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Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: ROLE OF ALVEOLAR MACROPHAGES IN PARTICULATE MATTER-INDUCED CARDIOPULMONARY DISEASE
PI: Mutlu, Gokhan M.
Institution: University Of Chicago
Grant Number: R01ES015024

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 60 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES015024/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism.   Hamanaka, Robert B; Mutlu, Gökhan M P30ES027792, R01ES015024, U01ES026718 FEBS J (2021 Jan 03) 33393204 Exiting the NIEHS site 2021 
Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory ...   Sun, Kaitlyn A; Li, Yan; Meliton, Angelo Y; Woods, Parker S; Kimmig, Lucas M; Cetin-Atalay, Re ... P30ES027792, R01ES015024, U01ES026718 Elife (2020 04 07) 32255424 Exiting the NIEHS site 2020 
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.   Woods, Parker S; Kimmig, Lucas M; Meliton, Angelo Y; Sun, Kaitlyn A; Tian, Yufeng; O'Leary, Er ... P30ES027792, R01ES015024, U01ES026718 Am J Respir Cell Mol Biol (2020 02) 31469581 Exiting the NIEHS site 2020 
Air Pollution, Asthma, and Sleep Apnea: New Epidemiological Links?   Mutlu, Gökhan M; Peker, Yüksel P30ES027792, R01ES015024, U01ES026718 Ann Am Thorac Soc (2019 Mar) 31339334 Exiting the NIEHS site 2019 
Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury.   Hamanaka, Robert B; Mutlu, Gökhan M R01ES015024 Am J Respir Cell Mol Biol (2019 02) 30278142 Exiting the NIEHS site 2019 
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.   Hamanaka, Robert B; O'Leary, Erin M; Witt, Leah J; Tian, Yufeng; Gökalp, Gizem A; Meliton, Ang ... P30ES027792, R01ES015024, U01ES026718 Am J Respir Cell Mol Biol (2019 11) 30973753 Exiting the NIEHS site 2019 
Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.   Soberanes, Saul; Misharin, Alexander V; Jairaman, Amit; Morales-Nebreda, Luisa; McQuattie-Piment ... P30ES027792, R01ES015024, U01ES026718 Cell Metab (2019 02 05) 30318339 Exiting the NIEHS site 2019 
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmona ...   Reyfman, Paul A; Walter, James M; Joshi, Nikita; Anekalla, Kishore R; McQuattie-Pimentel, Alexa ... R01ES015024 Am J Respir Crit Care Med (2019 06 15) 30554520 Exiting the NIEHS site 2019 
Inhalational exposure to particulate matter air pollution alters the composition of the gut microbio ...   Mutlu, Ece A; Comba, Işın Y; Cho, Takugo; Engen, Phillip A; Yazıcı, Cemal; Soberanes, Saul; Ha ... R01ES015024, U01ES026718 Environ Pollut (2018 Sep) 29783199 Exiting the NIEHS site 2018 
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.   Hamanaka, Robert B; Nigdelioglu, Recep; Meliton, Angelo Y; Tian, Yufeng; Witt, Leah J; O'Leary, ... R01ES015024 Am J Respir Cell Mol Biol (2018 05) 29019702 Exiting the NIEHS site 2018 
Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Leve ...   Mutlu, Gökhan M; Budinger, G R Scott R01ES015024 Circulation (2018 03 13) 29530899 Exiting the NIEHS site 2018 
Particulate Matter Air Pollution: Effects on the Cardiovascular System.   Hamanaka, Robert B; Mutlu, Gökhan M P30ES027792, R01ES015024, U01ES026718 Front Endocrinol (Lausanne) (2018) 30505291 Exiting the NIEHS site 2018 
Role of Cellular Metabolism in Pulmonary Diseases.   Wu, David; Woods, Parker S; Duong, Heng T; Mutlu, Gökhan M R01ES015024 Am J Respir Cell Mol Biol (2018 07) 29634283 Exiting the NIEHS site 2018 
Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regu ...   Huang, Ru-Ting; Wu, David; Meliton, Angelo; Oh, Myung-Jin; Krause, Matthew; Lloyd, Joyce A; Ni ... R01ES015024 Am J Respir Crit Care Med (2017 03 01) 27855271 Exiting the NIEHS site 2017 
HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular ...   Wu, David; Huang, Ru-Ting; Hamanaka, Robert B; Krause, Matt; Oh, Myung-Jin; Kuo, Cheng-Hsiang; ... R01ES015024 Elife (2017 05 30) 28556776 Exiting the NIEHS site 2017 
Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1α Drives E ...   Wu, David; Hamanaka, Robert B; Fang, Yun; Mutlu, Gökhan M R01ES015024 Arterioscler Thromb Vasc Biol (2017 12) 29162600 Exiting the NIEHS site 2017 
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span ...   Misharin, Alexander V; Morales-Nebreda, Luisa; Reyfman, Paul A; Cuda, Carla M; Walter, James M; ... R01ES015024 J Exp Med (2017 Aug 07) 28694385 Exiting the NIEHS site 2017 
PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epider ...   Hamanaka, Robert B; Mutlu, Gökhan M R01ES015024 J Invest Dermatol (2017 06) 28108301 Exiting the NIEHS site 2017 
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.   Peteranderl, Christin; Morales-Nebreda, Luisa; Selvakumar, Balachandar; Lecuona, Emilia; Vadász, ... R01ES015024 J Clin Invest (2016 Apr 01) 26999599 Exiting the NIEHS site 2016 
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.   Nigdelioglu, Recep; Hamanaka, Robert B; Meliton, Angelo Y; O'Leary, Erin; Witt, Leah J; Cho, T ... R01ES015024 J Biol Chem (2016 12 30) 27836973 Exiting the NIEHS site 2016 
Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans.   Bharat, Ankit; Cunningham, Scott A; Scott Budinger, G R; Kreisel, Daniel; DeWet, Charl J; Gelma ... R01ES015024 Sci Transl Med (2015 Apr 22) 25904745 Exiting the NIEHS site 2015 
Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.   Morales-Nebreda, Luisa I; Rogel, Micah R; Eisenberg, Jessica L; Hamill, Kevin J; Soberanes, Sau ... R01ES015024 Am J Respir Cell Mol Biol (2015 Apr) 25188360 Exiting the NIEHS site 2015 
Muscle dysfunction in patients with lung diseases: a growing epidemic.   Barreiro, Esther; Sznajder, Jacob I; Nader, Gustavo A; Budinger, G R Scott R01ES015024 Am J Respir Crit Care Med (2015 Mar 15) 25767924 Exiting the NIEHS site 2015 
Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect.   Ghio, Andrew J; Soukup, Joleen M; Dailey, Lisa A; Tong, Haiyan; Kesic, Matthew J; Budinger, G ... R01ES015024 Chem Res Toxicol (2015 Nov 16) 26462088 Exiting the NIEHS site 2015 
β₂-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe ...   Chiarella, Sergio E; Budinger, G R Scott; Mutlu, Gökhan M R01ES015024 J Allergy Clin Immunol (2015 Jan) 25445822 Exiting the NIEHS site 2015 
Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of l ...   Radigan, Kathryn A; Morales-Nebreda, Luisa; Soberanes, Saul; Nicholson, Trevor; Nigdelioglu, Re ... R01ES015024 PLoS One (2014) 25232724 Exiting the NIEHS site 2014 
Loss of TLR4 does not prevent influenza A-induced mortality.   Morales-Nebreda, Luisa; Mutlu, Gökhan M; Scott Budinger, G R; Radigan, Kathryn A R01ES015024 Am J Respir Crit Care Med (2014 May 15) 24832747 Exiting the NIEHS site 2014 
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.   Wheaton, William W; Weinberg, Samuel E; Hamanaka, Robert B; Soberanes, Saul; Sullivan, Lucas B; ... R01ES015024 Elife (2014 May 13) 24843020 Exiting the NIEHS site 2014 
Promotion of lung health: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.   Camargo Jr, Carlos A; Budinger, G R Scott; Escobar, Gabriel J; Hansel, Nadia N; Hanson, Corrine ... R01ES015024 Ann Am Thorac Soc (2014 Apr) 24754821 Exiting the NIEHS site 2014 
