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National Institute of Environmental Health Sciences

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Publication Detail

Title: Carbon tetrachloride depresses hepatic phospholipid synthesis in rats.

Authors: Gebhart, A M; Brabec, M J

Published In Toxicol Lett, (1985 Jan)

Abstract: 40 h after an acute dose of CCl4 (11.3 mmol/kg), the incorporation of [1-3H]ethanolamine into rat hepatic microsomal phospholipids was inhibited to 70% of control. Incorporation into phospholipids of the inner and outer mitochondrial membranes was 30-35% of control. Rates of incorporation were equal to or above normal rates in all membranes 65 h after dosage. The activity of methyltransferase in microsomal fractions isolated from rats 10 to 66 h after dosage was depressed. These data suggest that the alteration of mitochondrial phospholipids that parallels mitochondrial dysfunction after acute CCl4 dosage could be attributed to a CCl4-induced inhibition of the microsomal phospholipid biosynthetic pathways.

PubMed ID: 3975932 Exiting the NIEHS site

MeSH Terms: Animals; Carbon Tetrachloride Poisoning/metabolism*; Ethanolamine; Ethanolamines/metabolism; Liver/drug effects*; Liver/metabolism; Male; Methyltransferases/metabolism; Oxidative Phosphorylation/drug effects; Phosphatidyl-N-Methylethanolamine N-Methyltransferase; Phosphatidylcholines/metabolism; Phosphatidylethanolamines/metabolism; Phospholipids/biosynthesis*; Rats; Rats, Inbred Strains

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