013 Apr 04) 22641215 Exiting the NIEHS site 2013 
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the hum ...   Dey, Sanjib; Maiti, Amit K; Hegde, Muralidhar L; Hegde, Pavana M; Boldogh, Istvan; Sarkar, Par ... R01ES012512 DNA Repair (Amst) (2012 Jun 01) 22497777 Exiting the NIEHS site 2012 
Targeting abnormal DNA repair in therapy-resistant breast cancers.   Tobin, Lisa A; Robert, Carine; Nagaria, Pratik; Chumsri, Saranya; Twaddell, William; Ioffe, Ol ... R01ES012512 Mol Cancer Res (2012 Jan) 22112941 Exiting the NIEHS site 2012 
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critic ...   Della-Maria, Julie; Hegde, Muralidhar L; McNeill, Daniel R; Matsumoto, Yoshihiro; Tsai, Miaw-Sh ... R01ES012512 J Biol Chem (2012 Nov 09) 22992732 Exiting the NIEHS site 2012 
The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision ...   Goula, Agathi-Vasiliki; Pearson, Christopher E; Della Maria, Julie; Trottier, Yvon; Tomkinson, ... R01ES012512 Biochemistry (2012 May 8) 22497302 Exiting the NIEHS site 2012 
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alte ...   Della-Maria, Julie; Zhou, Yi; Tsai, Miaw-Sheue; Kuhnlein, Jeff; Carney, James P; Paull, Tanya ... R01ES012512 J Biol Chem (2011 Sep 30) 21816818 Exiting the NIEHS site 2011 
Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair.   Odell, Ian D; Barbour, Joy-El; Murphy, Drew L; Della-Maria, Julie A; Sweasy, Joann B; Tomkinson ... R01ES012512 Mol Cell Biol (2011 Nov) 21930793 Exiting the NIEHS site 2011 
Replication protein A safeguards genome integrity by controlling NER incision events.   Overmeer, René M; Moser, Jill; Volker, Marcel; Kool, Hanneke; Tomkinson, Alan E; van Zeeland, ... R01ES012512 J Cell Biol (2011 Feb 07) 21282463 Exiting the NIEHS site 2011 
Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ova ...   Berquist, Brian R; Singh, Dharmendra Kumar; Fan, Jinshui; Kim, Daemyung; Gillenwater, Elizabeth ... R01ES012512 Nucleic Acids Res (2010 Aug) 20385586 Exiting the NIEHS site 2010 
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.   Cotner-Gohara, Elizabeth; Kim, In-Kwon; Hammel, Michal; Tainer, John A; Tomkinson, Alan E; Elle ... R01ES012512 Biochemistry (2010 Jul 27) 20518483 Exiting the NIEHS site 2010 
Targeting abnormal DNA double strand break repair in cancer.   Rassool, Feyruz V; Tomkinson, Alan E R01ES012512 Cell Mol Life Sci (2010 Nov) 20697770 Exiting the NIEHS site 2010 
Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing abilit ...   Chen, Xi; Ballin, Jeff D; Della-Maria, Julie; Tsai, Miaw-Sheue; White, Elizabeth J; Tomkinson, ... R01ES012512 DNA Repair (Amst) (2009 Aug 6) 19589734 Exiting the NIEHS site 2009 
Eukaryotic DNA ligases: structural and functional insights.   Ellenberger, Tom; Tomkinson, Alan E R01ES012512 Annu Rev Biochem (2008) 18518823 Exiting the NIEHS site 2008 
Identification and validation of human DNA ligase inhibitors using computer-aided drug design.   Zhong, Shijun; Chen, Xi; Zhu, Xiao; Dziegielewska, Barbara; Bachman, Kurtis E; Ellenberger, To ... R01ES012512 J Med Chem (2008 Aug 14) 18630893 Exiting the NIEHS site 2008 
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.   Chen, Xi; Zhong, Shijun; Zhu, Xiao; Dziegielewska, Barbara; Ellenberger, Tom; Wilson, Gerald M ... R01ES012512 Cancer Res (2008 May 1) 18451142 Exiting the NIEHS site 2008 
Two DNA-binding and nick recognition modules in human DNA ligase III.   Cotner-Gohara, Elizabeth; Kim, In-Kwon; Tomkinson, Alan E; Ellenberger, Tom R01ES012512 J Biol Chem (2008 Apr 18) 18238776 Exiting the NIEHS site 2008 
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repai ...   Sallmyr, Annahita; Tomkinson, Alan E; Rassool, Feyruz V R01ES012512 Blood (2008 Aug 15) 18524993 Exiting the NIEHS site 2008 
ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIalpha.   Dong, Zhiwan; Tomkinson, Alan E R01ES012512 Nucleic Acids Res (2006) 17040896 Exiting the NIEHS site 2006 
DNA ligases: structure, reaction mechanism, and function.   Tomkinson, Alan E; Vijayakumar, Sangeetha; Pascal, John M; Ellenberger, Tom R01ES012512 Chem Rev (2006 Feb) 16464020 Exiting the NIEHS site 2006 
Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes.   Chen, Xi; Pascal, John; Vijayakumar, Sangeetha; Wilson, Gerald M; Ellenberger, Tom; Tomkinson, ... R01ES012512 Methods Enzymol (2006) 16793394 Exiting the NIEHS site 2006 
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in h ...   Das, Aditi; Wiederhold, Lee; Leppard, John B; Kedar, Padmini; Prasad, Rajendra; Wang, Huxian; ... R01ES012512 DNA Repair (Amst) (2006 Dec 09) 16982218 Exiting the NIEHS site 2006 
Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA da ...   Okano, Satoshi; Lan, Li; Tomkinson, Alan E; Yasui, Akira R01ES012512 Nucleic Acids Res (2005) 15653642 Exiting the NIEHS site 2005 
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