| Project Title: | REGULATION OF THE DNA DAMAGE RESPONSE |
|---|---|
| PI: | Cimprich, Karlene A |
| Institution: | Stanford University |
| Grant Number: | R01ES016486 |
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| ATR activity controls stem cell quiescence via the cyclin F-SCF complex. | Salvi, Jayesh S; Kang, Jengmin; Kim, Soochi; Colville, Alex J; de Morrée, Antoine; Billeskov, ... | R01ES016486 | Proc Natl Acad Sci U S A (2022 May 03) |
35476521
|
2022 |
| Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-def ... | Mehibel, Manal; Xu, Yu; Li, Caiyun G; Moon, Eui Jung; Thakkar, Kaushik N; Diep, Anh N; Kim, R ... | R01ES016486 | J Clin Invest (2021 Jun 01) |
34060485
|
2021 |
| HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanis ... | Bai, Gongshi; Kermi, Chames; Stoy, Henriette; Schiltz, Carl J; Bacal, Julien; Zaino, Angela M; ... | R01ES016486 | Mol Cell (2020 Jun 18) |
32442397
|
2020 |
| A new mitotic activity comes into focus. | Saldivar, Joshua C; Cimprich, Karlene A | R01ES016486 | Science (2018 01 05) |
29302000
|
2018 |
| An intrinsic S/G2 checkpoint enforced by ATR. | Saldivar, Joshua C; Hamperl, Stephan; Bocek, Michael J; Chung, Mingyu; Bass, Thomas E; Cisneros ... | R01ES016486 | Science (2018 08 24) |
30139873
|
2018 |
| Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dyn ... | Daigh, Leighton H; Liu, Chad; Chung, Mingyu; Cimprich, Karlene A; Meyer, Tobias | R01ES016486 | Cell Syst (2018 07 25) |
29909278
|
2018 |
| The essential kinase ATR: ensuring faithful duplication of a challenging genome. | Saldivar, Joshua C; Cortez, David; Cimprich, Karlene A | R01ES016486 | Nat Rev Mol Cell Biol (2017 10) |
28811666
|
2017 |
| Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. | Hess, Gaelen T; Frésard, Laure; Han, Kyuho; Lee, Cameron H; Li, Amy; Cimprich, Karlene A; Mont ... | R01ES016486 | Nat Methods (2016 Dec) |
27798611
|
2016 |
| DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. | Slaats, Gisela G; Saldivar, Joshua C; Bacal, Julien; Zeman, Michelle K; Kile, Andrew C; Hynes, ... | R01ES016486 | J Clin Invest (2015 Sep) |
26301811
|
2015 |
| HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal. | Kile, Andrew C; Chavez, Diana A; Bacal, Julien; Eldirany, Sherif; Korzhnev, Dmitry M; Bezsonova ... | R01ES016486 | Mol Cell (2015 Jun 18) |
26051180
|
2015 |
| Causes and consequences of replication stress. | Zeman, Michelle K; Cimprich, Karlene A | R01ES016486 | Nat Cell Biol (2014 Jan) |
24366029
|
2014 |
| DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. | Zeman, Michelle K; Lin, Jia-Ren; Freire, Raimundo; Cimprich, Karlene A | R01ES016486 | J Cell Biol (2014 Jul 21) |
25023518
|
2014 |
| A role for the MRN complex in ATR activation via TOPBP1 recruitment. | Duursma, Anja M; Driscoll, Robert; Elias, Josh E; Cimprich, Karlene A | R01ES016486 | Mol Cell (2013 Apr 11) |
23582259
|
2013 |
| ATR phosphorylates SMARCAL1 to prevent replication fork collapse. | Couch, Frank B; Bansbach, Carol E; Driscoll, Robert; Luzwick, Jessica W; Glick, Gloria G; Bétou ... | R01ES016486, T32ES007028 | Genes Dev (2013 Jul 15) |
23873943
|
2013 |
| Cognitive function and breast cancer: promise and potential insights from functional brain imaging. | Reuter-Lorenz, Patricia A; Cimprich, Bernadine | R01ES016486 | Breast Cancer Res Treat (2013 Jan) |