Reply: β2-agonists and acute respiratory distress syndrome.   Budinger, G R Scott; Mutlu, Gökhan M R01ES015024 Am J Respir Crit Care Med (2014 Jun 1) 24881949 Exiting the NIEHS site 2014 
β2-agonists and acute respiratory distress syndrome.   Budinger, G R Scott; Mutlu, Gökhan M R01ES015024 Am J Respir Crit Care Med (2014 Mar 15) 24628310 Exiting the NIEHS site 2014 
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.   Chiarella, Sergio E; Soberanes, Saul; Urich, Daniela; Morales-Nebreda, Luisa; Nigdelioglu, Rece ... R01ES015024 J Clin Invest (2014 Jul) 24865431 Exiting the NIEHS site 2014 
Balancing the risks and benefits of oxygen therapy in critically III adults.   Budinger, G R Scott; Mutlu, Gökhan M R01ES015024 Chest (2013 Apr) 23546490 Exiting the NIEHS site 2013 
Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung.   Misharin, Alexander V; Morales-Nebreda, Luisa; Mutlu, Gökhan M; Budinger, G R Scott; Perlman, H ... R01ES015024 Am J Respir Cell Mol Biol (2013 Oct) 23672262 Exiting the NIEHS site 2013 
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.   Do-Umehara, Hanh Chi; Chen, Cong; Urich, Daniela; Zhou, Liang; Qiu, Ju; Jang, Samuel; Zander, ... R01ES015024 Nat Immunol (2013 May) 23525087 Exiting the NIEHS site 2013 
Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 r ...   Dada, Laura; Gonzalez, Angel R; Urich, Daniela; Soberanes, Saul; Manghi, Tomas S; Chiarella, S ... R01ES015024 PLoS One (2012) 22272351 Exiting the NIEHS site 2012 
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial RO ...   Soberanes, Saul; Gonzalez, Angel; Urich, Daniela; Chiarella, Sergio E; Radigan, Kathryn A; Osor ... R01ES015024 Sci Rep (2012) 22355787 Exiting the NIEHS site 2012 
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.   Mutlu, Gökhan M; Budinger, G R Scott; Wu, Minghua; Lam, Anna P; Zirk, Aaron; Rivera, Stephanie ... R01ES015024 Thorax (2012 Feb) 21921091 Exiting the NIEHS site 2012 
The effect of rosuvastatin in a murine model of influenza A infection.   Radigan, Kathryn A; Urich, Daniela; Misharin, Alexander V; Chiarella, Sergio E; Soberanes, Saul ... R01ES015024 PLoS One (2012) 22536437 Exiting the NIEHS site 2012 
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.   Budinger, G R Scott; Mutlu, Gökhan M; Urich, Daniela; Soberanes, Saul; Buccellato, Leonard J; H ... R01ES015024 Am J Respir Crit Care Med (2011 Apr 15) 20959557 Exiting the NIEHS site 2011 
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome prol ...   Jain, Manu; Budinger, G R Scott; Lo, Amy; Urich, Daniela; Rivera, Stephanie E; Ghosh, Asish K; ... R01ES015024 Am J Respir Crit Care Med (2011 Jun 1) 21317313 Exiting the NIEHS site 2011 
Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.   Urich, Daniela; Eisenberg, Jessica L; Hamill, Kevin J; Takawira, Desire; Chiarella, Sergio E; S ... R01ES015024 J Cell Sci (2011 Sep 01) 21878500 Exiting the NIEHS site 2011 
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in th ...   Duch, Matthew C; Budinger, G R Scott; Liang, Yu Teng; Soberanes, Saul; Urich, Daniela; Chiarell ... R01ES015024 Nano Lett (2011 Dec 14) 22023654 Exiting the NIEHS site 2011 
Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast ...   Lam, Anna P; Flozak, Annette S; Russell, Susan; Wei, Jun; Jain, Manu; Mutlu, Gökhan M; Budinge ... R01ES015024 Am J Respir Cell Mol Biol (2011 Nov) 21454805 Exiting the NIEHS site 2011 
Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice.   Mutlu, Ece A; Engen, Phillip A; Soberanes, Saul; Urich, Daniela; Forsyth, Christopher B; Nigdel ... R01ES015024 Part Fibre Toxicol (2011) 21658250 Exiting the NIEHS site 2011 
Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagul ...   Budinger, G R Scott; McKell, Joanne L; Urich, Daniela; Foiles, Nancy; Weiss, Ivy; Chiarella, S ... R01ES015024 PLoS One (2011 Apr 11) 21494547 Exiting the NIEHS site 2011 
The lung macrophage: a Jack of all trades.   Misharin, Alexander V; Scott Budinger, G R; Perlman, Harris R01ES015024 Am J Respir Crit Care Med (2011 Sep 01) 21885631 Exiting the NIEHS site 2011 
Update in environmental and occupational medicine 2010.   Budinger, G R Scott; Mutlu, Gokhan M R01ES015024 Am J Respir Crit Care Med (2011 Jun 15) 21693716 Exiting the NIEHS site 2011 
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and m ...   Flozak, Annette S; Lam, Anna P; Russell, Susan; Jain, Manu; Peled, Ofra N; Sheppard, Kerry A; ... R01ES015024 J Biol Chem (2010 Jan 29) 19933277 Exiting the NIEHS site 2010 
Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary tox ...   Mutlu, Gökhan M; Budinger, G R Scott; Green, Alexander A; Urich, Daniela; Soberanes, Saul; Chia ... R01ES015024 Nano Lett (2010 May 12) 20377197 Exiting the NIEHS site 2010 
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.   Weinberg, Frank; Hamanaka, Robert; Wheaton, William W; Weinberg, Samuel; Joseph, Joy; Lopez, M ... R01ES015024 Proc Natl Acad Sci U S A (2010 May 11) 20421486 Exiting the NIEHS site 2010 
Update in environmental and occupational medicine 2009.   Van Hee, Victor C; Kaufman, Joel D; Budinger, G R Scott; Mutlu, Gokhan M P30ES007033, R01ES015024 Am J Respir Crit Care Med (2010 Jun 1) 20516491 Exiting the NIEHS site 2010 
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cel ...   Soberanes, Saul; Urich, Daniela; Baker, Christina M; Burgess, Zach; Chiarella, Sergio E; Bell, ... R01ES015024 J Biol Chem (2009 Jan 23) 19033436 Exiting the NIEHS site 2009 
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.   Urich, Daniela; Soberanes, Saul; Burgess, Zach; Chiarella, Sergio E; Ghio, Andrew J; Ridge, Ka ... R01ES015024 FASEB J (2009 Jul) 19237507 Exiting the NIEHS site 2009 
Alveolar epithelial beta2-adrenergic receptors.   Mutlu, Gokhan M; Factor, Phillip R01ES015024 Am J Respir Cell Mol Biol (2008 Feb) 17709598 Exiting the NIEHS site 2008 
Stretch-induced activation of AMP kinase in the lung requires dystroglycan.   Budinger, G R Scott; Urich, Daniela; DeBiase, Phillip J; Chiarella, Sergio E; Burgess, Zachary ... R01ES015024 Am J Respir Cell Mol Biol (2008 Dec) 18556591 Exiting the NIEHS site 2008 
Adenosine regulation of alveolar fluid clearance.   Factor, Phillip; Mutlu, Goskhan M; Chen, Lan; Mohameed, Jameel; Akhmedov, Alexander T; Meng, F ... R01ES015024 Proc Natl Acad Sci U S A (2007 Mar 6) 17360481 Exiting the NIEHS site 2007 
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.   Mutlu, Gökhan M; Green, David; Bellmeyer, Amy; Baker, Christina M; Burgess, Zach; Rajamannan, ... R01ES015024 J Clin Invest (2007 Oct) 17885684 Exiting the NIEHS site 2007 
Leptin resistance protects mice from hyperoxia-induced acute lung injury.   Bellmeyer, Amy; Martino, Janice M; Chandel, Navdeep S; Scott Budinger, G R; Dean, David A; Mutl ... R01ES015024 Am J Respir Crit Care Med (2007 Mar 15) 17185651 Exiting the NIEHS site 2007 
The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell dea ...   Wang, Helena L; Akinci, I Ozkan; Baker, Christina M; Urich, Daniela; Bellmeyer, Amy; Jain, Man ... R01ES015024 J Immunol (2007 Aug 01) 17641050 Exiting the NIEHS site 2007 
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