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Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: FUNCTIONAL GENOMICS OF CHEMICAL-INDUCED ACUTE LUNG INJURY
PI: Leikauf, George Douglas
Institution: University Of Pittsburgh At Pittsburgh
Grant Number: U01ES015675

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 52 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/U01ES015675/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Genetic determinants of ammonia-induced acute lung injury in mice.   Bein, Kiflai; Ganguly, Koustav; Martin, Timothy M; Concel, Vincent J; Brant, Kelly A; Di, Y P ... U01ES015675 Am J Physiol Lung Cell Mol Physiol (2021 01 01) 33050709 Exiting the NIEHS site 2021 
Albumin Protects Lung Cells against Acrolein Cytotoxicity and Acrolein-Adducted Albumin Increases He ...   Bein, Kiflai; Birru, Rahel L; Wells, Heather; Larkin, Theodore P; Cantrell, Pamela S; Fagerburg ... U01ES015675 Chem Res Toxicol (2020 07 20) 32530271 Exiting the NIEHS site 2020 
Augmented angiogenic transcription factor, SOX18, is associated with asthma exacerbation.   Hong, Jisu; Lee, Pureun-Haneul; Lee, Yun-Gi; Leikauf, George D; Jang, An-Soo U01ES015675 J Asthma (2020 May 27) 32419535 Exiting the NIEHS site 2020 
Mechanisms of ultrafine particle-induced respiratory health effects.   Leikauf, George D; Kim, Sang-Heon; Jang, An-Soo U01ES015675 Exp Mol Med (2020 03) 32203100 Exiting the NIEHS site 2020 
Proteomic identification of moesin upon exposure to acrolein.   Lee, Pureun-Haneul; Kim, Byeong-Gon; Lee, Sun-Hye; Leikauf, George D; Jang, An-Soo U01ES015675 Proteome Sci (2018) 29375273 Exiting the NIEHS site 2018 
Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacki ...   Thimraj, Tania A; Birru, Rahel L; Mitra, Ankita; Schulz, Holger; Leikauf, George D; Ganguly, K ... U01ES015675 Lung (2017 04) 28220305 Exiting the NIEHS site 2017 
Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel ...   George, Leema; Mitra, Ankita; Thimraj, Tania A; Irmler, Martin; Vishweswaraiah, Sangeetha; Lund ... U01ES015675 Respir Res (2017 08 09) 28793908 Exiting the NIEHS site 2017 
Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice.   Latoche, Joseph D; Ufelle, Alexander Chukwuma; Fazzi, Fabrizio; Ganguly, Koustav; Leikauf, Geor ... U01ES015675 Environ Health Perspect (2016 08) 26955063 Exiting the NIEHS site 2016 
Claudin 5 in a murine model of allergic asthma: Its implication and response to steroid treatment.   Moon, Kuk-Young; Lee, Pureun-Haneul; Kim, Byeong-Gon; Park, Choon-Sik; Leikauf, George D; Jang, ... U01ES015675 J Allergy Clin Immunol (2015 Dec) 26409663 Exiting the NIEHS site 2015 
Diesel exhaust particle-induced airway responses are augmented in obese rats.   Moon, Kuk-Young; Park, Moo-Kyun; Leikauf, George D; Park, Choon-Sik; Jang, An-Soo U01ES015675 Int J Toxicol (2014 Jan-Feb) 24536021 Exiting the NIEHS site 2014 
Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.   Brant, Kelly A; Leikauf, George D U01ES015675 Mol Carcinog (2014 Mar) 23065687 Exiting the NIEHS site 2014 
Novel PDE4 inhibitors derived from Chinese medicine forsythia.   Coon, Tiffany A; McKelvey, Alison C; Weathington, Nate M; Birru, Rahel L; Lear, Travis; Leikauf ... U01ES015675 PLoS One (2014) 25549252 Exiting the NIEHS site 2014 