23053652
|
2013 |
| NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopath ... | Choi, Hyo Jei Claudia; Lin, Jia-Ren; Vannier, Jean-Baptiste; Slaats, Gisela G; Kile, Andrew C; ... | R01ES016486 | Mol Cell (2013 Aug 22) |
23973373
|
2013 |
| PHD domain from human SHPRH. | Machado, Luciana E F; Pustovalova, Yulia; Kile, Andrew C; Pozhidaeva, Alexandra; Cimprich, Karl ... | R01ES016486 | J Biomol NMR (2013 Aug) |
23907177
|
2013 |
| A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. | Chen, Jia-Yun; Lin, Jia-Ren; Cimprich, Karlene A; Meyer, Tobias | R01ES016486 | Mol Cell (2012 Jan 27) |
22206868
|
2012 |
| Finally, polyubiquitinated PCNA gets recognized. | Zeman, Michelle K; Cimprich, Karlene A | R01ES016486 | Mol Cell (2012 Aug 10) |
22883622
|
2012 |
| SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repa ... | Lin, Jia-Ren; Zeman, Michelle K; Chen, Jia-Yun; Yee, Muh-Ching; Cimprich, Karlene A | R01ES016486 | Mol Cell (2011 Apr 22) |
21396873
|
2011 |
| Checkpoint recovery after DNA damage: a rolling stop for CDKs. | Duursma, Anja M; Cimprich, Karlene A | R01ES016486 | EMBO Rep (2010 Jun) |
20467435
|
2010 |
| Continued primer synthesis at stalled replication forks contributes to checkpoint activation. | Van, Christopher; Yan, Shan; Michael, W Matthew; Waga, Shou; Cimprich, Karlene A | R01ES016486 | J Cell Biol (2010 Apr 19) |
20385778
|
2010 |
| A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stabi ... | Paulsen, Renee D; Soni, Deena V; Wollman, Roy; Hahn, Angela T; Yee, Muh-Ching; Guan, Anna; Hes ... | R01ES016486 | Mol Cell (2009 Jul 31) |
19647519
|
2009 |
| DNA damage tolerance: when it's OK to make mistakes. | Chang, Debbie J; Cimprich, Karlene A | R01ES016486 | Nat Chem Biol (2009 Feb) |
19148176
|
2009 |
| HARPing on about the DNA damage response during replication. | Driscoll, Robert; Cimprich, Karlene A | R01ES016486 | Genes Dev (2009 Oct 15) |
19833762
|
2009 |
| Proliferating cell nuclear antigen uses two distinct modes to move along DNA. | Kochaniak, Anna B; Habuchi, Satoshi; Loparo, Joseph J; Chang, Debbie J; Cimprich, Karlene A; Wa ... | R01ES016486 | J Biol Chem (2009 Jun 26) |
19411704
|
2009 |
| ATR: an essential regulator of genome integrity. | Cimprich, Karlene A; Cortez, David | R01ES016486 | Nat Rev Mol Cell Biol (2008 Aug) |
18594563
|
2008 |
| Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. | Lupardus, Patrick J; Van, Christopher; Cimprich, Karlene A | R01ES016486 | Methods (2007 Feb) |
17189864
|
2007 |
| Probing ATR activation with model DNA templates. | Cimprich, Karlene A | R01ES016486 | Cell Cycle (2007 Oct 01) |
17700074
|
2007 |
| The ATR pathway: fine-tuning the fork. | Paulsen, Renee D; Cimprich, Karlene A | R01ES016486 | DNA Repair (Amst) (2007 Jul 01) |
17531546
|
2007 |
| The structural determinants of checkpoint activation. | MacDougall, Christina A; Byun, Tony S; Van, Christopher; Yee, Muh-ching; Cimprich, Karlene A | R01ES016486 | Genes Dev (2007 Apr 15) |
17437996
|
2007 |
| Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires unc ... | Chang, Debbie J; Lupardus, Patrick J; Cimprich, Karlene A | R01ES016486 | J Biol Chem (2006 Oct 27) |
16959771
|
2006 |