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Who We Fund: Publication Detail

Project Title: NOVEL ANTI-FIBROTIC MECHANISMS IN CHEMICAL-INDUCED LIVER INJURY
PI: Luyendyk, James P
Institution: Michigan State University
Grant Number: R01ES017537

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 49 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES017537/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice.   Miszta, Adam; Kopec, Anna K; Pant, Asmita; Holle, Lori A; Byrnes, James R; Lawrence, Daniel A; ... R01ES017537 Blood (2020 05 07) 32315384 Exiting the NIEHS site 2020 
Hemostasis and Liver Regeneration.   Starlinger, Patrick; Luyendyk, James P; Groeneveld, Dafna J R01ES017537 Semin Thromb Hemost (2020 Sep) 32906177 Exiting the NIEHS site 2020 
Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transg ...   Poole, L G; Pant, A; Baker, K S; Kopec, A K; Cline-Fedewa, H M; Iismaa, S E; Flick, M J; Luye ... R01ES017537, T32ES007255 J Thromb Haemost (2019 01) 30415489 Exiting the NIEHS site 2019 
Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahe ...   Baker, Kevin S; Kopec, Anna K; Pant, Asmita; Poole, Lauren G; Cline-Fedewa, Holly; Ivkovich, D ... R01ES017537, T32ES007255 Arterioscler Thromb Vasc Biol (2019 10) 31412737 Exiting the NIEHS site 2019 
Endothelial force awakens a mechanism of portal hypertension: It's a neutrophil extracellular trap!   Groeneveld, Dafna J; Luyendyk, James P R01ES017537 J Thromb Haemost (2019 08) 31254323 Exiting the NIEHS site 2019 
The multifaceted role of fibrinogen in tissue injury and inflammation.   Luyendyk, James P; Schoenecker, Jonathan G; Flick, Matthew J R01ES017537 Blood (2019 02 07) 30523120 Exiting the NIEHS site 2019 
Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo.   Kopec, Anna K; Spada, Alfred P; Contreras, Patricia C; Mackman, Nigel; Luyendyk, James P R01ES017537 Toxicol Sci (2018 04 01) 29228388 Exiting the NIEHS site 2018 
Platelets as Modulators of Liver Diseases.   Lisman, Ton; Luyendyk, James P R01ES017537 Semin Thromb Hemost (2018 Mar) 28898899 Exiting the NIEHS site 2018 
Role of the blood coagulation cascade in hepatic fibrosis.   Pant, Asmita; Kopec, Anna K; Luyendyk, James P R01ES017537 Am J Physiol Gastrointest Liver Physiol (2018 08 01) 29723040 Exiting the NIEHS site 2018 
Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellul ...   Joshi, Nikita; Ray, Jessica L; Kopec, Anna K; Luyendyk, James P R01ES017537 J Biochem Mol Toxicol (2017 Jan) 27605088 Exiting the NIEHS site 2017 
Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis ...   Joshi, Nikita; Kopec, Anna K; Cline-Fedewa, Holly; Luyendyk, James P R01ES017537 Toxicology (2017 02 15) 28049044 Exiting the NIEHS site 2017 
Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice.   Poole, Lauren G; Massey, Veronica L; Siow, Deanna L; Torres-Gonzáles, Edilson; Warner, Nikole L ... R01ES017537, T32ES011564 Am J Respir Cell Mol Biol (2017 09) 28445073 Exiting the NIEHS site 2017 
Targeting Phospholipase D4 Attenuates Kidney Fibrosis.   Trivedi, Priyanka; Kumar, Ramya K; Iyer, Ashwin; Boswell, Sarah; Gerarduzzi, Casimiro; Dadhania ... R01ES017537, R01ES017543, R01ES017543 J Am Soc Nephrol (2017 Dec) 28814511 Exiting the NIEHS site 2017 
Thrombin promotes diet-induced obesity through fibrin-driven inflammation.   Kopec, Anna K; Abrahams, Sara R; Thornton, Sherry; Palumbo, Joseph S; Mullins, Eric S; Divanovi ... R01ES017537 J Clin Invest (2017 Aug 01) 28737512 Exiting the NIEHS site 2017 
Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis.   Ray, Jessica L; Kopec, Anna K; Joshi, Nikita; Cline-Fedewa, Holly; Lash, Lawrence H; Williams, ... R01ES017537 Toxicol Sci (2017 04 01) 28115651 Exiting the NIEHS site 2017 
