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National Institute of Environmental Health Sciences

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Publication Detail

Title: Human placental lipid peroxidation--II. NADPH and iron dependent stimulation of microsomal lipid peroxidation by paraquat.

Authors: Kenel, M F; Bestervelt, L L; Kulkarni, A P

Published In Gen Pharmacol, (1987)

Abstract: Paraquat, a widely used herbicide, was found to cause a marked stimulation of lipid peroxidation in the human placental microsomes in vitro. Both NADPH and chelated iron were necessary to observe paraquat-stimulated lipid peroxidation. The malondialdehyde accumulation in the incubation medium increased with increase in time, protein and paraquat concentration. The reaction did not exhibit the initial lag phase suggesting that endogenous membrane-bound antioxidants in human placental microsomes are either absent or present in extremely small quantities.

PubMed ID: 3038664 Exiting the NIEHS site

MeSH Terms: Humans; In Vitro Techniques; Iron/pharmacology*; Lipid Peroxides/metabolism*; Microsomes/metabolism; NADP/pharmacology*; Paraquat/pharmacology*; Placenta/metabolism*; Superoxides/metabolism

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