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Who We Fund: Publication Detail

Project Title: CYP2B6 INHIBITORS PERTURB PROPER DISTRIBUTION OF LIPIDS LEADING TO OBESITY AND FATTY LIVER DISEASE
PI: Baldwin, William S
Institution: Clemson University
Grant Number: R15ES017321

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Viewing 38 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Increased Perfluorooctanesulfonate (PFOS) Toxicity and Accumulation Is Associated with Perturbed Pro ...   Williams, Lanie A; Hamilton, Matthew C; Edin, Matthew L; Lih, Fred B; Eccles-Miller, Jazmine A; ... R15ES017321 Toxics (2024 Jan 26) 38393201 Exiting the NIEHS site 2024 
Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acc ...   Heintz, Melissa M; Kumar, Ramiya; Maner-Smith, Kristal M; Ortlund, Eric A; Baldwin, William S R15ES017321 J Lipids (2022) 35391786 Exiting the NIEHS site 2022 
Dataset of endo- and xenobiotic inhibition of CYP2B6: Comparison to CYP3A4.   Olack, Emily M; Heintz, Melissa M; Baldwin, William S R15ES017321 Data Brief (2022 Apr) 35282180 Exiting the NIEHS site 2022 
Detoxification Cytochrome P450s (CYPs) in Families 1-3 Produce Functional Oxylipins from Polyunsatur ...   Eccles, Jazmine A; Baldwin, William S R15ES017321 Cells (2022 Dec 24) 36611876 Exiting the NIEHS site 2022 
The reproductive effects of the cancer chemotherapy agent, Carmofur, on Daphnia magna are mediated b ...   Gessner, Emily E; Shah, Manav H; Ghent, Bricen N; Westbrook, Nathaniel E; van den Hurk, Peter; ... R15ES017321 Ecotoxicology (2022 Jul) 35579761 Exiting the NIEHS site 2022 
Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic ...   Hamilton, Matthew C; Heintz, Melissa M; Pfohl, Marisa; Marques, Emily; Ford, Lucie; Slitt, Ang ... P42ES027706, R15ES017321 Food Chem Toxicol (2021 Jun) 33838175 Exiting the NIEHS site 2021 
20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms ca ...   Baldwin, William S; Bain, Lisa J; Di Giulio, Richard; Kullman, Seth; Rice, Charles D; Ringwood, ... R15ES017321 Aquat Toxicol (2020 Oct) 32932042 Exiting the NIEHS site 2020 
Gender differences in diet-induced steatotic disease in Cyp2b-null mice.   Heintz, Melissa M; McRee, Rebecca; Kumar, Ramiya; Baldwin, William S R15ES017321 PLoS One (2020) 32155178 Exiting the NIEHS site 2020 
Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced N ...   Rooney, John P; Oshida, Keiyu; Kumar, Ramiya; Baldwin, William S; Corton, J Christopher R15ES017321 Toxicol Sci (2019 01 01) 30203046 Exiting the NIEHS site 2019 
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.   Heintz, Melissa M; Kumar, Ramiya; Rutledge, Meredith M; Baldwin, William S R15ES017321 J Nutr Biochem (2019 08) 31202118 Exiting the NIEHS site 2019 
Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors as a First Ste ...   Baldwin, William S R15ES017321 Nucl Receptor Res (2019) 31815118 Exiting the NIEHS site 2019 
Cyp2b-Knockdown Mice Poorly Metabolize Corn Oil and Are Age-Dependent Obese.   Damiri, Basma; Baldwin, William S R15ES017321 Lipids (2018 09) 30421529 Exiting the NIEHS site 2018 
High fat diet induced obesity is mitigated in Cyp3a-null female mice.   Kumar, Ramiya; Litoff, Elizabeth J; Boswell, W Tyler; Baldwin, William S R15ES017321 Chem Biol Interact (2018 Jun 01) 29738703 Exiting the NIEHS site 2018 
Non-Mammalian Nuclear Receptors: From Evolution to Human Disease.   Gissendanner, Chris R; Baldwin, William S; Schaaf, Marcel J M R15ES017321 Nucl Receptor Res (2018) 30221173 Exiting the NIEHS site 2018 
Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus.   Baldwin, William S; Boswell, W Tyler; Ginjupalli, Gautam; Litoff, Elizabeth J R15ES017321 Nucl Receptor Res (2017) 28804711 Exiting the NIEHS site 2017 
Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-n ...   Kumar, Ramiya; Mota, Linda C; Litoff, Elizabeth J; Rooney, John P; Boswell, W Tyler; Courter, ... R15ES017321 PLoS One (2017) 28350814 Exiting the NIEHS site 2017 
Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin al ...   Sengupta, Namrata; Reardon, Delaney C; Gerard, Patrick D; Baldwin, William S R15ES017321 PLoS One (2017) 28542405 Exiting the NIEHS site 2017 
RNA sequencing indicates that atrazine induces multiple detoxification genes in Daphnia magna and th ...   Schmidt, Allison M; Sengupta, Namrata; Saski, Christopher A; Noorai, Rooksana E; Baldwin, Willi ... R15ES017321 Chemosphere (2017 Dec) 28968576 Exiting the NIEHS site 2017 
