| Project Title: | PROTEIN AGGREGATION AND INFLAMMASOME SIGNALING IN MANGANESE NEUROTOXICITY |
|---|---|
| PI: | Kanthasamy, Anumantha Gounder |
| Institution: | Iowa State University |
| Grant Number: | R01ES026892 |
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology. | Malovic, Emir; Ealy, Alyssa; Kanthasamy, Arthi; Kanthasamy, Anumantha G | R01ES025991, R01ES026892 | Toxicol Sci (2021 Feb 22) |
33616673
|
2021 |
| An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenes ... | Kondru, Naveen; Manne, Sireesha; Kokemuller, Robyn; Greenlee, Justin; Greenlee, M Heather West; ... | R01ES026892 | Sci Rep (2020 05 06) |
32376941
|
2020 |
| Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients. | Manne, Sireesha; Kondru, Naveen; Jin, Huajun; Serrano, Geidy E; Anantharam, Vellareddy; Kanthas ... | R01ES026892 | Mov Disord (2020 12) |
32960470
|
2020 |
| Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational res ... | Harischandra, Dilshan S; Rokad, Dharmin; Ghaisas, Shivani; Verma, Saurabh; Robertson, Alan; Jin ... | R01ES025991, R01ES026892 | Biochim Biophys Acta Mol Basis Dis (2020 04 01) |
31442530
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2020 |
| Enzyme Immunoassay-Based Platform for Accurate Detection of Serum Pathological α-Synuclein in Parkin ... | Schlichtmann, Benjamin W; Kondru, Naveen; Hepker, Monica M; Kanthasamy, Anumantha G; Anantharam, ... | R01ES026892 | ACS Chem Neurosci (2020 12 16) |
33196164
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2020 |
| Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translat ... | Saminathan, Hariharan; Charli, Adhithiya; Luo, Jie; Panicker, Nikhil; Gordon, Richard; Hostette ... | R01ES026892 | Eur J Pharmacol (2020 Aug 15) |
32565338
|
2020 |
| Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. | Sarkar, Souvarish; Nguyen, Hai M; Malovic, Emir; Luo, Jie; Langley, Monica; Palanisamy, Bharat ... | R01ES026892 | J Clin Invest (2020 08 03) |
32597830
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2020 |
| Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells. | Sarkar, Souvarish; Dammer, Eric B; Malovic, Emir; Olsen, Abby L; Raza, Syed Ali; Gao, Tianwen; ... | R01ES026892 | Front Immunol (2020) |
32082315
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2020 |
| Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain in ... | Désaubry, Laurent; Kanthasamy, Anumantha G; Nebigil, Canan G | R01ES026892 | Pharmacol Res (2020 10) |
32937177
|
2020 |
| α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease ... | Manne, Sireesha; Kondru, Naveen; Jin, Huajun; Anantharam, Vellareddy; Huang, Xuemei; Kanthasamy ... | R01ES026892 | Mov Disord (2020 02) |
31758740
|
2020 |
| Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neu ... | Kanthasamy, Arthi; Jin, Huajun; Charli, Adhithiya; Vellareddy, Anantharam; Kanthasamy, Anumanth ... | R01ES026892, R01ES027245 | Pharmacol Ther (2019 05) |
30677475
|
2019 |
| Exosomes as Mediators of Chemical-Induced Toxicity. | Rokad, Dharmin; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Kanthasamy, Anumantha G | R01ES025991, R01ES026892 | Curr Environ Health Rep (2019 09) |
31102182
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2019 |
| Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease. | Panicker, Nikhil; Kanthasamy, Arthi; Kanthasamy, Anumantha G | R01ES026892 | Aging (Albany NY) (2019 08 27) |
31454793
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2019 |
| Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. | Panicker, Nikhil; Sarkar, Souvarish; Harischandra, Dilshan S; Neal, Matthew; Kam, Tae-In; Jin, ... | R01ES026892 | J Exp Med (2019 06 03) |
31036561
|
2019 |
| HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammatio ... | Massey, Nyzil; Puttachary, Sreekanth; Bhat, Sanjana Mahadev; Kanthasamy, Anumantha G; Charavarya ... | R01ES026892, R01ES027245 | Toxicol Sci (2019 06 01) |
30859215
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2019 |
| Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglia ... | Sarkar, Souvarish; Rokad, Dharmin; Malovic, Emir; Luo, Jie; Harischandra, Dilshan S; Jin, Huaj ... | R01ES019672, R01ES026892 | Sci Signal (2019 01 08) |
30622196
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2019 |
| Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. | Harischandra, Dilshan S; Rokad, Dharmin; Neal, Matthew L; Ghaisas, Shivani; Manne, Sireesha; Sa ... | R01ES025991, R01ES026892 | Sci Signal (2019 03 12) |
30862700
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2019 |
| Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic N ... | Song, Chunjuan; Charli, Adhithiya; Luo, Jie; Riaz, Zainab; Jin, Huajun; Anantharam, Vellareddy ... | R01ES026892, R01ES027245 | Toxicol Sci (2019 06 01) |
30796443
|
2019 |
| MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome ch ... | Ghaisas, Shivani; Langley, Monica R; Palanisamy, Bharathi N; Dutta, Somak; Narayanaswamy, Kirth ... | R01ES026892, R01ES027245 | Neurotoxicology (2019 12) |
31505196
|
2019 |
| Neurotoxicity of pesticides. | Richardson, Jason R; Fitsanakis, Vanessa; Westerink, Remco H S; Kanthasamy, Anumantha G | R01ES024288, R01ES026057, R01ES026892, R01ES027245 | Acta Neuropathol (2019 09) |
31197504
|
2019 |
| Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Br ... | Manne, Sireesha; Kondru, Naveen; Hepker, Monica; Jin, Huajun; Anantharam, Vellareddy; Lewis, M ... | R01ES026892 | J Neuroimmune Pharmacol (2019 09) |
30706414
|
2019 |
| Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacolog ... | Luo, Jie; Padhi, Piyush; Jin, Huajun; Anantharam, Vellareddy; Zenitsky, Gary; Wang, Qian; Will ... | R01ES026892, R01ES027245 | J Neuroimmune Pharmacol (2019 12) |
30879240
|
2019 |
| Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinf ... | Sarkar, Souvarish; Malovic, Emir; Sarda, Deeksha; Lawana, Vivek; Rokad, Dharmin; Jin, Huajun; ... | R01ES026892 | Neurotoxicology (2018 07) |
29775624
|
2018 |
| Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell cultur ... | Harischandra, Dilshan S; Ghaisas, Shivani; Rokad, Dharmin; Zamanian, Mostafa; Jin, Huajun; Anan ... | R01ES026892 | Neurotoxicology (2018 01) |
28450057
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2018 |
| Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. | Gordon, Richard; Albornoz, Eduardo A; Christie, Daniel C; Langley, Monica R; Kumar, Vinod; Mant ... | R01ES026892 | Sci Transl Med (2018 10 31) |
30381407
|
2018 |
| Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mous ... | Langley, Monica R; Ghaisas, Shivani; Ay, Muhammet; Luo, Jie; Palanisamy, Bharathi N; Jin, Huaj ... | R01ES026892 | Neurotoxicology (2018 01) |
28595911
|
2018 |
| Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes. | Sarkar, Souvarish; Malovic, Emir; Harischandra, Dilshan S; Ngwa, Hilary A; Ghosh, Anamitra; Hog ... | R01ES026892 | Neurotoxicology (2018 01) |
28539244
|
2018 |
| Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. | Neal, Matthew; Luo, Jie; Harischandra, Dilshan S; Gordon, Richard; Sarkar, Souvarish; Jin, Hua ... | R01ES026892, R01ES027245 | Glia (2018 10) |
30277602
|
2018 |
| Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues fr ... | Manne, Sireesha; Kondru, Naveen; Nichols, Tracy; Lehmkuhl, Aaron; Thomsen, Bruce; Main, Rodger ... | R01ES026892 | Prion (2017 11 02) |
29098931
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2017 |
| Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Di ... | Harischandra, Dilshan S; Ghaisas, Shivani; Rokad, Dharmin; Kanthasamy, Anumantha G | R01ES026892 | Toxicol Sci (2017 07 01) |
28505322
|
2017 |
| Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Disc ... | Kondru, Naveen; Manne, Sireesha; Greenlee, Justin; West Greenlee, Heather; Anantharam, Vellared ... | R01ES026892 | Sci Rep (2017 02 24) |
28233859
|
2017 |
| Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell ... | Sarkar, Souvarish; Malovic, Emir; Harishchandra, Dilshan S; Ghaisas, Shivani; Panicker, Nikhil; ... | R01ES026892, R01ES027245 | NPJ Parkinsons Dis (2017) |
29057315
|
2017 |
| Neurotoxicity of Vanadium. | Ngwa, Hilary Afeseh; Ay, Muhammet; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Kant ... | R01ES026892 | Adv Neurobiol (2017) |
28889273
|
2017 |
| Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility ... | Sarkar, Souvarish; Malovic, Emir; Plante, Brandon; Zenitsky, Gary; Jin, Huajun; Anantharam, Ve ... | R01ES026892 | J Vis Exp (2017 04 13) |
28447995
|
2017 |
| Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation. | Rokad, Dharmin; Ghaisas, Shivani; Harischandra, Dilshan S; Jin, Huajun; Anantharam, Vellareddy; ... | R01ES026892 | Brain Res Bull (2017 Jul) |
27993598
|
2017 |