Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: TOXICOLOGICAL IMPORTANCE OF CYP3A4 CATALYSIS AND INHIBITION
PI: Sevrioukova, Irina F
Institution: University Of California-Irvine
Grant Number: R01ES025767

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 14 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES025767/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2021 Jan 16) 33467005 Exiting the NIEHS site 2021 
An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors o ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Bioorg Med Chem (2020 03 15) 32044230 Exiting the NIEHS site 2020 
Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases.   Murarka, Vidhi C; Batabyal, Dipanwita; Amaya, Jose A; Sevrioukova, Irina F; Poulos, Thomas L R01ES025767 Biochemistry (2020 Jul 28) 32551522 Exiting the NIEHS site 2020 
Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution.   Chuo, Shih-Wei; Liou, Shu-Hao; Wang, Lee-Ping; Britt, R David; Poulos, Thomas L; Sevrioukova, ... R01ES025767 Biochemistry (2019 09 17) 31456404 Exiting the NIEHS site 2019 
Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules.   Sevrioukova, Irina R01ES025767 Biochemistry (2019 02 19) 30676743 Exiting the NIEHS site 2019 
Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deox ...   Chen, Yu-Jie; Zhang, Jian; Zhu, Ping-Ping; Tan, Xian-Wen; Lin, Qiu-Hong; Wang, Wen-Xia; Yin, ... R01ES025767 Drug Metab Dispos (2019 06) 30918015 Exiting the NIEHS site 2019 
Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, ...   Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2019 Aug 30) 31480231 Exiting the NIEHS site 2019 
Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group St ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Biochemistry (2019 04 16) 30912932 Exiting the NIEHS site 2019 
Direct Synthesis of α-Thio Aromatic Acids from Aromatic Amino Acids.   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Tetrahedron Lett (2018 Mar 21) 30140110 Exiting the NIEHS site 2018 
Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Mol Pharm (2018 01 02) 29232137 Exiting the NIEHS site 2018 
Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling ...   Polic, Vanja; Sevrioukova, Irina F; Auclair, Karine R01ES025767 Arch Biochem Biophys (2018 09 01) 29958895 Exiting the NIEHS site 2018 
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.   Guo, Zhijun; Sevrioukova, Irina F; Denisov, Ilia G; Zhang, Xia; Chiu, Ting-Lan; Thomas, Dafydd ... P30ES013508, R01ES025767 Cell Chem Biol (2017 Oct 19) 28919040 Exiting the NIEHS site 2017 
High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.   Sevrioukova, Irina F R01ES025767 Biochemistry (2017 06 20) 28590129 Exiting the NIEHS site 2017 
Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.   Sevrioukova, Irina F; Poulos, Thomas L R01ES025767 Proc Natl Acad Sci U S A (2017 01 17) 28031486 Exiting the NIEHS site 2017 
Back
to Top