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Publication Detail

Title: Enzymatic denitrification of 2-nitropropane in uninduced mouse liver microsomes.

Authors: Marker, E K; Kulkarni, A P

Published In Toxicol Lett, (1985 Aug)

Abstract: Hepatic microsomes from 5 strains of untreated mice were tested for the ability to enzymatically cleave the nitro group from 2-nitropropane (2NP). All strains showed significant NADPH-dependent nitrite release at pH 7.6 and pH 8.8. Statistical differences in nitrite-releasing activity between strains were found between BALB and PL/J and ATH strains at pH 7.6. At pH 8.8, BIO.M differed from CD-1 and BALB. These results are in contrast to a report of little or no denitrification activity in uninduced rats and suggest that the 2NP microsomal metabolism may be of greater importance than previously thought.

PubMed ID: 4035711 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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