Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Mixture cure model with an application to interval mapping of quantitative trait loci.

Authors: Liu, Mengling; Lu, Wenbin; Shao, Yongzhao

Published In Lifetime Data Anal, (2006 Dec)

Abstract: When censored time-to-event data are used to map quantitative trait loci (QTL), the existence of nonsusceptible subjects entails extra challenges. If the heterogeneous susceptibility is ignored or inappropriately handled, we may either fail to detect the responsible genetic factors or find spuriously significant locations. In this article, an interval mapping method based on parametric mixture cure models is proposed, which takes into consideration of nonsusceptible subjects. The proposed model can be used to detect the QTL that are responsible for differential susceptibility and/or time-to-event trait distribution. In particular, we propose a likelihood-based testing procedure with genome-wide significance levels calculated using a resampling method. The performance of the proposed method and the importance of considering the heterogeneous susceptibility are demonstrated by simulation studies and an application to survival data from an experiment on mice infected with Listeria monocytogenes.

PubMed ID: 17063400 Exiting the NIEHS site

MeSH Terms: Algorithms; Animals; Biometry; Listeriosis/genetics; Mice; Models, Genetic; Models, Statistical*; Proportional Hazards Models; Quantitative Trait Loci*; Time Factors

Back
to Top