| Project Title: | ROLE OF ALVEOLAR MACROPHAGES IN PARTICULATE MATTER-INDUCED CARDIOPULMONARY DISEASE |
|---|---|
| PI: | Mutlu, Gokhan M. |
| Institution: | University Of Chicago |
| Grant Number: | R01ES015024 |
These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contra ... | Cetin-Atalay, Rengul; Meliton, Angelo Y; Ozcan, Cevher; Woods, Parker S; Sun, Kaitlyn A; Fang, ... | R01ES015024 | PLoS One (2023) |
37844118
|
2023 |
| HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survi ... | Woods, Parker S; Kimmig, Lucas M; Sun, Kaitlyn A; Meliton, Angelo Y; Shamaa, Obada R; Tian, Yu ... | R01ES015024 | Elife (2022 Jul 13) |
35822617
|
2022 |
| Our Compliments to the Authors: Decay Accelerating Factor and the Complement System in Pulmonary Fib ... | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2022 Oct) |
35901283
|
2022 |
| Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism. | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | FEBS J (2021 11) |
33393204
|
2021 |
| More to Explore: Further Definition of Risk Factors for COPD - Differential Gender Difference, Modes ... | Zhang, Yixuan; Wang, Lu; Mutlu, Gökhan M; Cai, Hua | R01ES015024 | Front Physiol (2021) |
34025456
|
2021 |
| Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cell ... | Wu, David; Harrison, Devin L; Szasz, Teodora; Yeh, Chih-Fan; Shentu, Tzu-Pin; Meliton, Angelo; ... | R01ES015024 | Nat Metab (2021 May) |
34031595
|
2021 |
| The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging. | McQuattie-Pimentel, Alexandra C; Ren, Ziyou; Joshi, Nikita; Watanabe, Satoshi; Stoeger, Thomas; ... | R01ES015024 | J Clin Invest (2021 02 15) |
33586677
|
2021 |
| The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production ... | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Amino Acids (2021 Dec) |
33963932
|
2021 |
| Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory ... | Sun, Kaitlyn A; Li, Yan; Meliton, Angelo Y; Woods, Parker S; Kimmig, Lucas M; Cetin-Atalay, Re ... | R01ES015024 | Elife (2020 04 07) |
32255424
|
2020 |
| The Airway Epithelial Response to Air Pollution: It's Not Just Inflammation. | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2020 08) |
32311285
|
2020 |
| Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation. | Woods, Parker S; Kimmig, Lucas M; Meliton, Angelo Y; Sun, Kaitlyn A; Tian, Yufeng; O'Leary, Er ... | R01ES015024 | Am J Respir Cell Mol Biol (2020 02) |
31469581
|
2020 |
| Air Pollution, Asthma, and Sleep Apnea: New Epidemiological Links? | Mutlu, Gökhan M; Peker, Yüksel | R01ES015024 | Ann Am Thorac Soc (2019 Mar) |
31339334
|
2019 |
| Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury. | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2019 02) |
30278142
|
2019 |
| Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. | Hamanaka, Robert B; O'Leary, Erin M; Witt, Leah J; Tian, Yufeng; Gökalp, Gizem A; Meliton, Ang ... | R01ES015024 | Am J Respir Cell Mol Biol (2019 11) |
30973753
|
2019 |
| Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. | Soberanes, Saul; Misharin, Alexander V; Jairaman, Amit; Morales-Nebreda, Luisa; McQuattie-Piment ... | R01ES015024 | Cell Metab (2019 02 05) |
30318339
|
2019 |
| Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmona ... | Reyfman, Paul A; Walter, James M; Joshi, Nikita; Anekalla, Kishore R; McQuattie-Pimentel, Alexa ... | R01ES015024 | Am J Respir Crit Care Med (2019 06 15) |
30554520
|
2019 |
| Inhalational exposure to particulate matter air pollution alters the composition of the gut microbio ... | Mutlu, Ece A; Comba, Işın Y; Cho, Takugo; Engen, Phillip A; Yazıcı, Cemal; Soberanes, Saul; Ha ... | R01ES015024 | Environ Pollut (2018 Sep) |
