Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: REGULATION OF THE DNA DAMAGE RESPONSE
PI: Cimprich, Karlene A
Institution: Stanford University
Grant Number: R01ES016486

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 30 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES016486/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanis ...   Bai, Gongshi; Kermi, Chames; Stoy, Henriette; Schiltz, Carl J; Bacal, Julien; Zaino, Angela M; ... R01ES016486 Mol Cell (2020 06 18) 32442397 Exiting the NIEHS site 2020 
A new mitotic activity comes into focus.   Saldivar, Joshua C; Cimprich, Karlene A R01ES016486 Science (2018 01 05) 29302000 Exiting the NIEHS site 2018 
An intrinsic S/G2 checkpoint enforced by ATR.   Saldivar, Joshua C; Hamperl, Stephan; Bocek, Michael J; Chung, Mingyu; Bass, Thomas E; Cisneros ... R01ES016486 Science (2018 08 24) 30139873 Exiting the NIEHS site 2018 
Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dyn ...   Daigh, Leighton H; Liu, Chad; Chung, Mingyu; Cimprich, Karlene A; Meyer, Tobias R01ES016486 Cell Syst (2018 07 25) 29909278 Exiting the NIEHS site 2018 
The essential kinase ATR: ensuring faithful duplication of a challenging genome.   Saldivar, Joshua C; Cortez, David; Cimprich, Karlene A R01ES016486 Nat Rev Mol Cell Biol (2017 10) 28811666 Exiting the NIEHS site 2017 
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.   Hess, Gaelen T; Frésard, Laure; Han, Kyuho; Lee, Cameron H; Li, Amy; Cimprich, Karlene A; Mont ... R01ES016486 Nat Methods (2016 Dec) 27798611 Exiting the NIEHS site 2016 
DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome.   Slaats, Gisela G; Saldivar, Joshua C; Bacal, Julien; Zeman, Michelle K; Kile, Andrew C; Hynes, ... R01ES016486 J Clin Invest (2015 Sep) 26301811 Exiting the NIEHS site 2015 
HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.   Kile, Andrew C; Chavez, Diana A; Bacal, Julien; Eldirany, Sherif; Korzhnev, Dmitry M; Bezsonova ... R01ES016486 Mol Cell (2015 Jun 18) 26051180 Exiting the NIEHS site 2015 
Causes and consequences of replication stress.   Zeman, Michelle K; Cimprich, Karlene A R01ES016486 Nat Cell Biol (2014 Jan) 24366029 Exiting the NIEHS site 2014 
DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.   Zeman, Michelle K; Lin, Jia-Ren; Freire, Raimundo; Cimprich, Karlene A R01ES016486 J Cell Biol (2014 Jul 21) 25023518 Exiting the NIEHS site 2014 
A role for the MRN complex in ATR activation via TOPBP1 recruitment.   Duursma, Anja M; Driscoll, Robert; Elias, Josh E; Cimprich, Karlene A R01ES016486 Mol Cell (2013 Apr 11) 23582259 Exiting the NIEHS site 2013 
ATR phosphorylates SMARCAL1 to prevent replication fork collapse.   Couch, Frank B; Bansbach, Carol E; Driscoll, Robert; Luzwick, Jessica W; Glick, Gloria G; Bétou ... R01ES016486, T32ES007028 Genes Dev (2013 Jul 15) 23873943 Exiting the NIEHS site 2013 
Cognitive function and breast cancer: promise and potential insights from functional brain imaging.   Reuter-Lorenz, Patricia A; Cimprich, Bernadine R01ES016486 Breast Cancer Res Treat (2013 Jan) 23053652 Exiting the NIEHS site 2013 
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopath ...   Choi, Hyo Jei Claudia; Lin, Jia-Ren; Vannier, Jean-Baptiste; Slaats, Gisela G; Kile, Andrew C; ... R01ES016486 Mol Cell (2013 Aug 22) 23973373 Exiting the NIEHS site 2013 