Secreted phosphoprotein 1 is a determinant of lung function development in mice.   Ganguly, Koustav; Martin, Timothy M; Concel, Vincent J; Upadhyay, Swapna; Bein, Kiflai; Brant, ... U01ES015675 Am J Respir Cell Mol Biol (2014 Nov) 24816281 Exiting the NIEHS site 2014 
TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosi ...   Fazzi, Fabrizio; Njah, Joel; Di Giuseppe, Michelangelo; Winnica, Daniel E; Go, Kristina; Sala, ... U01ES015675 J Immunol (2014 Apr 15) 24623132 Exiting the NIEHS site 2014 
Functional genomic assessment of phosgene-induced acute lung injury in mice.   Leikauf, George D; Concel, Vincent J; Bein, Kiflai; Liu, Pengyuan; Berndt, Annerose; Martin, T ... U01ES015675 Am J Respir Cell Mol Biol (2013 Sep) 23590305 Exiting the NIEHS site 2013 
LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cells.   Bein, Kiflai; Di Giuseppe, Michelangelo; Mischler, Steven E; Ortiz, Luis A; Leikauf, George D U01ES015675 Am J Respir Cell Mol Biol (2013 Aug) 23590297 Exiting the NIEHS site 2013 
Integrative assessment of chlorine-induced acute lung injury in mice.   Leikauf, George D; Pope-Varsalona, Hannah; Concel, Vincent J; Liu, Pengyuan; Bein, Kiflai; Bern ... U01ES015675 Am J Respir Cell Mol Biol (2012 Aug) 22447970 Exiting the NIEHS site 2012 
WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury.   Li, Hui-Hua; Li, Quan; Liu, Pengyuan; Liu, Yulin; Li, Jin; Wasserloos, Karla; Chao, Wei; You, ... U01ES015675 Am J Respir Cell Mol Biol (2012 Oct) 22700866 Exiting the NIEHS site 2012 
Acrolein - a pulmonary hazard.   Bein, Kiflai; Leikauf, George D U01ES015675 Mol Nutr Food Res (2011 Sep) 21994168 Exiting the NIEHS site 2011 
Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection.   Lukinskiene, Lina; Liu, Yang; Reynolds, Susan D; Steele, Chad; Stripp, Barry R; Leikauf, Georg ... U01ES015675 J Immunol (2011 Jul 1) 21632717 Exiting the NIEHS site 2011 
c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.   Lindsey, James Y; Ganguly, Koustav; Brass, David M; Li, Zhuowei; Potts, Erin N; Degan, Simone; ... U01ES015675 Am J Respir Crit Care Med (2011 06 15) 21471107 Exiting the NIEHS site 2011 
Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury.   Jang, An Soo; Concel, Vincent J; Bein, Kiflai; Brant, Kelly A; Liu, Shannen; Pope-Varsalona, H ... U01ES015675 Am J Respir Cell Mol Biol (2011 Apr) 20525806 Exiting the NIEHS site 2011 
Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.   Leikauf, George D; Concel, Vincent J; Liu, Pengyuan; Bein, Kiflai; Berndt, Annerose; Ganguly, ... U01ES015675 Am J Respir Crit Care Med (2011 Jun 01) 21297076 Exiting the NIEHS site 2011 
Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse ...   Fabisiak, James P; Medvedovic, Mario; Alexander, Danny C; McDunn, Jonathan E; Concel, Vincent J ... U01ES015675 Mol Nutr Food Res (2011 Sep) 21823223 Exiting the NIEHS site 2011 
JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activi ...   Bein, Kiflai; Leight, Hayley; Leikauf, George D U01ES015675 Am J Respir Cell Mol Biol (2011 Aug) 21148742 Exiting the NIEHS site 2011 
Functional genomics of chlorine-induced acute lung injury in mice.   Leikauf, George D; Pope-Varsalona, Hannah; Concel, Vincent J; Liu, Pengyuan; Bein, Kiflai; Bran ... U01ES015675 Proc Am Thorac Soc (2010 Jul) 20601635 Exiting the NIEHS site 2010 
