| Project Title: | FUNCTIONAL GENOMICS OF CHEMICAL-INDUCED ACUTE LUNG INJURY |
|---|---|
| PI: | Leikauf, George Douglas |
| Institution: | University Of Pittsburgh At Pittsburgh |
| Grant Number: | U01ES015675 |
These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Genetic determinants of ammonia-induced acute lung injury in mice. | Bein, Kiflai; Ganguly, Koustav; Martin, Timothy M; Concel, Vincent J; Brant, Kelly A; Di, Y P ... | U01ES015675 | Am J Physiol Lung Cell Mol Physiol (2021 01 01) |
33050709
|
2021 |
| Albumin Protects Lung Cells against Acrolein Cytotoxicity and Acrolein-Adducted Albumin Increases He ... | Bein, Kiflai; Birru, Rahel L; Wells, Heather; Larkin, Theodore P; Cantrell, Pamela S; Fagerburg ... | U01ES015675 | Chem Res Toxicol (2020 07 20) |
32530271
|
2020 |
| Augmented angiogenic transcription factor, SOX18, is associated with asthma exacerbation. | Hong, Jisu; Lee, Pureun-Haneul; Lee, Yun-Gi; Leikauf, George D; Jang, An-Soo | U01ES015675 | J Asthma (2020 May 27) |
32419535
|
2020 |
| Mechanisms of ultrafine particle-induced respiratory health effects. | Leikauf, George D; Kim, Sang-Heon; Jang, An-Soo | U01ES015675 | Exp Mol Med (2020 03) |
32203100
|
2020 |
| Proteomic identification of moesin upon exposure to acrolein. | Lee, Pureun-Haneul; Kim, Byeong-Gon; Lee, Sun-Hye; Leikauf, George D; Jang, An-Soo | U01ES015675 | Proteome Sci (2018) |
29375273
|
2018 |
| Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacki ... | Thimraj, Tania A; Birru, Rahel L; Mitra, Ankita; Schulz, Holger; Leikauf, George D; Ganguly, K ... | U01ES015675 | Lung (2017 04) |
28220305
|
2017 |
| Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel ... | George, Leema; Mitra, Ankita; Thimraj, Tania A; Irmler, Martin; Vishweswaraiah, Sangeetha; Lund ... | U01ES015675 | Respir Res (2017 08 09) |
28793908
|
2017 |
| Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice. | Latoche, Joseph D; Ufelle, Alexander Chukwuma; Fazzi, Fabrizio; Ganguly, Koustav; Leikauf, Geor ... | U01ES015675 | Environ Health Perspect (2016 08) |
26955063
|
2016 |
| Claudin 5 in a murine model of allergic asthma: Its implication and response to steroid treatment. | Moon, Kuk-Young; Lee, Pureun-Haneul; Kim, Byeong-Gon; Park, Choon-Sik; Leikauf, George D; Jang, ... | U01ES015675 | J Allergy Clin Immunol (2015 Dec) |
26409663
|
2015 |
| Diesel exhaust particle-induced airway responses are augmented in obese rats. | Moon, Kuk-Young; Park, Moo-Kyun; Leikauf, George D; Park, Choon-Sik; Jang, An-Soo | U01ES015675 | Int J Toxicol (2014 Jan-Feb) |
24536021
|
2014 |
| Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells. | Brant, Kelly A; Leikauf, George D | U01ES015675 | Mol Carcinog (2014 Mar) |
23065687
|
2014 |
| Novel PDE4 inhibitors derived from Chinese medicine forsythia. | Coon, Tiffany A; McKelvey, Alison C; Weathington, Nate M; Birru, Rahel L; Lear, Travis; Leikauf ... | U01ES015675 | PLoS One (2014) |
25549252
|
2014 |
| Secreted phosphoprotein 1 is a determinant of lung function development in mice. | Ganguly, Koustav; Martin, Timothy M; Concel, Vincent J; Upadhyay, Swapna; Bein, Kiflai; Brant, ... | U01ES015675 | Am J Respir Cell Mol Biol (2014 Nov) |
24816281
|
2014 |
| TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosi ... | Fazzi, Fabrizio; Njah, Joel; Di Giuseppe, Michelangelo; Winnica, Daniel E; Go, Kristina; Sala, ... | U01ES015675 | J Immunol (2014 Apr 15) |
24623132
|
2014 |
| Functional genomic assessment of phosgene-induced acute lung injury in mice. | Leikauf, George D; Concel, Vincent J; Bein, Kiflai; Liu, Pengyuan; Berndt, Annerose; Martin, T ... | U01ES015675 | Am J Respir Cell Mol Biol (2013 Sep) |
23590305
|
2013 |
| LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cells. | Bein, Kiflai; Di Giuseppe, Michelangelo; Mischler, Steven E; Ortiz, Luis A; Leikauf, George D | U01ES015675 | Am J Respir Cell Mol Biol (2013 Aug) |
23590297
|
2013 |
| Integrative assessment of chlorine-induced acute lung injury in mice. | Leikauf, George D; Pope-Varsalona, Hannah; Concel, Vincent J; Liu, Pengyuan; Bein, Kiflai; Bern ... | U01ES015675 | Am J Respir Cell Mol Biol (2012 Aug) |
22447970
|
2012 |
| WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. | Li, Hui-Hua; Li, Quan; Liu, Pengyuan; Liu, Yulin; Li, Jin; Wasserloos, Karla; Chao, Wei; You, ... | U01ES015675 | Am J Respir Cell Mol Biol (2012 Oct) |
22700866
|
2012 |
| Acrolein - a pulmonary hazard. | Bein, Kiflai; Leikauf, George D | U01ES015675 | Mol Nutr Food Res (2011 Sep) |
21994168
|
2011 |
| Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. | Lukinskiene, Lina; Liu, Yang; Reynolds, Susan D; Steele, Chad; Stripp, Barry R; Leikauf, Georg ... | U01ES015675 | J Immunol (2011 Jul 1) |
21632717
|
2011 |
| c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. | Lindsey, James Y; Ganguly, Koustav; Brass, David M; Li, Zhuowei; Potts, Erin N; Degan, Simone; ... | U01ES015675 | Am J Respir Crit Care Med (2011 06 15) |
21471107
|
2011 |
| Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury. | Jang, An Soo; Concel, Vincent J; Bein, Kiflai; Brant, Kelly A; Liu, Shannen; Pope-Varsalona, H ... | U01ES015675 | Am J Respir Cell Mol Biol (2011 Apr) |
20525806
|
2011 |
| Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1. | Leikauf, George D; Concel, Vincent J; Liu, Pengyuan; Bein, Kiflai; Berndt, Annerose; Ganguly, ... | U01ES015675 | Am J Respir Crit Care Med (2011 Jun 01) |
21297076
|
2011 |
| Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse ... | Fabisiak, James P; Medvedovic, Mario; Alexander, Danny C; McDunn, Jonathan E; Concel, Vincent J ... | U01ES015675 | Mol Nutr Food Res (2011 Sep) |
21823223
|
2011 |
| JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activi ... | Bein, Kiflai; Leight, Hayley; Leikauf, George D | U01ES015675 | Am J Respir Cell Mol Biol (2011 Aug) |
21148742
|
2011 |
| Functional genomics of chlorine-induced acute lung injury in mice. | Leikauf, George D; Pope-Varsalona, Hannah; Concel, Vincent J; Liu, Pengyuan; Bein, Kiflai; Bran ... | U01ES015675 | Proc Am Thorac Soc (2010 Jul) |
20601635
|
2010 |
| Genomewide association analysis of respiratory syncytial virus infection in mice. | Stark, James M; Barmada, M Michael; Winterberg, Abby V; Majumber, Nilanjana; Gibbons Jr, Willia ... | U01ES015675 | J Virol (2010 Mar) |
20015999
|
2010 |
| Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury. | Johansson, Elisabet; Wesselkamper, Scott C; Shertzer, Howard G; Leikauf, George D; Dalton, Timo ... | P30ES006096, U01ES015675 | Biochem Biophys Res Commun (2010 May 28) |
20417186
|
2010 |
| Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced l ... | Li, Huihua; Su, Xiaoli; Yan, Xuebin; Wasserloos, Karla; Chao, Wei; Kaynar, A Murat; Liu, Zhao ... | U01ES015675 | Anesthesiology (2010 Sep) |
20683250
|
2010 |
| LRpath: a logistic regression approach for identifying enriched biological groups in gene expression ... | Sartor, Maureen A; Leikauf, George D; Medvedovic, Mario | P30ES006096, U01ES015675 | Bioinformatics (2009 Jan 15) |
19038984
|
2009 |
| Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. | Deshmukh, Hitesh S; McLachlan, Anne; Atkinson, Jeffrey J; Hardie, William D; Korfhagen, Thomas ... | P30ES006096, U01ES015675 | Am J Respir Crit Care Med (2009 Nov 01) |
19661247
|
2009 |
| Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. | Nemec, Antonia A; Leikauf, George D; Pitt, Bruce R; Wasserloos, Karla J; Barchowsky, Aaron | U01ES015675 | Am J Respir Cell Mol Biol (2009 Jul) |
19097988
|
2009 |
| Specific fluorogenic probes for ozone in biological and atmospheric samples. | Garner, Amanda L; St Croix, Claudette M; Pitt, Bruce R; Leikauf, George D; Ando, Shin; Koide, ... | U01ES015675 | Nat Chem (2009 Jul) |
20634904
|
2009 |
| Superoxide dismutase 3, extracellular (SOD3) variants and lung function. | Ganguly, Koustav; Depner, Martin; Fattman, Cheryl; Bein, Kiflai; Oury, Tim D; Wesselkamper, Sc ... | U01ES015675 | Physiol Genomics (2009 May 13) |
19318538
|
2009 |
| Surfactant-associated protein B is critical to survival in nickel-induced injury in mice. | Bein, Kiflai; Wesselkamper, Scott C; Liu, Xiangdong; Dietsch, Maggie; Majumder, Nilanjana; Conc ... | P30ES006096, U01ES015675 | Am J Respir Cell Mol Biol (2009 Aug) |
19131640
|
2009 |