29783199
|
2018 |
| Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. | Hamanaka, Robert B; Nigdelioglu, Recep; Meliton, Angelo Y; Tian, Yufeng; Witt, Leah J; O'Leary, ... | R01ES015024 | Am J Respir Cell Mol Biol (2018 May) |
29019702
|
2018 |
| Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Leve ... | Mutlu, Gökhan M; Budinger, G R Scott | R01ES015024 | Circulation (2018 03 13) |
29530899
|
2018 |
| Particulate Matter Air Pollution: Effects on the Cardiovascular System. | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Front Endocrinol (Lausanne) (2018) |
30505291
|
2018 |
| Role of Cellular Metabolism in Pulmonary Diseases. | Wu, David; Woods, Parker S; Duong, Heng T; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2018 07) |
29634283
|
2018 |
| Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regu ... | Huang, Ru-Ting; Wu, David; Meliton, Angelo; Oh, Myung-Jin; Krause, Matthew; Lloyd, Joyce A; Ni ... | R01ES015024 | Am J Respir Crit Care Med (2017 03 01) |
27855271
|
2017 |
| HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular ... | Wu, David; Huang, Ru-Ting; Hamanaka, Robert B; Krause, Matt; Oh, Myung-Jin; Kuo, Cheng-Hsiang; ... | R01ES015024 | Elife (2017 05 30) |
28556776
|
2017 |
| Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1α Drives E ... | Wu, David; Hamanaka, Robert B; Fang, Yun; Mutlu, Gökhan M | R01ES015024 | Arterioscler Thromb Vasc Biol (2017 12) |
29162600
|
2017 |
| Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span ... | Misharin, Alexander V; Morales-Nebreda, Luisa; Reyfman, Paul A; Cuda, Carla M; Walter, James M; ... | R01ES015024 | J Exp Med (2017 Aug 07) |
28694385
|
2017 |
| PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epider ... | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | J Invest Dermatol (2017 06) |
28108301
|
2017 |
| Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. | Peteranderl, Christin; Morales-Nebreda, Luisa; Selvakumar, Balachandar; Lecuona, Emilia; Vadász, ... | R01ES015024 | J Clin Invest (2016 Apr 01) |
26999599
|
2016 |
| Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. | Nigdelioglu, Recep; Hamanaka, Robert B; Meliton, Angelo Y; O'Leary, Erin; Witt, Leah J; Cho, T ... | R01ES015024 | J Biol Chem (2016 Dec 30) |
27836973
|
2016 |
| Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans. | Bharat, Ankit; Cunningham, Scott A; Scott Budinger, G R; Kreisel, Daniel; DeWet, Charl J; Gelma ... | R01ES015024 | Sci Transl Med (2015 Apr 22) |
25904745
|
2015 |
| Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis. | Morales-Nebreda, Luisa I; Rogel, Micah R; Eisenberg, Jessica L; Hamill, Kevin J; Soberanes, Sau ... | R01ES015024 | Am J Respir Cell Mol Biol (2015 Apr) |
25188360
|
2015 |
| Muscle dysfunction in patients with lung diseases: a growing epidemic. | Barreiro, Esther; Sznajder, Jacob I; Nader, Gustavo A; Budinger, G R Scott | R01ES015024 | Am J Respir Crit Care Med (2015 Mar 15) |
25767924
|
2015 |
| Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect. | Ghio, Andrew J; Soukup, Joleen M; Dailey, Lisa A; Tong, Haiyan; Kesic, Matthew J; Budinger, G ... | R01ES015024 | Chem Res Toxicol (2015 Nov 16) |
26462088
|
2015 |
| β₂-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe ... | Chiarella, Sergio E; Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | J Allergy Clin Immunol (2015 Jan) |
25445822
|
2015 |
| Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of l ... | Radigan, Kathryn A; Morales-Nebreda, Luisa; Soberanes, Saul; Nicholson, Trevor; Nigdelioglu, Re ... | R01ES015024 | PLoS One (2014) |
25232724
|
2014 |
