Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Pharmacokinetics of digoxin in sheep: limitations of the use of biological half-life for interspecies extrapolation.

Authors: Dix, L P; Bai, S A; Rogers, R A; Anderson, D L; Riviere, J E

Published In Am J Vet Res, (1985 Feb)

Abstract: After of single IV digoxin injection of 50 micrograms/kg of body weight, the serum digoxin concentrations of 4 sheep were fitted to a 2-compartment open model. The mean value for the elimination half-life was 7.15 hours; for area volume of distribution, 13.8 L/kg; and for total body clearance, 1.36 L/kg/hr. A comparison of this study with previous studies in sheep and cattle revealed that serious misconceptions could arise if one chose to rely upon elimination half-life as the sole descriptor of drug disposition. A more informative characterization was determined to be total body clearance and area volume of distribution.

PubMed ID: 3994115 Exiting the NIEHS site

MeSH Terms: Animals; Digoxin/administration & dosage; Digoxin/blood; Digoxin/metabolism*; Half-Life; Injections, Intravenous/veterinary; Kinetics; Sheep/metabolism*; Species Specificity

Back
to Top