Genomewide association analysis of respiratory syncytial virus infection in mice.   Stark, James M; Barmada, M Michael; Winterberg, Abby V; Majumber, Nilanjana; Gibbons Jr, Willia ... U01ES015675 J Virol (2010 Mar) 20015999 Exiting the NIEHS site 2010 
Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury.   Johansson, Elisabet; Wesselkamper, Scott C; Shertzer, Howard G; Leikauf, George D; Dalton, Timo ... P30ES006096, U01ES015675 Biochem Biophys Res Commun (2010 May 28) 20417186 Exiting the NIEHS site 2010 
Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced l ...   Li, Huihua; Su, Xiaoli; Yan, Xuebin; Wasserloos, Karla; Chao, Wei; Kaynar, A Murat; Liu, Zhao ... U01ES015675 Anesthesiology (2010 Sep) 20683250 Exiting the NIEHS site 2010 
LRpath: a logistic regression approach for identifying enriched biological groups in gene expression ...   Sartor, Maureen A; Leikauf, George D; Medvedovic, Mario P30ES006096, U01ES015675 Bioinformatics (2009 Jan 15) 19038984 Exiting the NIEHS site 2009 
Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.   Deshmukh, Hitesh S; McLachlan, Anne; Atkinson, Jeffrey J; Hardie, William D; Korfhagen, Thomas ... P30ES006096, U01ES015675 Am J Respir Crit Care Med (2009 Nov 01) 19661247 Exiting the NIEHS site 2009 
Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.   Nemec, Antonia A; Leikauf, George D; Pitt, Bruce R; Wasserloos, Karla J; Barchowsky, Aaron U01ES015675 Am J Respir Cell Mol Biol (2009 Jul) 19097988 Exiting the NIEHS site 2009 
Specific fluorogenic probes for ozone in biological and atmospheric samples.   Garner, Amanda L; St Croix, Claudette M; Pitt, Bruce R; Leikauf, George D; Ando, Shin; Koide, ... U01ES015675 Nat Chem (2009 Jul) 20634904 Exiting the NIEHS site 2009 
Superoxide dismutase 3, extracellular (SOD3) variants and lung function.   Ganguly, Koustav; Depner, Martin; Fattman, Cheryl; Bein, Kiflai; Oury, Tim D; Wesselkamper, Sc ... U01ES015675 Physiol Genomics (2009 May 13) 19318538 Exiting the NIEHS site 2009 
Surfactant-associated protein B is critical to survival in nickel-induced injury in mice.   Bein, Kiflai; Wesselkamper, Scott C; Liu, Xiangdong; Dietsch, Maggie; Majumder, Nilanjana; Conc ... P30ES006096, U01ES015675 Am J Respir Cell Mol Biol (2009 Aug) 19131640 Exiting the NIEHS site 2009 
Systemic inhibition of NF-kappaB activation protects from silicosis.   Di Giuseppe, Michelangelo; Gambelli, Federica; Hoyle, Gary W; Lungarella, Giuseppe; Studer, Sea ... U01ES015675 PLoS One (2009 May 25) 19479048 Exiting the NIEHS site 2009 
The role of T cells in the regulation of acrolein-induced pulmonary inflammation and epithelial-cell ...   Borchers, Michael T; Wesselkamper, Scott C; Deshmukh, Hitesh; Beckman, Erin; Medvedovic, Mario; ... U01ES015675 Res Rep Health Eff Inst (2009 Dec) 20218173 Exiting the NIEHS site 2009 
Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis.   Knoell, Daren L; Julian, Mark W; Bao, Shengying; Besecker, Beth; Macre, Jennifer E; Leikauf, G ... U01ES015675 Crit Care Med (2009 Apr) 19242332 Exiting the NIEHS site 2009 
Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.   Deshmukh, Hitesh S; Shaver, Colleen; Case, Lisa M; Dietsch, Maggie; Wesselkamper, Scott C; Hard ... P30ES006096, U01ES015675 Am J Respir Cell Mol Biol (2008 Apr) 18006877 Exiting the NIEHS site 2008 
