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Publication Detail

Title: NF-kappaB and cancer-identifying targets and mechanisms.

Authors: Naugler, Willscott E; Karin, Michael

Published In Curr Opin Genet Dev, (2008 Feb)

Abstract: A connection between inflammation and carcinogenesis has long been known, but the precise mechanisms are just beginning to be understood. NF-kappaB proteins, transcription factors which integrate stress signals and orchestrate immune responses, have also recently been linked to carcinogenesis. Hallmarks of cancer development include self-sufficiency in growth signals, insensitivity to growth-inhibitors, evasion of apoptosis, limitless replicative potential, tissue invasion and metastasis, and sustained angiogenesis. NF-kappaB signaling has been implicated in each of these hallmarks, and recent experimental studies have illuminated the mechanistic pathways by which NF-kappaB signaling contributes to these aspects of carcinogenesis. This review will focus on recent experimental data supporting the hypothesis that inflammation promotes carcinogenesis, and that NF-kappaB signaling is at the heart of such inflammation.

PubMed ID: 18440219 Exiting the NIEHS site

MeSH Terms: Apoptosis; Cell Proliferation; Humans; Inflammation/complications*; NF-kappa B/metabolism*; Neoplasm Metastasis; Neoplasms/blood supply; Neoplasms/immunology*; Neoplasms/pathology; Neovascularization, Pathologic; Signal Transduction

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