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Who We Fund: Publication Detail

Project Title: PROTEIN AGGREGATION AND INFLAMMASOME SIGNALING IN MANGANESE NEUROTOXICITY
PI: Kanthasamy, Anumantha Gounder
Institution: Iowa State University
Grant Number: R01ES026892

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 35 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R01ES026892/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology.   Malovic, Emir; Ealy, Alyssa; Kanthasamy, Arthi; Kanthasamy, Anumantha G R01ES025991, R01ES026892 Toxicol Sci (2021 Feb 22) 33616673 Exiting the NIEHS site 2021 
An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenes ...   Kondru, Naveen; Manne, Sireesha; Kokemuller, Robyn; Greenlee, Justin; Greenlee, M Heather West; ... R01ES026892 Sci Rep (2020 05 06) 32376941 Exiting the NIEHS site 2020 
Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients.   Manne, Sireesha; Kondru, Naveen; Jin, Huajun; Serrano, Geidy E; Anantharam, Vellareddy; Kanthas ... R01ES026892 Mov Disord (2020 12) 32960470 Exiting the NIEHS site 2020 
Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational res ...   Harischandra, Dilshan S; Rokad, Dharmin; Ghaisas, Shivani; Verma, Saurabh; Robertson, Alan; Jin ... R01ES025991, R01ES026892 Biochim Biophys Acta Mol Basis Dis (2020 04 01) 31442530 Exiting the NIEHS site 2020 
Enzyme Immunoassay-Based Platform for Accurate Detection of Serum Pathological α-Synuclein in Parkin ...   Schlichtmann, Benjamin W; Kondru, Naveen; Hepker, Monica M; Kanthasamy, Anumantha G; Anantharam, ... R01ES026892 ACS Chem Neurosci (2020 12 16) 33196164 Exiting the NIEHS site 2020 
Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translat ...   Saminathan, Hariharan; Charli, Adhithiya; Luo, Jie; Panicker, Nikhil; Gordon, Richard; Hostette ... R01ES026892 Eur J Pharmacol (2020 Aug 15) 32565338 Exiting the NIEHS site 2020 
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.   Sarkar, Souvarish; Nguyen, Hai M; Malovic, Emir; Luo, Jie; Langley, Monica; Palanisamy, Bharat ... R01ES026892 J Clin Invest (2020 08 03) 32597830 Exiting the NIEHS site 2020 
Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.   Sarkar, Souvarish; Dammer, Eric B; Malovic, Emir; Olsen, Abby L; Raza, Syed Ali; Gao, Tianwen; ... R01ES026892 Front Immunol (2020) 32082315 Exiting the NIEHS site 2020 
Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain in ...   Désaubry, Laurent; Kanthasamy, Anumantha G; Nebigil, Canan G R01ES026892 Pharmacol Res (2020 10) 32937177 Exiting the NIEHS site 2020 
α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease ...   Manne, Sireesha; Kondru, Naveen; Jin, Huajun; Anantharam, Vellareddy; Huang, Xuemei; Kanthasamy ... R01ES026892 Mov Disord (2020 02) 31758740 Exiting the NIEHS site 2020 
Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neu ...   Kanthasamy, Arthi; Jin, Huajun; Charli, Adhithiya; Vellareddy, Anantharam; Kanthasamy, Anumanth ... R01ES026892, R01ES027245 Pharmacol Ther (2019 05) 30677475 Exiting the NIEHS site 2019 
Exosomes as Mediators of Chemical-Induced Toxicity.   Rokad, Dharmin; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Kanthasamy, Anumantha G R01ES025991, R01ES026892 Curr Environ Health Rep (2019 09) 31102182 Exiting the NIEHS site 2019 
Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease.   Panicker, Nikhil; Kanthasamy, Arthi; Kanthasamy, Anumantha G R01ES026892 Aging (Albany NY) (2019 08 27) 31454793 Exiting the NIEHS site 2019 
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.   Panicker, Nikhil; Sarkar, Souvarish; Harischandra, Dilshan S; Neal, Matthew; Kam, Tae-In; Jin, ... R01ES026892 J Exp Med (2019 06 03) 31036561 Exiting the NIEHS site 2019 
HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammatio ...   Massey, Nyzil; Puttachary, Sreekanth; Bhat, Sanjana Mahadev; Kanthasamy, Anumantha G; Charavarya ... R01ES026892, R01ES027245 Toxicol Sci (2019 06 01) 30859215 Exiting the NIEHS site 2019 
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglia ...   Sarkar, Souvarish; Rokad, Dharmin; Malovic, Emir; Luo, Jie; Harischandra, Dilshan S; Jin, Huaj ... R01ES019672, R01ES026892 Sci Signal (2019 01 08) 30622196 Exiting the NIEHS site 2019 
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.   Harischandra, Dilshan S; Rokad, Dharmin; Neal, Matthew L; Ghaisas, Shivani; Manne, Sireesha; Sa ... R01ES025991, R01ES026892 Sci Signal (2019 03 12) 30862700 Exiting the NIEHS site 2019 
Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic N ...   Song, Chunjuan; Charli, Adhithiya; Luo, Jie; Riaz, Zainab; Jin, Huajun; Anantharam, Vellareddy ... R01ES026892, R01ES027245 Toxicol Sci (2019 06 01) 30796443 Exiting the NIEHS site 2019 
MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome ch ...   Ghaisas, Shivani; Langley, Monica R; Palanisamy, Bharathi N; Dutta, Somak; Narayanaswamy, Kirth ... R01ES026892, R01ES027245 Neurotoxicology (2019 12) 31505196 Exiting the NIEHS site 2019 
Neurotoxicity of pesticides.   Richardson, Jason R; Fitsanakis, Vanessa; Westerink, Remco H S; Kanthasamy, Anumantha G R01ES024288, R01ES026057, R01ES026892, R01ES027245 Acta Neuropathol (2019 09) 31197504 Exiting the NIEHS site 2019 
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Br ...   Manne, Sireesha; Kondru, Naveen; Hepker, Monica; Jin, Huajun; Anantharam, Vellareddy; Lewis, M ... R01ES026892 J Neuroimmune Pharmacol (2019 09) 30706414 Exiting the NIEHS site 2019 
Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacolog ...   Luo, Jie; Padhi, Piyush; Jin, Huajun; Anantharam, Vellareddy; Zenitsky, Gary; Wang, Qian; Will ... R01ES026892, R01ES027245 J Neuroimmune Pharmacol (2019 12) 30879240 Exiting the NIEHS site 2019 
Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinf ...   Sarkar, Souvarish; Malovic, Emir; Sarda, Deeksha; Lawana, Vivek; Rokad, Dharmin; Jin, Huajun; ... R01ES026892 Neurotoxicology (2018 07) 29775624 Exiting the NIEHS site 2018 
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell cultur ...   Harischandra, Dilshan S; Ghaisas, Shivani; Rokad, Dharmin; Zamanian, Mostafa; Jin, Huajun; Anan ... R01ES026892 Neurotoxicology (2018 01) 28450057 Exiting the NIEHS site 2018 
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.   Gordon, Richard; Albornoz, Eduardo A; Christie, Daniel C; Langley, Monica R; Kumar, Vinod; Mant ... R01ES026892 Sci Transl Med (2018 10 31) 30381407 Exiting the NIEHS site 2018 
Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mous ...   Langley, Monica R; Ghaisas, Shivani; Ay, Muhammet; Luo, Jie; Palanisamy, Bharathi N; Jin, Huaj ... R01ES026892 Neurotoxicology (2018 01) 28595911 Exiting the NIEHS site 2018 
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.   Sarkar, Souvarish; Malovic, Emir; Harischandra, Dilshan S; Ngwa, Hilary A; Ghosh, Anamitra; Hog ... R01ES026892 Neurotoxicology (2018 01) 28539244 Exiting the NIEHS site 2018 
Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.   Neal, Matthew; Luo, Jie; Harischandra, Dilshan S; Gordon, Richard; Sarkar, Souvarish; Jin, Hua ... R01ES026892, R01ES027245 Glia (2018 10) 30277602 Exiting the NIEHS site 2018 
Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues fr ...   Manne, Sireesha; Kondru, Naveen; Nichols, Tracy; Lehmkuhl, Aaron; Thomsen, Bruce; Main, Rodger ... R01ES026892 Prion (2017 11 02) 29098931 Exiting the NIEHS site 2017 
Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Di ...   Harischandra, Dilshan S; Ghaisas, Shivani; Rokad, Dharmin; Kanthasamy, Anumantha G R01ES026892 Toxicol Sci (2017 07 01) 28505322 Exiting the NIEHS site 2017 
Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Disc ...   Kondru, Naveen; Manne, Sireesha; Greenlee, Justin; West Greenlee, Heather; Anantharam, Vellared ... R01ES026892 Sci Rep (2017 02 24) 28233859 Exiting the NIEHS site 2017 
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell ...   Sarkar, Souvarish; Malovic, Emir; Harishchandra, Dilshan S; Ghaisas, Shivani; Panicker, Nikhil; ... R01ES026892, R01ES027245 NPJ Parkinsons Dis (2017) 29057315 Exiting the NIEHS site 2017 
Neurotoxicity of Vanadium.   Ngwa, Hilary Afeseh; Ay, Muhammet; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Kant ... R01ES026892 Adv Neurobiol (2017) 28889273 Exiting the NIEHS site 2017 
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility ...   Sarkar, Souvarish; Malovic, Emir; Plante, Brandon; Zenitsky, Gary; Jin, Huajun; Anantharam, Ve ... R01ES026892 J Vis Exp (2017 04 13) 28447995 Exiting the NIEHS site 2017 
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.   Rokad, Dharmin; Ghaisas, Shivani; Harischandra, Dilshan S; Jin, Huajun; Anantharam, Vellareddy; ... R01ES026892 Brain Res Bull (2017 Jul) 27993598 Exiting the NIEHS site 2017 
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