PHD domain from human SHPRH.   Machado, Luciana E F; Pustovalova, Yulia; Kile, Andrew C; Pozhidaeva, Alexandra; Cimprich, Karl ... R01ES016486 J Biomol NMR (2013 Aug) 23907177 Exiting the NIEHS site 2013 
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision.   Chen, Jia-Yun; Lin, Jia-Ren; Cimprich, Karlene A; Meyer, Tobias R01ES016486 Mol Cell (2012 Jan 27) 22206868 Exiting the NIEHS site 2012 
Finally, polyubiquitinated PCNA gets recognized.   Zeman, Michelle K; Cimprich, Karlene A R01ES016486 Mol Cell (2012 Aug 10) 22883622 Exiting the NIEHS site 2012 
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repa ...   Lin, Jia-Ren; Zeman, Michelle K; Chen, Jia-Yun; Yee, Muh-Ching; Cimprich, Karlene A R01ES016486 Mol Cell (2011 Apr 22) 21396873 Exiting the NIEHS site 2011 
Checkpoint recovery after DNA damage: a rolling stop for CDKs.   Duursma, Anja M; Cimprich, Karlene A R01ES016486 EMBO Rep (2010 Jun) 20467435 Exiting the NIEHS site 2010 
Continued primer synthesis at stalled replication forks contributes to checkpoint activation.   Van, Christopher; Yan, Shan; Michael, W Matthew; Waga, Shou; Cimprich, Karlene A R01ES016486 J Cell Biol (2010 Apr 19) 20385778 Exiting the NIEHS site 2010 
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stabi ...   Paulsen, Renee D; Soni, Deena V; Wollman, Roy; Hahn, Angela T; Yee, Muh-Ching; Guan, Anna; Hes ... R01ES016486 Mol Cell (2009 Jul 31) 19647519 Exiting the NIEHS site 2009 
DNA damage tolerance: when it's OK to make mistakes.   Chang, Debbie J; Cimprich, Karlene A R01ES016486 Nat Chem Biol (2009 Feb) 19148176 Exiting the NIEHS site 2009 
HARPing on about the DNA damage response during replication.   Driscoll, Robert; Cimprich, Karlene A R01ES016486 Genes Dev (2009 Oct 15) 19833762 Exiting the NIEHS site 2009 
Proliferating cell nuclear antigen uses two distinct modes to move along DNA.   Kochaniak, Anna B; Habuchi, Satoshi; Loparo, Joseph J; Chang, Debbie J; Cimprich, Karlene A; Wa ... R01ES016486 J Biol Chem (2009 Jun 26) 19411704 Exiting the NIEHS site 2009 
ATR: an essential regulator of genome integrity.   Cimprich, Karlene A; Cortez, David R01ES016486 Nat Rev Mol Cell Biol (2008 Aug) 18594563 Exiting the NIEHS site 2008 
Analyzing the ATR-mediated checkpoint using Xenopus egg extracts.   Lupardus, Patrick J; Van, Christopher; Cimprich, Karlene A R01ES016486 Methods (2007 Feb) 17189864 Exiting the NIEHS site 2007 
Probing ATR activation with model DNA templates.   Cimprich, Karlene A R01ES016486 Cell Cycle (2007 Oct 01) 17700074 Exiting the NIEHS site 2007 
The ATR pathway: fine-tuning the fork.   Paulsen, Renee D; Cimprich, Karlene A R01ES016486 DNA Repair (Amst) (2007 Jul 01) 17531546 Exiting the NIEHS site 2007 
The structural determinants of checkpoint activation.   MacDougall, Christina A; Byun, Tony S; Van, Christopher; Yee, Muh-ching; Cimprich, Karlene A R01ES016486 Genes Dev (2007 Apr 15) 17437996 Exiting the NIEHS site 2007 
Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires unc ...   Chang, Debbie J; Lupardus, Patrick J; Cimprich, Karlene A R01ES016486 J Biol Chem (2006 Oct 27) 16959771 Exiting the NIEHS site 2006 
Back
to Top