Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Mechanism of arsenic carcinogenesis: an integrated approach.

Authors: Rossman, Toby G

Published In Mutat Res, (2003 Dec 10)

Abstract: Epidemiological evidence shows an association between inorganic arsenic in drinking water and increased risk of skin, lung and bladder cancers. The lack of animal models has hindered mechanistic studies of arsenic carcinogenesis in the past, but some promising new models for these cancers are now available. The various forms of arsenic to which humans are exposed, either directly or via metabolism of inorganic arsenic to various methylated forms, further complicate the issue of mechanism, since these compounds can have different effects, both genotoxic and non-genotoxic. This review will try to integrate all of these issues, with a strong bias toward effects that are produced by environmentally relevant arsenic concentrations.

PubMed ID: 14643412 Exiting the NIEHS site

MeSH Terms: Animals; Arsenic/toxicity*; Arsenites/toxicity; Carcinogens/toxicity*; Cell Division; Chromosomal Instability; DNA Damage; DNA Methylation; Environmental Exposure; Gene Amplification; Humans; Mice; Models, Animal; Neoplasms/chemically induced*

Back
to Top