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Publication Detail

Title: Effects of cyclosporin A on a kidney epithelial cell line (LLC-PK1).

Authors: Becker, G M; Gandolfi, A J; Nagle, R B

Published In Res Commun Chem Pathol Pharmacol, (1987 May)

Abstract: Cyclosporin A (CSA), a potent immunosuppressant with the adverse side effect of nephrotoxicity, inhibited cell growth of pig kidney tubule cells (LLC-PK1) in culture. CSA (10(-5) M) also induced intense cytoplasmic vacuolation and the formation of dense granules. At the same concentration an analogue of CSA, cyclosporin G, had much less effect. This cell line may prove useful for revealing the mechanism of CSA-nephrotoxicity and testing the nephrotoxic potential of new analogues of cyclosporine.

PubMed ID: 3602589 Exiting the NIEHS site

MeSH Terms: Animals; Cell Division/drug effects; Cell Line; Cyclosporine*; Cyclosporins/pharmacology*; Kidney/drug effects*; Swine

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