| Systemic inhibition of NF-kappaB activation protects from silicosis. | Di Giuseppe, Michelangelo; Gambelli, Federica; Hoyle, Gary W; Lungarella, Giuseppe; Studer, Sea ... | U01ES015675 | PLoS One (2009 May 25) |
19479048
|
2009 |
| The role of T cells in the regulation of acrolein-induced pulmonary inflammation and epithelial-cell ... | Borchers, Michael T; Wesselkamper, Scott C; Deshmukh, Hitesh; Beckman, Erin; Medvedovic, Mario; ... | U01ES015675 | Res Rep Health Eff Inst (2009 Dec) |
20218173
|
2009 |
| Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. | Knoell, Daren L; Julian, Mark W; Bao, Shengying; Besecker, Beth; Macre, Jennifer E; Leikauf, G ... | U01ES015675 | Crit Care Med (2009 Apr) |
19242332
|
2009 |
| Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. | Deshmukh, Hitesh S; Shaver, Colleen; Case, Lisa M; Dietsch, Maggie; Wesselkamper, Scott C; Hard ... | P30ES006096, U01ES015675 | Am J Respir Cell Mol Biol (2008 Apr) |
18006877
|
2008 |
| EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary ... | Hardie, William D; Davidson, Cynthia; Ikegami, Machiko; Leikauf, George D; Le Cras, Timothy D; ... | U01ES015675 | Am J Physiol Lung Cell Mol Physiol (2008 Jun) |
18424623
|
2008 |
| Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. | Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, ... | P30ES006096, U01ES015675 | Toxicol Sci (2008 Aug) |
18467339
|
2008 |
| Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time. | Prows, Daniel R; Hafertepen, Amanda P; Winterberg, Abby V; Gibbons Jr, William J; Wesselkamper, ... | P30ES006096, U01ES015675 | Am J Respir Cell Mol Biol (2008 Jan) |
17656683
|
2008 |
| Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein s ... | Ganguly, Koustav; Stoeger, Tobias; Wesselkamper, Scott C; Reinhard, Claudia; Sartor, Maureen A; ... | P30ES006096, U01ES015675 | Physiol Genomics (2007 Nov 14) |
17804602
|
2007 |
| CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irrit ... | Borchers, Michael T; Wesselkamper, Scott C; Harris, Nathaniel L; Deshmukh, Hitesh; Beckman, Eri ... | P30ES006096, T32ES007250, U01ES015675 | Exp Mol Pathol (2007 Dec) |
17950725
|
2007 |
| Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth f ... | Tichelaar, Jay W; Wesselkamper, Scott C; Chowdhury, Supurna; Yin, Hulian; Berclaz, Pierre-Yves; ... | U01ES015675 | Exp Lung Res (2007 Oct-Nov) |
17994369
|
2007 |
| Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. | Hardie, William D; Korfhagen, Thomas R; Sartor, Maureen A; Prestridge, Adrienne; Medvedovic, Ma ... | U01ES015675 | Am J Respir Cell Mol Biol (2007 Sep) |
17496152
|
2007 |
| Genomics and proteomics of lung disease: conference summary. | Raj, J Usha; Aliferis, Constantin; Caprioli, Richard M; Cowley Jr, Allen W; Davies, Peter F; Du ... | U01ES015675 | Am J Physiol Lung Cell Mol Physiol (2007 Jul) |
17468134
|
2007 |
| Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in mic ... | Sartor, Maureen A; Tomlinson, Craig R; Wesselkamper, Scott C; Sivaganesan, Siva; Leikauf, Georg ... | P30ES006096, U01ES015675 | BMC Bioinformatics (2006 Dec 19) |
17177995
|
2006 |
| The role of metallothionein in the pathogenesis of acute lung injury. | Wesselkamper, Scott C; McDowell, Susan A; Medvedovic, Mario; Dalton, Timothy P; Deshmukh, Hites ... | P30ES006096, T32ES007250, U01ES015675 | Am J Respir Cell Mol Biol (2006 Jan) |
16166738
|
2006 |
| Gene expression changes during the development of acute lung injury: role of transforming growth fac ... | Wesselkamper, Scott C; Case, Lisa M; Henning, Lisa N; Borchers, Michael T; Tichelaar, Jay W; Ma ... | P30ES006096, T32ES007250, U01ES015675 | Am J Respir Crit Care Med (2005 Dec 01) |
16100012
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2005 |
| Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. | Deshmukh, Hitesh S; Case, Lisa M; Wesselkamper, Scott C; Borchers, Michael T; Martin, Linda D; ... | P30ES006096, T32ES007250, U01ES015675 | Am J Respir Crit Care Med (2005 Feb 15) |
15531749
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2005 |
| When wheeze leads to squeeze: growth under pressure. | Leikauf, George D; Deshmukh, Hitesh S | U01ES015675 | Am J Respir Cell Mol Biol (2005 May) |
15837725
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2005 |