| Loss of TLR4 does not prevent influenza A-induced mortality. | Morales-Nebreda, Luisa; Mutlu, Gökhan M; Scott Budinger, G R; Radigan, Kathryn A | R01ES015024 | Am J Respir Crit Care Med (2014 May 15) |
24832747
|
2014 |
| Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. | Wheaton, William W; Weinberg, Samuel E; Hamanaka, Robert B; Soberanes, Saul; Sullivan, Lucas B; ... | R01ES015024 | Elife (2014 May 13) |
24843020
|
2014 |
| Promotion of lung health: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. | Camargo Jr, Carlos A; Budinger, G R Scott; Escobar, Gabriel J; Hansel, Nadia N; Hanson, Corrine ... | R01ES015024 | Ann Am Thorac Soc (2014 Apr) |
24754821
|
2014 |
| Reply: β2-agonists and acute respiratory distress syndrome. | Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | Am J Respir Crit Care Med (2014 Jun 1) |
24881949
|
2014 |
| β2-agonists and acute respiratory distress syndrome. | Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | Am J Respir Crit Care Med (2014 Mar 15) |
24628310
|
2014 |
| β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. | Chiarella, Sergio E; Soberanes, Saul; Urich, Daniela; Morales-Nebreda, Luisa; Nigdelioglu, Rece ... | R01ES015024 | J Clin Invest (2014 Jul) |
24865431
|
2014 |
| Balancing the risks and benefits of oxygen therapy in critically III adults. | Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | Chest (2013 Apr) |
23546490
|
2013 |
| Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. | Misharin, Alexander V; Morales-Nebreda, Luisa; Mutlu, Gökhan M; Budinger, G R Scott; Perlman, H ... | R01ES015024 | Am J Respir Cell Mol Biol (2013 Oct) |
23672262
|
2013 |
| Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. | Do-Umehara, Hanh Chi; Chen, Cong; Urich, Daniela; Zhou, Liang; Qiu, Ju; Jang, Samuel; Zander, ... | R01ES015024 | Nat Immunol (2013 May) |
23525087
|
2013 |
| Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 r ... | Dada, Laura; Gonzalez, Angel R; Urich, Daniela; Soberanes, Saul; Manghi, Tomas S; Chiarella, S ... | R01ES015024 | PLoS One (2012) |
22272351
|
2012 |
| Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial RO ... | Soberanes, Saul; Gonzalez, Angel; Urich, Daniela; Chiarella, Sergio E; Radigan, Kathryn A; Osor ... | R01ES015024 | Sci Rep (2012) |
22355787
|
2012 |
| Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling. | Mutlu, Gökhan M; Budinger, G R Scott; Wu, Minghua; Lam, Anna P; Zirk, Aaron; Rivera, Stephanie ... | R01ES015024 | Thorax (2012 Feb) |
21921091
|
2012 |
| The effect of rosuvastatin in a murine model of influenza A infection. | Radigan, Kathryn A; Urich, Daniela; Misharin, Alexander V; Chiarella, Sergio E; Soberanes, Saul ... | R01ES015024 | PLoS One (2012) |
22536437
|
2012 |
| Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. | Budinger, G R Scott; Mutlu, Gökhan M; Urich, Daniela; Soberanes, Saul; Buccellato, Leonard J; H ... | R01ES015024 | Am J Respir Crit Care Med (2011 Apr 15) |
20959557
|
2011 |
| Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome prol ... | Jain, Manu; Budinger, G R Scott; Lo, Amy; Urich, Daniela; Rivera, Stephanie E; Ghosh, Asish K; ... | R01ES015024 | Am J Respir Crit Care Med (2011 Jun 01) |
21317313
|
2011 |
| Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury. | Urich, Daniela; Eisenberg, Jessica L; Hamill, Kevin J; Takawira, Desire; Chiarella, Sergio E; S ... | R01ES015024 | J Cell Sci (2011 Sep 01) |
21878500
|
2011 |
| Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in th ... | Duch, Matthew C; Budinger, G R Scott; Liang, Yu Teng; Soberanes, Saul; Urich, Daniela; Chiarell ... | R01ES015024 | Nano Lett (2011 Dec 14) |
22023654
|
2011 |
| Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast ... | Lam, Anna P; Flozak, Annette S; Russell, Susan; Wei, Jun; Jain, Manu; Mutlu, Gökhan M; Budinge ... | R01ES015024 | Am J Respir Cell Mol Biol (2011 Nov) |
21454805
|
2011 |
| Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. | Mutlu, Ece A; Engen, Phillip A; Soberanes, Saul; Urich, Daniela; Forsyth, Christopher B; Nigdel ... | R01ES015024 | Part Fibre Toxicol (2011 Jun 09) |
21658250
|
2011 |
| Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagul ... | Budinger, G R Scott; McKell, Joanne L; Urich, Daniela; Foiles, Nancy; Weiss, Ivy; Chiarella, S ... | R01ES015024 | PLoS One (2011 Apr 11) |
21494547
|
2011 |
| The lung macrophage: a Jack of all trades. | Misharin, Alexander V; Scott Budinger, G R; Perlman, Harris | R01ES015024 | Am J Respir Crit Care Med (2011 Sep 01) |
21885631
|
2011 |
| Update in environmental and occupational medicine 2010. | Budinger, G R Scott; Mutlu, Gokhan M | R01ES015024 | Am J Respir Crit Care Med (2011 Jun 15) |
21693716
|
2011 |
| Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and m ... | Flozak, Annette S; Lam, Anna P; Russell, Susan; Jain, Manu; Peled, Ofra N; Sheppard, Kerry A; ... | R01ES015024 | J Biol Chem (2010 Jan 29) |
19933277
|
2010 |
| Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary tox ... | Mutlu, Gökhan M; Budinger, G R Scott; Green, Alexander A; Urich, Daniela; Soberanes, Saul; Chia ... | R01ES015024 | Nano Lett (2010 May 12) |
20377197
|
2010 |
| Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. | Weinberg, Frank; Hamanaka, Robert; Wheaton, William W; Weinberg, Samuel; Joseph, Joy; Lopez, M ... | R01ES015024 | Proc Natl Acad Sci U S A (2010 May 11) |
20421486
|
2010 |
| Update in environmental and occupational medicine 2009. | Van Hee, Victor C; Kaufman, Joel D; Budinger, G R Scott; Mutlu, Gokhan M | P30ES007033, R01ES015024 | Am J Respir Crit Care Med (2010 Jun 1) |
20516491
|
2010 |
| Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cel ... | Soberanes, Saul; Urich, Daniela; Baker, Christina M; Burgess, Zach; Chiarella, Sergio E; Bell, ... | R01ES015024 | J Biol Chem (2009 Jan 23) |
19033436
|
2009 |
| Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. | Urich, Daniela; Soberanes, Saul; Burgess, Zach; Chiarella, Sergio E; Ghio, Andrew J; Ridge, Ka ... | R01ES015024 | FASEB J (2009 Jul) |
19237507
|
2009 |
| Alveolar epithelial beta2-adrenergic receptors. | Mutlu, Gokhan M; Factor, Phillip | R01ES015024 | Am J Respir Cell Mol Biol (2008 Feb) |
17709598
|
2008 |
| Stretch-induced activation of AMP kinase in the lung requires dystroglycan. | Budinger, G R Scott; Urich, Daniela; DeBiase, Phillip J; Chiarella, Sergio E; Burgess, Zachary ... | R01ES015024 | Am J Respir Cell Mol Biol (2008 Dec) |
18556591
|
2008 |
| Adenosine regulation of alveolar fluid clearance. | Factor, Phillip; Mutlu, Goskhan M; Chen, Lan; Mohameed, Jameel; Akhmedov, Alexander T; Meng, F ... | R01ES015024 | Proc Natl Acad Sci U S A (2007 Mar 6) |
17360481
|
2007 |
| Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. | Mutlu, Gökhan M; Green, David; Bellmeyer, Amy; Baker, Christina M; Burgess, Zach; Rajamannan, ... | R01ES015024 | J Clin Invest (2007 Oct) |
17885684
|
2007 |
| Leptin resistance protects mice from hyperoxia-induced acute lung injury. | Bellmeyer, Amy; Martino, Janice M; Chandel, Navdeep S; Scott Budinger, G R; Dean, David A; Mutl ... | R01ES015024 | Am J Respir Crit Care Med (2007 Mar 15) |
17185651
|
2007 |
| The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell dea ... | Wang, Helena L; Akinci, I Ozkan; Baker, Christina M; Urich, Daniela; Bellmeyer, Amy; Jain, Man ... | R01ES015024 | J Immunol (2007 Aug 01) |
17641050
|
2007 |