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Title: Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines.

Authors: Park, Eun-Kee; Mak, Sally K; Kultz, Dietmar; Hammock, Bruce D

Published In J Environ Sci Health B, (2008 Jan)

Abstract: The present study investigates renal inner medullary collecting duct (mIMCD3) cells and human embryonic kidney cells (HEK293) for evaluation of cytotoxicity of nephrotoxic compounds. The 24 h LC(50) values for cisplatin, paraquat and ibuprofen in mIMCD3 cells were 135, 155 and 3600 microM, respectively. The 24 h LC(50) values for paraquat and ibuprofen in HEK293 cells were 180 and 1000 microM, respectively. Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat.

PubMed ID: 18161576 Exiting the NIEHS site

MeSH Terms: Animals; Cell Line; Cell Survival/drug effects*; Cisplatin/toxicity*; Dose-Response Relationship, Drug; Humans; Ibuprofen/toxicity*; Kidney Medulla/cytology; Kidney Medulla/drug effects; Kidney Tubules, Collecting/cytology; Kidney Tubules, Collecting/drug effects; Kidney/cytology*; Kidney/drug effects*; Lethal Dose 50; Mice; Osmolar Concentration; Paraquat/toxicity*

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