Von Willebrand factor deficiency reduces liver fibrosis in mice.   Joshi, Nikita; Kopec, Anna K; Ray, Jessica L; Cline-Fedewa, Holly; Groeneveld, Dafna J; Lisman, ... R01ES017537 Toxicol Appl Pharmacol (2017 08 01) 28527913 Exiting the NIEHS site 2017 
Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.   Joshi, Nikita; Kopec, Anna K; Ray, Jessica L; Cline-Fedewa, Holly; Nawabi, Atta; Schmitt, Timo ... R01ES017537 Blood (2016 06 02) 26921287 Exiting the NIEHS site 2016 
From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) i ...   Nault, Rance; Fader, Kelly A; Kopec, Anna K; Harkema, Jack R; Zacharewski, Timothy R; Luyendyk, ... R01ES017537 Toxicol Sci (2016 12) 27613713 Exiting the NIEHS site 2016 
Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver ...   Rautou, Pierre-Emmanuel; Tatsumi, Kohei; Antoniak, Silvio; Owens 3rd, A Phillip; Sparkenbaugh, ... R01ES017537 J Hepatol (2016 Jan) 26325534 Exiting the NIEHS site 2016 
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathol ...   Joshi, Nikita; Kopec, Anna K; Ray, Jessica L; Luyendyk, James P R01ES017537 Toxicology (2016 07 15) 27475285 Exiting the NIEHS site 2016 
RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis.   Craciun, Florin L; Bijol, Vanesa; Ajay, Amrendra K; Rao, Poornima; Kumar, Ramya K; Hutchinson, ... R01ES017537, R01ES017543, R01ES017543 J Am Soc Nephrol (2016 06) 26449608 Exiting the NIEHS site 2016 
Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?   Kopec, Anna K; Luyendyk, James P R01ES017537 Semin Thromb Hemost (2016 Jun) 27144445 Exiting the NIEHS site 2016 
Role of hemostatic factors in hepatic injury and disease: animal models de-liver.   Kopec, A K; Joshi, N; Luyendyk, J P R01ES017537 J Thromb Haemost (2016 07) 27060337 Exiting the NIEHS site 2016 
A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic de ...   Ellery, Paul E R; Maroney, Susan A; Cooley, Brian C; Luyendyk, James P; Zogg, Mark; Weiler, Ha ... R01ES017537 Blood (2015 Jun 25) 25954015 Exiting the NIEHS site 2015 
Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.   Joshi, N; Kopec, A K; O'Brien, K M; Towery, K L; Cline-Fedewa, H; Williams, K J; Copple, B L; ... R01ES017537 J Thromb Haemost (2015 Jan) 25353084 Exiting the NIEHS site 2015 
Circulating microparticle tissue factor activity is increased in patients with cirrhosis.   Rautou, Pierre-Emmanuel; Vion, Anne-Clémence; Luyendyk, James P; Mackman, Nigel R01ES017537 Hepatology (2014 Nov) 24470301 Exiting the NIEHS site 2014 
Coagulation in liver toxicity and disease: role of hepatocyte tissue factor.   Kopec, Anna K; Luyendyk, James P R01ES017537 Thromb Res (2014 May) 24759146 Exiting the NIEHS site 2014 
Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo.   Lopez, Michelle; Kopec, Anna K; Joshi, Nikita; Geddings, Julia E; Cline, Holly; Towery, Keara ... R01ES017537 Toxicol Sci (2014 Oct) 25015658 Exiting the NIEHS site 2014 
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-depe ...   Mochizuki, Akie; Pace, Aaron; Rockwell, Cheryl E; Roth, Katherine J; Chow, Aaron; O'Brien, Kat ... R01ES017537, T32ES007255 J Immunol (2014 Apr 15) 24639359 Exiting the NIEHS site 2014 
Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy ...   Ni, Hong-Min; Woolbright, Benjamin L; Williams, Jessica; Copple, Bryan; Cui, Wei; Luyendyk, Ja ... R01ES017537 J Hepatol (2014 Sep) 24815875 Exiting the NIEHS site 2014 
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chro ...   Joshi, Nikita; Kopec, Anna K; Towery, Keara; Williams, Kurt J; Luyendyk, James P R01ES017537 J Pharmacol Exp Ther (2014 Jun) 24633426 Exiting the NIEHS site 2014 
Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mi ...   Kopec, Anna K; Joshi, Nikita; Towery, Keara L; Kassel, Karen M; Sullivan, Bradley P; Flick, Ma ... R01ES017537 J Pharmacol Exp Ther (2014 Nov) 25138021 Exiting the NIEHS site 2014 
Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cho ...   Kopec, Anna K; Sullivan, Bradley P; Kassel, Karen M; Joshi, Nikita; Luyendyk, James P R01ES017537 Toxicol Sci (2014 Oct) 25055964 Exiting the NIEHS site 2014 
Hepatocyte tissue factor activates the coagulation cascade in mice.   Sullivan, Bradley P; Kopec, Anna K; Joshi, Nikita; Cline, Holly; Brown, Juliette A; Bishop, St ... R01ES017537 Blood (2013 Mar 07) 23305736 Exiting the NIEHS site 2013 
IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis.   O'Brien, Kate M; Allen, Katryn M; Rockwell, Cheryl E; Towery, Keara; Luyendyk, James P; Copple, ... R01ES017537, T32ES007255 Am J Pathol (2013 Nov) 24012680 Exiting the NIEHS site 2013 
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis ...   Sullivan, Bradley P; Cui, Wei; Copple, Bryan L; Luyendyk, James P R01ES017537 Toxicol Sci (2012 Mar) 22094456 Exiting the NIEHS site 2012 
Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.   Sullivan, Bradley P; Kassel, Karen M; Jone, Alice; Flick, Matthew J; Luyendyk, James P R01ES017537 Am J Pathol (2012 Jun) 22507835 Exiting the NIEHS site 2012 
Lipopolysaccharide enhances transforming growth factor ýý1-induced platelet-derived growth factor-B ...   Kassel, Karen M; Sullivan, Bradley P; Luyendyk, James P R01ES017537 J Gastroenterol Hepatol (2012 Apr) 22004089 Exiting the NIEHS site 2012 
Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation ...   Kassel, Karen M; Sullivan, Bradley P; Cui, Wei; Copple, Bryan L; Luyendyk, James P R01ES017537 Am J Pathol (2012 Oct) 22841818 Exiting the NIEHS site 2012 
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocyte ...   Mei, Shuang; Ni, Hong-Min; Manley, Sharon; Bockus, Abigail; Kassel, Karen M; Luyendyk, James P ... R01ES017537 J Pharmacol Exp Ther (2011 Nov) 21856859 Exiting the NIEHS site 2011 
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a mod ...   Luyendyk, James P; Kassel, Karen M; Allen, Katryn; Guo, Grace L; Li, Guodong; Cantor, Glenn H; ... R01ES017537 Am J Pathol (2011 Mar) 21356363 Exiting the NIEHS site 2011 
Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosi ...   Kassel, Karen M; Owens 3rd, A Phillip; Rockwell, Cheryl E; Sullivan, Bradley P; Wang, Ruipeng; ... R01ES017537 Am J Pathol (2011 Nov) 21907177 Exiting the NIEHS site 2011 
Regulation of transforming growth factor-ýý1-dependent integrin ýý6 expression by p38 mitogen-activa ...   Sullivan, Bradley P; Kassel, Karen M; Manley, Sharon; Baker, Alyson K; Luyendyk, James P R01ES017537 J Pharmacol Exp Ther (2011 May) 21303922 Exiting the NIEHS site 2011 
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver in ...   Luyendyk, James P; Mackman, Nigel; Sullivan, Bradley P R01ES017537 Toxicol Sci (2011 Jan) 20974703 Exiting the NIEHS site 2011 
Steatosis DeLIVERs high-sensitivity C-reactive protein.   Luyendyk, James P; Guo, Grace L R01ES017537 Arterioscler Thromb Vasc Biol (2011 Aug) 21775769 Exiting the NIEHS site 2011 
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mic ...   Luyendyk, James P; Flanagan, Kevin C; Williams, C David; Jaeschke, Hartmut; Slusser, Joyce G; M ... R01ES017537 Toxicol Appl Pharmacol (2011 Feb 01) 21070799 Exiting the NIEHS site 2011 
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion ...   Sullivan, Bradley P; Wang, Ruipeng; Tawfik, Ossama; Luyendyk, James P R01ES017537 Toxicol Sci (2010 May) 20133375 Exiting the NIEHS site 2010 
The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by ...   Sullivan, Bradley P; Weinreb, Paul H; Violette, Shelia M; Luyendyk, James P R01ES017537 Am J Pathol (2010 Dec) 21037076 Exiting the NIEHS site 2010 
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic ...   Luyendyk, James P; Cantor, Glenn H; Kirchhofer, Daniel; Mackman, Nigel; Copple, Bryan L; Wang, ... R01ES017537 Am J Physiol Gastrointest Liver Physiol (2009 Apr) 19179621 Exiting the NIEHS site 2009 
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