Perturbations in polar lipids, starvation survival and reproduction following exposure to unsaturate ...   Sengupta, Namrata; Gerard, Patrick D; Baldwin, William S R15ES017321 Chemosphere (2016 Feb) 26606184 Exiting the NIEHS site 2016 
Arachidonic acid enhances reproduction in Daphnia magna and mitigates changes in sex ratios induced ...   Ginjupalli, Gautam K; Gerard, Patrick D; Baldwin, William S R15ES017321 Environ Toxicol Chem (2015 Mar) 25393616 Exiting the NIEHS site 2015 
Repression of multiple CYP2D genes in mouse primary hepatocytes with a single siRNA construct.   Elraghy, Omaima; Baldwin, William S R15ES017321 In Vitro Cell Dev Biol Anim (2015 Jan) 25124873 Exiting the NIEHS site 2015 
The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA.   Sengupta, Namrata; Litoff, Elizabeth J; Baldwin, William S R15ES017321 Chemosphere (2015 Jun) 25747156 Exiting the NIEHS site 2015 
Annotation of the Daphnia magna nuclear receptors: comparison to Daphnia pulex.   Litoff, Elizabeth J; Garriott, Travis E; Ginjupalli, Gautam K; Butler, LaToya; Gay, Claudy; Sco ... R15ES017321 Gene (2014 Nov 15) 25239664 Exiting the NIEHS site 2014 
The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia s ...   Li, Yangchun; Ginjupalli, Gautam K; Baldwin, William S R15ES017321 Gen Comp Endocrinol (2014 Sep 15) 25092536 Exiting the NIEHS site 2014 
The time- and age-dependent effects of the juvenile hormone analog pesticide, pyriproxyfen on Daphni ...   Ginjupalli, Gautam K; Baldwin, William S R15ES017321 Chemosphere (2013 Aug) 23714148 Exiting the NIEHS site 2013 
Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptor.   Karimullina, Elina; Li, Yangchun; Ginjupalli, Gautam K; Baldwin, William S R15ES017321 Aquat Toxicol (2012 Jul 15) 22466357 Exiting the NIEHS site 2012 
Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.   Damiri, Basma; Holle, Eric; Yu, Xianzhong; Baldwin, William S R15ES017321 Toxicol Sci (2012 Feb) 22083726 Exiting the NIEHS site 2012 
Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes ...   Mota, Linda C; Barfield, Christina; Hernandez, Juan P; Baldwin, William S R15ES017321 Toxicol Appl Pharmacol (2011 May 1) 21376070 Exiting the NIEHS site 2011 
Selective imaging and killing of cancer cells with protein-activated near-infrared fluorescing nanop ...   Rungta, Parul; Bandera, Yuriy P; Roeder, Ryan D; Li, Yangchun; Baldwin, William S; Sharma, Dee ... R15ES017321 Macromol Biosci (2011 Jul 07) 21480531 Exiting the NIEHS site 2011 
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: associa ...   Mota, Linda C; Hernandez, Juan P; Baldwin, William S R15ES017321 Drug Metab Dispos (2010 Sep) 20573718 Exiting the NIEHS site 2010 
Dose-responsive gene expression changes in juvenile and adult mummichogs (Fundulus heteroclitus) aft ...   Gonzalez, Horacio O; Hu, Jianjun; Gaworecki, Kristen M; Roling, Jonathan A; Baldwin, William S; ... R15ES017321 Mar Environ Res (2010 Aug) 20451245 Exiting the NIEHS site 2010 
Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: ...   Van Aggelen, Graham; Ankley, Gerald T; Baldwin, William S; Bearden, Daniel W; Benson, William H ... R15ES017321 Environ Health Perspect (2010 Jan) 20056575 Exiting the NIEHS site 2010 
Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription ...   Hannas, Bethany R; Wang, Ying H; Baldwin, William S; Li, Yangchun; Wallace, Andrew D; LeBlanc, ... R15ES017321, T32ES007046 Gen Comp Endocrinol (2010 Jun 1) 20346363 Exiting the NIEHS site 2010 
A concentration addition model for the activation of the constitutive androstane receptor by xenobio ...   Baldwin, William S; Roling, Jonathan A R15ES017321 Toxicol Sci (2009 Jan) 18832183 Exiting the NIEHS site 2009 
Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolis ...   Hernandez, J P; Mota, L C; Baldwin, W S R15ES017321 Curr Pharmacogenomics Person Med (2009 Jun 01) 20871735 Exiting the NIEHS site 2009 
Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex.   Thomson, Susanne A; Baldwin, William S; Wang, Ying H; Kwon, Gwijun; Leblanc, Gerald A R15ES017321 BMC Genomics (2009 Oct 28) 19863811 Exiting the NIEHS site 2009 
Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).   Hernandez, J P; Mota, L C; Huang, W; Moore, D D; Baldwin, W S R15ES017321 Toxicology (2009 Feb 4) 19041682 Exiting the NIEHS site 2009 
The cytochrome P450 (CYP) gene superfamily in Daphnia pulex.   Baldwin, William S; Marko, Peter B; Nelson, David R R15ES017321 BMC Genomics (2009 Apr 21) 19383150 Exiting the NIEHS site 2009 
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