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Publication Detail

Title: Oxidation of thiol drugs and biochemicals by the lactoperoxidase/hydrogen peroxide system.

Authors: Mottley, C; Toy, K; Mason, R P

Published In Mol Pharmacol, (1987 Apr)

Abstract: The thiol moiety is prone to oxidative free radical formation, which may be important in mediating the toxicity of some thiol-containing compounds. The oxidation of the compounds cysteine, cysteamine, N-acetylcysteine, glutathione, penicillamine, and captopril were studied using ESR and oxygen uptake techniques. Lactoperoxidase, with hydrogen peroxide to provide oxidizing equivalents, was used to initiate the oxidation. The reaction appears to be strongly peroxide dependent, with either exogenous H2O2 or thiol-derived peroxide driving the reaction.

PubMed ID: 3033467 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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