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary ...   Hardie, William D; Davidson, Cynthia; Ikegami, Machiko; Leikauf, George D; Le Cras, Timothy D; ... U01ES015675 Am J Physiol Lung Cell Mol Physiol (2008 Jun) 18424623 Exiting the NIEHS site 2008 
Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury.   Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, ... P30ES006096, U01ES015675 Toxicol Sci (2008 Aug) 18467339 Exiting the NIEHS site 2008 
Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time.   Prows, Daniel R; Hafertepen, Amanda P; Winterberg, Abby V; Gibbons Jr, William J; Wesselkamper, ... P30ES006096, U01ES015675 Am J Respir Cell Mol Biol (2008 Jan) 17656683 Exiting the NIEHS site 2008 
Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein s ...   Ganguly, Koustav; Stoeger, Tobias; Wesselkamper, Scott C; Reinhard, Claudia; Sartor, Maureen A; ... P30ES006096, U01ES015675 Physiol Genomics (2007 Nov 14) 17804602 Exiting the NIEHS site 2007 
CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irrit ...   Borchers, Michael T; Wesselkamper, Scott C; Harris, Nathaniel L; Deshmukh, Hitesh; Beckman, Eri ... P30ES006096, T32ES007250, U01ES015675 Exp Mol Pathol (2007 Dec) 17950725 Exiting the NIEHS site 2007 
Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth f ...   Tichelaar, Jay W; Wesselkamper, Scott C; Chowdhury, Supurna; Yin, Hulian; Berclaz, Pierre-Yves; ... U01ES015675 Exp Lung Res (2007 Oct-Nov) 17994369 Exiting the NIEHS site 2007 
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.   Hardie, William D; Korfhagen, Thomas R; Sartor, Maureen A; Prestridge, Adrienne; Medvedovic, Ma ... U01ES015675 Am J Respir Cell Mol Biol (2007 Sep) 17496152 Exiting the NIEHS site 2007 
Genomics and proteomics of lung disease: conference summary.   Raj, J Usha; Aliferis, Constantin; Caprioli, Richard M; Cowley Jr, Allen W; Davies, Peter F; Du ... U01ES015675 Am J Physiol Lung Cell Mol Physiol (2007 Jul) 17468134 Exiting the NIEHS site 2007 
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in mic ...   Sartor, Maureen A; Tomlinson, Craig R; Wesselkamper, Scott C; Sivaganesan, Siva; Leikauf, Georg ... P30ES006096, U01ES015675 BMC Bioinformatics (2006 Dec 19) 17177995 Exiting the NIEHS site 2006 
The role of metallothionein in the pathogenesis of acute lung injury.   Wesselkamper, Scott C; McDowell, Susan A; Medvedovic, Mario; Dalton, Timothy P; Deshmukh, Hites ... P30ES006096, T32ES007250, U01ES015675 Am J Respir Cell Mol Biol (2006 Jan) 16166738 Exiting the NIEHS site 2006 
Gene expression changes during the development of acute lung injury: role of transforming growth fac ...   Wesselkamper, Scott C; Case, Lisa M; Henning, Lisa N; Borchers, Michael T; Tichelaar, Jay W; Ma ... P30ES006096, T32ES007250, U01ES015675 Am J Respir Crit Care Med (2005 Dec 01) 16100012 Exiting the NIEHS site 2005 
Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.   Deshmukh, Hitesh S; Case, Lisa M; Wesselkamper, Scott C; Borchers, Michael T; Martin, Linda D; ... P30ES006096, T32ES007250, U01ES015675 Am J Respir Crit Care Med (2005 Feb 15) 15531749 Exiting the NIEHS site 2005 
When wheeze leads to squeeze: growth under pressure.   Leikauf, George D; Deshmukh, Hitesh S U01ES015675 Am J Respir Cell Mol Biol (2005 May) 15837725 Exiting the NIEHS site 2005 
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