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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: ATR: an essential regulator of genome integrity.

Authors: Cimprich, Karlene A; Cortez, David

Published In Nat Rev Mol Cell Biol, (2008 Aug)

Abstract: Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.

PubMed ID: 18594563 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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