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Publication Detail

Title: Statin use and the risk of Parkinson disease.

Authors: Wahner, Angelika D; Bronstein, Jeff M; Bordelon, Yvette M; Ritz, Beate

Published In Neurology, (2008 Apr 15)

Abstract: To investigate associations between statin (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor) use and Parkinson disease (PD).We used a population-based design to recruit 312 incident idiopathic PD cases and 342 controls from three rural California counties.We observed a higher frequency of statin use among controls vs cases (OR 0.45; 95% CI 0.29 to 0.71) and a strong dose-response relation. The strongest protective association between statin use and PD was observed in long-term (>or=5 years) users (OR 0.37; 95% CI 0.18 to 0.78). There was no difference by gender or age. We noted 60 to 70% risk reductions for each individual statin except pravastatin.Ascribing causality to these associations is premature and further studies are needed to confirm a potential neuroprotective role for statins in PD.

PubMed ID: 18184918 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects*; Male; Middle Aged; Parkinson Disease, Secondary/chemically induced*; Parkinson Disease, Secondary/epidemiology*; Risk Factors

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