Title: Alcohol consumption and risk of adult-onset acute myeloid leukemia: results from a Los Angeles County case-control study.
Authors: Pogoda, Janice M; Nichols, Peter W; Preston-Martin, Susan
Published In Leuk Res, (2004 Sep)
Abstract: Few studies have examined the role of alcohol consumption in risk of adult acute myeloid leukemia (AML). Two previous case-control studies resulted in inconsistent findings. We report data from a Los Angeles County population-based case-control study in which 164 matched case-control pairs were asked about lifetime history of alcohol consumption and 136 cases were subtyped according to the French-American-British (FAB) criteria. Estimated categorical odds ratios (OR) adjusted for smoking and education were suggestive of a possible protective effect but trend tests were non-significant. Analyses by FAB subtype did not reveal subtype-specific associations but generally suffered from lack of power. Larger studies are needed to more thoroughly investigate the relationship between alcohol consumption and AML risk.
PubMed ID: 15234569
MeSH Terms: Acute Disease; Adult; Age of Onset; Aged; Alcohol Drinking/adverse effects*; Case-Control Studies; Female; Humans; Leukemia, Myeloid/etiology*; Los Angeles/epidemiology; Male; Middle Aged; Odds Ratio; Protective Agents/pharmacology; Risk Factors