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Publication Detail

Title: Altered vesicular dopamine storage in Parkinson's disease: a premature demise.

Authors: Caudle, W Michael; Colebrooke, Rebecca E; Emson, Piers C; Miller, Gary W

Published In Trends Neurosci, (2008 Jun)

Abstract: Dopamine is a potentially toxic neurotransmitter that has long been speculated to contribute to the pathogenesis of Parkinson's disease (PD). Recent work has demonstrated the importance of proper storage of dopamine in vesicles to maintain dopamine homeostasis, thus protecting neurons from the detrimental effects of dopamine accumulation and breakdown in the cytosol. These studies suggest that factors which affect dopamine storage might increase the susceptibility of dopamine neurons to further environmental or genetic insults, exacerbating the neuronal degeneration that characterizes PD. This review seeks to revisit the pathogenicity of cytosolic dopamine and further address the critical role of neurotransmitter storage in dopamine-mediated neurotoxicity.

PubMed ID: 18471904 Exiting the NIEHS site

MeSH Terms: Animals; Dopamine/metabolism*; Humans; Neurons/metabolism; Parkinson Disease/genetics; Parkinson Disease/metabolism*; Parkinson Disease/pathology*; Synucleins/metabolism; Vesicular Monoamine Transport Proteins/genetics

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